FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308786706> ?p ?o ?g. }

• W4308786706 endingPage "675" @default.
• W4308786706 startingPage "669" @default.
• W4308786706 abstract "Numerous epidemiological and preclinical studies have established a strong correlation between type 2 diabetes (T2DM) and cognitive impairment and T2DM is now established as an undisputable risk factor in different forms of dementia. However, the mechanisms underlying cognitive impairment in T2DM are still not fully understood. The temporal and spatial coupling between neuronal activity and cerebral blood flow (CBF) - neurovascular coupling (NVC) - is essential for normal brain function. Neuronal-derived nitric oxide (⦁NO) produced through the nNOS-NMDAr pathway, is recognized as a key messenger in NVC, especially in the hippocampus. Of note, impaired hippocampal perfusion in T2DM patients has been closely linked to learning and memory dysfunction. In this study, we aimed to investigate the functionality of NVC, in terms of neuronal-•NO signaling and spatial memory performance, in young Goto-Kakizaki (GK) rats, a non-obese model of T2DM. For that, we performed direct and simultaneous measurements of •NO concentration dynamics and microvascular CBF changes in the hippocampus upon glutamatergic activation. We found that limited •NO bioavailability, connected to shorter and faster •NO transients in response to glutamatergic neuronal activation, is associated with decreased hemodynamic responses and a decline in spatial memory performance. This evidence supports a close mechanistic association between neuronal-triggered •NO concentration dynamics in the hippocampus, local microvascular responses, and cognitive performance in young diabetic animals, establishing the functionality of NVC as a critical early factor to consider in the cascade of events leading to cognitive decline in T2DM. These results suggest that strategies capable to overcome the limited •NO bioavailability in early stages of T2DM and maintaining a functional NVC pathway may configure pertinent therapeutic approaches to mitigate the risk for cognitive impairment in T2DM." @default.
• W4308786706 created "2022-11-15" @default.
• W4308786706 creator A5047827363 @default.
• W4308786706 creator A5084936756 @default.
• W4308786706 creator A5088899608 @default.
• W4308786706 creator A5090186962 @default.
• W4308786706 date "2022-11-01" @default.
• W4308786706 modified "2023-10-14" @default.
• W4308786706 title "Impairment of neurovascular coupling in the hippocampus due to decreased nitric oxide bioavailability supports early cognitive dysfunction in type 2 diabetic rats" @default.
• W4308786706 cites W137145223 @default.
• W4308786706 cites W1453012560 @default.
• W4308786706 cites W1511302815 @default.
• W4308786706 cites W1595719516 @default.
• W4308786706 cites W1609584101 @default.
• W4308786706 cites W1871783318 @default.
• W4308786706 cites W1991125142 @default.
• W4308786706 cites W1998228658 @default.
• W4308786706 cites W2011190955 @default.
• W4308786706 cites W2012179131 @default.
• W4308786706 cites W2049971830 @default.
• W4308786706 cites W2056787190 @default.
• W4308786706 cites W2057301370 @default.
• W4308786706 cites W2087583510 @default.
• W4308786706 cites W2092670961 @default.
• W4308786706 cites W2102528806 @default.
• W4308786706 cites W2105696023 @default.
• W4308786706 cites W2105731956 @default.
• W4308786706 cites W2133933381 @default.
• W4308786706 cites W2158389868 @default.
• W4308786706 cites W2163234334 @default.
• W4308786706 cites W2166890974 @default.
• W4308786706 cites W2582244104 @default.
• W4308786706 cites W2583754769 @default.
• W4308786706 cites W2606197644 @default.
• W4308786706 cites W2767141466 @default.
• W4308786706 cites W2786962139 @default.
• W4308786706 cites W2804648738 @default.
• W4308786706 cites W2884234047 @default.
• W4308786706 cites W2884254074 @default.
• W4308786706 cites W2890494781 @default.
• W4308786706 cites W2900271671 @default.
• W4308786706 cites W2954458155 @default.
• W4308786706 cites W2966966909 @default.
• W4308786706 cites W2981650034 @default.
• W4308786706 cites W2986598981 @default.
• W4308786706 cites W3009656198 @default.
• W4308786706 cites W3158209701 @default.
• W4308786706 cites W3202465545 @default.
• W4308786706 cites W3208263134 @default.
• W4308786706 cites W4251966062 @default.
• W4308786706 cites W4283795102 @default.
• W4308786706 doi "https://doi.org/10.1016/j.freeradbiomed.2022.11.009" @default.
• W4308786706 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36372286" @default.
• W4308786706 hasPublicationYear "2022" @default.
• W4308786706 type Work @default.
• W4308786706 citedByCount "5" @default.
• W4308786706 countsByYear W43087867062023 @default.
• W4308786706 crossrefType "journal-article" @default.
• W4308786706 hasAuthorship W4308786706A5047827363 @default.
• W4308786706 hasAuthorship W4308786706A5084936756 @default.
• W4308786706 hasAuthorship W4308786706A5088899608 @default.
• W4308786706 hasAuthorship W4308786706A5090186962 @default.
• W4308786706 hasBestOaLocation W43087867061 @default.
• W4308786706 hasConcept C126322002 @default.
• W4308786706 hasConcept C148762608 @default.
• W4308786706 hasConcept C15744967 @default.
• W4308786706 hasConcept C157767197 @default.
• W4308786706 hasConcept C169760540 @default.
• W4308786706 hasConcept C170493617 @default.
• W4308786706 hasConcept C2779134260 @default.
• W4308786706 hasConcept C2779483572 @default.
• W4308786706 hasConcept C2780648746 @default.
• W4308786706 hasConcept C2781161787 @default.
• W4308786706 hasConcept C2984863031 @default.
• W4308786706 hasConcept C519581460 @default.
• W4308786706 hasConcept C61174792 @default.
• W4308786706 hasConcept C71924100 @default.
• W4308786706 hasConcept C74254510 @default.
• W4308786706 hasConceptScore W4308786706C126322002 @default.
• W4308786706 hasConceptScore W4308786706C148762608 @default.
• W4308786706 hasConceptScore W4308786706C15744967 @default.
• W4308786706 hasConceptScore W4308786706C157767197 @default.
• W4308786706 hasConceptScore W4308786706C169760540 @default.
• W4308786706 hasConceptScore W4308786706C170493617 @default.
• W4308786706 hasConceptScore W4308786706C2779134260 @default.
• W4308786706 hasConceptScore W4308786706C2779483572 @default.
• W4308786706 hasConceptScore W4308786706C2780648746 @default.
• W4308786706 hasConceptScore W4308786706C2781161787 @default.
• W4308786706 hasConceptScore W4308786706C2984863031 @default.
• W4308786706 hasConceptScore W4308786706C519581460 @default.
• W4308786706 hasConceptScore W4308786706C61174792 @default.
• W4308786706 hasConceptScore W4308786706C71924100 @default.
• W4308786706 hasConceptScore W4308786706C74254510 @default.
• W4308786706 hasFunder F4320327374 @default.
• W4308786706 hasFunder F4320334779 @default.
• W4308786706 hasFunder F4320335322 @default.
• W4308786706 hasLocation W43087867061 @default.
• W4308786706 hasLocation W43087867062 @default.

• next