FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308784725> ?p ?o ?g. }

• W4308784725 endingPage "8999" @default.
• W4308784725 startingPage "8982" @default.
• W4308784725 abstract "Chlorpyrifos (CPF) is a class of toxic compounds which has been widely used in agriculture that can cause multi-organ damage to the liver, kidneys, testes, and nervous system. Currently, most studies on ginseng have concentrated on the roots and rhizomes, and less research has been conducted on the above-ground parts. Our laboratory found that ginseng stem and leaf total saponin (GSLS) features strong antioxidant activity. In this experiment, we selected different concentrations of CPF to induce hippocampal neuronal cell injury model in mice, conducted a cell survival screening test, and also selected appropriate concentrations of CPF to induce brain injury model in mice. CCK-8, flow cytometry, Elisa, Hoechst 33258 staining, Annexin V-FITC/PI staining, HE staining, Morris water maze, and qRT-PCR were adopted for detecting the effects of GSLS treatment on CPF-induced cell viability, mitochondrial membrane potential, reactive oxygen species (ROS) levels, Ca2+ concentration and GSLS treatment on CPF-induced brain injury and related signaling in mice, respectively. The effects of GSLS treatment on CPF-induced brain injury and the related signaling pathways in mice were examined. The results showed that GSLS at 60 μg/ml and 125 μg/ml concentrations elevated the viability of CPF-induced HT22 cells, increased mitochondrial membrane potential, depleted ROS, decreased Ca2+ concentration, and decreased apoptosis rate. Meanwhile, GSLS treatment significantly reduced CPF-induced escape latency in mice, elevated the number of entries into the plateau and effective area, increased the effective area and target quadrant residence time, as well as improved the pathological damage of mouse hippocampal neurons. The results of mouse brain sections demonstrated that GSLS treatment significantly increased SOD and CAT activities and lowered MDA accumulation in CPF-induced mice. qRT-PCR revealed that PTEN mRNA expression was significantly decreased with PI3K and AKT expression being significantly increased in GSLS-treated CPF-induced mice. Thus, the obtained results indicate that GSLS can effectively antagonize CPF-induced brain toxicity in mice through regulating PTEN/PI3K/AKT pathway." @default.
• W4308784725 created "2022-11-15" @default.
• W4308784725 creator A5003741499 @default.
• W4308784725 creator A5015650704 @default.
• W4308784725 creator A5021864206 @default.
• W4308784725 creator A5028470766 @default.
• W4308784725 creator A5043165027 @default.
• W4308784725 creator A5054159069 @default.
• W4308784725 creator A5058065573 @default.
• W4308784725 creator A5088352404 @default.
• W4308784725 date "2022-11-11" @default.
• W4308784725 modified "2023-10-16" @default.
• W4308784725 title "Protective effect of total saponins of ginseng stems and leaves (GSLS) on chlorpyrifos-induced brain toxicity in mice through the PTEN/PI3K/AKT axis" @default.
• W4308784725 cites W1983603356 @default.
• W4308784725 cites W1995199032 @default.
• W4308784725 cites W1997811174 @default.
• W4308784725 cites W2064055988 @default.
• W4308784725 cites W2094822406 @default.
• W4308784725 cites W2104964105 @default.
• W4308784725 cites W2106391853 @default.
• W4308784725 cites W2146561348 @default.
• W4308784725 cites W2225994292 @default.
• W4308784725 cites W2314697488 @default.
• W4308784725 cites W2326000730 @default.
• W4308784725 cites W2529461396 @default.
• W4308784725 cites W2531645633 @default.
• W4308784725 cites W2536024417 @default.
• W4308784725 cites W2538132594 @default.
• W4308784725 cites W2592309743 @default.
• W4308784725 cites W2594785621 @default.
• W4308784725 cites W2597855987 @default.
• W4308784725 cites W2598750890 @default.
• W4308784725 cites W2614078888 @default.
• W4308784725 cites W2618149557 @default.
• W4308784725 cites W2739182934 @default.
• W4308784725 cites W2772222521 @default.
• W4308784725 cites W2772490526 @default.
• W4308784725 cites W2792156679 @default.
• W4308784725 cites W2806057690 @default.
• W4308784725 cites W2889112219 @default.
• W4308784725 cites W2889216363 @default.
• W4308784725 cites W2897537084 @default.
• W4308784725 cites W2902047046 @default.
• W4308784725 cites W2907054137 @default.
• W4308784725 cites W2914942253 @default.
• W4308784725 cites W2945142626 @default.
• W4308784725 cites W2947235104 @default.
• W4308784725 cites W2967187771 @default.
• W4308784725 cites W2969906035 @default.
• W4308784725 cites W2980706715 @default.
• W4308784725 cites W2981175799 @default.
• W4308784725 cites W2992462611 @default.
• W4308784725 cites W2998367294 @default.
• W4308784725 cites W3002242413 @default.
• W4308784725 cites W3003266517 @default.
• W4308784725 cites W3004203437 @default.
• W4308784725 cites W3008880576 @default.
• W4308784725 cites W3009576699 @default.
• W4308784725 cites W3009970038 @default.
• W4308784725 cites W3013680583 @default.
• W4308784725 cites W3025390068 @default.
• W4308784725 cites W3028013240 @default.
• W4308784725 cites W3037134588 @default.
• W4308784725 cites W3038635871 @default.
• W4308784725 cites W3039890569 @default.
• W4308784725 cites W3040744564 @default.
• W4308784725 cites W3042189474 @default.
• W4308784725 cites W3081208786 @default.
• W4308784725 cites W3091154589 @default.
• W4308784725 cites W3119827826 @default.
• W4308784725 cites W3137007204 @default.
• W4308784725 cites W3137639332 @default.
• W4308784725 cites W3146013771 @default.
• W4308784725 cites W3156847384 @default.
• W4308784725 cites W3159247516 @default.
• W4308784725 cites W3164725515 @default.
• W4308784725 cites W3183270819 @default.
• W4308784725 cites W3183334165 @default.
• W4308784725 cites W3197450235 @default.
• W4308784725 cites W3199349419 @default.
• W4308784725 cites W3208942529 @default.
• W4308784725 doi "https://doi.org/10.18632/aging.204374" @default.
• W4308784725 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36374217" @default.
• W4308784725 hasPublicationYear "2022" @default.
• W4308784725 type Work @default.
• W4308784725 citedByCount "0" @default.
• W4308784725 crossrefType "journal-article" @default.
• W4308784725 hasAuthorship W4308784725A5003741499 @default.
• W4308784725 hasAuthorship W4308784725A5015650704 @default.
• W4308784725 hasAuthorship W4308784725A5021864206 @default.
• W4308784725 hasAuthorship W4308784725A5028470766 @default.
• W4308784725 hasAuthorship W4308784725A5043165027 @default.
• W4308784725 hasAuthorship W4308784725A5054159069 @default.
• W4308784725 hasAuthorship W4308784725A5058065573 @default.
• W4308784725 hasAuthorship W4308784725A5088352404 @default.
• W4308784725 hasBestOaLocation W43087847251 @default.
• W4308784725 hasConcept C142724271 @default.
• W4308784725 hasConcept C178790620 @default.

• next