FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308785103> ?p ?o ?g. }

• W4308785103 endingPage "66" @default.
• W4308785103 startingPage "61" @default.
• W4308785103 abstract "Improving the prevention and treatment of epilepsy is one of the urgent tasks. Based on the available data on the anticonvulsant activity of the cardiac glycoside digoxin, it is advisable to compare the anticonvulsant effect of the drug by different routes of administration in the experiment. Aim. To determine the impact of the route of administration on the anticonvulsant effect of the cardiac glycoside digoxin on basic models of primary generalized seizures induced by pentylenetetrazol and maximal electric shock. Materials and methods. Two basic models were used: the model of primary generalized convulsions induced in mice by pentylenetetrazol (80 mg/kg subcutaneously) and maximal electric shock (current strength – 50 mA, frequency – 50 Hz, 0.2 sec corneally). Digoxin was administered in the dose of 0.8 mg/kg (about 1/10 LD50) 30 min before modeling seizures in the stomach and subcutaneously. Standard parameters of convulsive syndrome severity and mortality were recorded. Results and discussion. In both seizure models, the anticonvulsant effect of digoxin was little dependent on the route of administration. In the pentylenetetrazole-induced model, with both routes of administration, lethality tended to decrease; when administered intragastrically, digoxin statistically significantly reduced the number of clonic-tonic seizures per 1 mouse, the number of animals with the most severe tonic seizures, and the duration of the convulsive period; when administered subcutaneously, it significantly increased the latent period of seizures and reduced the number of animals with tonic seizures. In the model of maximal electric shock, digoxin reduced seizure severity andlethality almost equally by both routes of administration (by 55 % with the intragastric administration and by 67.5 % with the subcutaneous administration). In both models, there were no statistically significant differences in the course of seizures in both routes of the digoxin administration. With subcutaneous administration, the anticonvulsant effect was somewhat more pronounced at the level of a weak tendency. Conclusions. The anticonvulsant effect of digoxin when administered intragastrically and subcutaneously in mice with models of pentylenetetrazole-induced seizures and maximal electric shock is practically independent of the routeof administration. Digoxin has a pronounced anticonvulsant effect on the model of electrically induced seizures, and a moderate effect on the model of pentylenetetrazole seizures." @default.
• W4308785103 created "2022-11-15" @default.
• W4308785103 creator A5033152311 @default.
• W4308785103 creator A5049853768 @default.
• W4308785103 creator A5066618992 @default.
• W4308785103 creator A5082749405 @default.
• W4308785103 date "2022-11-07" @default.
• W4308785103 modified "2023-10-18" @default.
• W4308785103 title "The anticonvulsant effect of digoxin on basic models of primary generalized seizures does not depend on the route of administration" @default.
• W4308785103 doi "https://doi.org/10.24959/nphj.22.98" @default.
• W4308785103 hasPublicationYear "2022" @default.
• W4308785103 type Work @default.
• W4308785103 citedByCount "0" @default.
• W4308785103 crossrefType "journal-article" @default.
• W4308785103 hasAuthorship W4308785103A5033152311 @default.
• W4308785103 hasAuthorship W4308785103A5049853768 @default.
• W4308785103 hasAuthorship W4308785103A5066618992 @default.
• W4308785103 hasAuthorship W4308785103A5082749405 @default.
• W4308785103 hasBestOaLocation W43087851031 @default.
• W4308785103 hasConcept C118552586 @default.
• W4308785103 hasConcept C126322002 @default.
• W4308785103 hasConcept C127573956 @default.
• W4308785103 hasConcept C2775858608 @default.
• W4308785103 hasConcept C2776819090 @default.
• W4308785103 hasConcept C2777707475 @default.
• W4308785103 hasConcept C2778186239 @default.
• W4308785103 hasConcept C2778198053 @default.
• W4308785103 hasConcept C2778337148 @default.
• W4308785103 hasConcept C2779253243 @default.
• W4308785103 hasConcept C42219234 @default.
• W4308785103 hasConcept C71924100 @default.
• W4308785103 hasConcept C98274493 @default.
• W4308785103 hasConceptScore W4308785103C118552586 @default.
• W4308785103 hasConceptScore W4308785103C126322002 @default.
• W4308785103 hasConceptScore W4308785103C127573956 @default.
• W4308785103 hasConceptScore W4308785103C2775858608 @default.
• W4308785103 hasConceptScore W4308785103C2776819090 @default.
• W4308785103 hasConceptScore W4308785103C2777707475 @default.
• W4308785103 hasConceptScore W4308785103C2778186239 @default.
• W4308785103 hasConceptScore W4308785103C2778198053 @default.
• W4308785103 hasConceptScore W4308785103C2778337148 @default.
• W4308785103 hasConceptScore W4308785103C2779253243 @default.
• W4308785103 hasConceptScore W4308785103C42219234 @default.
• W4308785103 hasConceptScore W4308785103C71924100 @default.
• W4308785103 hasConceptScore W4308785103C98274493 @default.
• W4308785103 hasIssue "2" @default.
• W4308785103 hasLocation W43087851031 @default.
• W4308785103 hasOpenAccess W4308785103 @default.
• W4308785103 hasPrimaryLocation W43087851031 @default.
• W4308785103 hasRelatedWork W1980918385 @default.
• W4308785103 hasRelatedWork W2059075905 @default.
• W4308785103 hasRelatedWork W2067286606 @default.
• W4308785103 hasRelatedWork W2153335219 @default.
• W4308785103 hasRelatedWork W2411618962 @default.
• W4308785103 hasRelatedWork W2429723649 @default.
• W4308785103 hasRelatedWork W2463121170 @default.
• W4308785103 hasRelatedWork W2906906539 @default.
• W4308785103 hasRelatedWork W34455977 @default.
• W4308785103 hasRelatedWork W4308785103 @default.
• W4308785103 hasVolume "104" @default.
• W4308785103 isParatext "false" @default.
• W4308785103 isRetracted "false" @default.
• W4308785103 workType "article" @default.