Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308786656> ?p ?o ?g. }
- W4308786656 abstract "Abstract Cancer cells feature a resting membrane potential ( V m ) that is depolarized compared to normal cells, and express active ionic conductances, which factor directly in their pathophysiological behavior. Despite similarities to ‘excitable’ tissues, relatively little is known about cancer cell V m dynamics. Here high-throughput, cellular-resolution V m imaging reveals that V m fluctuates dynamically in several breast cancer cell lines compared to non-cancerous MCF-10A cells. We characterize V m fluctuations of hundreds of human triple-negative breast cancer MDA-MB-231 cells. By quantifying their Dynamic Electrical Signatures (DESs) through an unsupervised machine-learning protocol, we identify four classes ranging from noisy” to “blinking/waving“. The V m of MDA-MB-231 cells exhibits spontaneous, transient hyperpolarizations inhibited by the voltage-gated sodium channel blocker tetrodotoxin, and by calcium-activated potassium channel inhibitors apamin and iberiotoxin. The V m of MCF-10A cells is comparatively static, but fluctuations increase following treatment with transforming growth factor- β 1, a canonical inducer of the epithelial-to-mesenchymal transition. These data suggest that the ability to generate V m fluctuations may be a property of hybrid epithelial-mesenchymal cells or those originated from luminal progenitors." @default.
- W4308786656 created "2022-11-15" @default.
- W4308786656 creator A5011222818 @default.
- W4308786656 creator A5027208672 @default.
- W4308786656 creator A5030528567 @default.
- W4308786656 creator A5040167995 @default.
- W4308786656 creator A5042375232 @default.
- W4308786656 creator A5064969941 @default.
- W4308786656 creator A5070331479 @default.
- W4308786656 creator A5076914560 @default.
- W4308786656 date "2022-11-11" @default.
- W4308786656 modified "2023-10-18" @default.
- W4308786656 title "Voltage imaging reveals the dynamic electrical signatures of human breast cancer cells" @default.
- W4308786656 cites W1497499431 @default.
- W4308786656 cites W1541296013 @default.
- W4308786656 cites W1967293289 @default.
- W4308786656 cites W1972056075 @default.
- W4308786656 cites W1974638746 @default.
- W4308786656 cites W1979927071 @default.
- W4308786656 cites W1985400766 @default.
- W4308786656 cites W1987971958 @default.
- W4308786656 cites W1988505019 @default.
- W4308786656 cites W2011301426 @default.
- W4308786656 cites W2015159529 @default.
- W4308786656 cites W2024711707 @default.
- W4308786656 cites W2032013609 @default.
- W4308786656 cites W2032855201 @default.
- W4308786656 cites W2038706114 @default.
- W4308786656 cites W2044702943 @default.
- W4308786656 cites W2049656714 @default.
- W4308786656 cites W2052787194 @default.
- W4308786656 cites W2059149310 @default.
- W4308786656 cites W2063382533 @default.
- W4308786656 cites W2072292615 @default.
- W4308786656 cites W2082887122 @default.
- W4308786656 cites W2096283457 @default.
- W4308786656 cites W2107508846 @default.
- W4308786656 cites W2107919655 @default.
- W4308786656 cites W2108406026 @default.
- W4308786656 cites W2114016572 @default.
- W4308786656 cites W2114659222 @default.
- W4308786656 cites W2124366608 @default.
- W4308786656 cites W2134539328 @default.
- W4308786656 cites W2137753785 @default.
- W4308786656 cites W2165892338 @default.
- W4308786656 cites W2292180879 @default.
- W4308786656 cites W2500787525 @default.
- W4308786656 cites W2521545903 @default.
- W4308786656 cites W2523544603 @default.
- W4308786656 cites W2560367415 @default.
- W4308786656 cites W2593854821 @default.
- W4308786656 cites W2708584450 @default.
- W4308786656 cites W2891062823 @default.
- W4308786656 cites W2897276478 @default.
- W4308786656 cites W2905866485 @default.
- W4308786656 cites W2907471572 @default.
- W4308786656 cites W2911725508 @default.
- W4308786656 cites W2946765204 @default.
- W4308786656 cites W2951553920 @default.
- W4308786656 cites W2964363746 @default.
- W4308786656 cites W2967988901 @default.
- W4308786656 cites W2970997360 @default.
- W4308786656 cites W2974419380 @default.
- W4308786656 cites W2981169747 @default.
- W4308786656 cites W2981777910 @default.
- W4308786656 cites W2988532209 @default.
- W4308786656 cites W2994001074 @default.
- W4308786656 cites W3003584921 @default.
- W4308786656 cites W3020993277 @default.
- W4308786656 cites W3099878876 @default.
- W4308786656 cites W3103145119 @default.
- W4308786656 cites W3111521801 @default.
- W4308786656 cites W3165817854 @default.
- W4308786656 cites W3184639191 @default.
- W4308786656 cites W4308786656 @default.
- W4308786656 doi "https://doi.org/10.1038/s42003-022-04077-2" @default.
- W4308786656 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36369329" @default.
- W4308786656 hasPublicationYear "2022" @default.
- W4308786656 type Work @default.
- W4308786656 citedByCount "7" @default.
- W4308786656 countsByYear W43087866562022 @default.
- W4308786656 countsByYear W43087866562023 @default.
- W4308786656 crossrefType "journal-article" @default.
- W4308786656 hasAuthorship W4308786656A5011222818 @default.
- W4308786656 hasAuthorship W4308786656A5027208672 @default.
- W4308786656 hasAuthorship W4308786656A5030528567 @default.
- W4308786656 hasAuthorship W4308786656A5040167995 @default.
- W4308786656 hasAuthorship W4308786656A5042375232 @default.
- W4308786656 hasAuthorship W4308786656A5064969941 @default.
- W4308786656 hasAuthorship W4308786656A5070331479 @default.
- W4308786656 hasAuthorship W4308786656A5076914560 @default.
- W4308786656 hasBestOaLocation W43087866561 @default.
- W4308786656 hasConcept C121608353 @default.
- W4308786656 hasConcept C12554922 @default.
- W4308786656 hasConcept C126322002 @default.
- W4308786656 hasConcept C181911157 @default.
- W4308786656 hasConcept C185592680 @default.
- W4308786656 hasConcept C198826908 @default.
- W4308786656 hasConcept C502942594 @default.
- W4308786656 hasConcept C530470458 @default.