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• W4308792181 abstract "Progressive functional deterioration in the cochlea is associated with age-related hearing loss (ARHL). However, the cellular and molecular basis underlying cochlear aging remains largely unknown. Here, we established a dynamic single-cell transcriptomic landscape of mouse cochlear aging, in which we characterized aging-associated transcriptomic changes in 27 different cochlear cell types across five different time points. Overall, our analysis pinpoints loss of proteostasis and elevated apoptosis as the hallmark features of cochlear aging, highlights unexpected age-related transcriptional fluctuations in intermediate cells localized in the stria vascularis (SV) and demonstrates that upregulation of endoplasmic reticulum (ER) chaperon protein HSP90AA1 mitigates ER stress-induced damages associated with aging. Our work suggests that targeting unfolded protein response pathways may help alleviate aging-related SV atrophy and hence delay the progression of ARHL." @default.
• W4308792181 created "2022-11-15" @default.
• W4308792181 creator A5003042472 @default.
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• W4308792181 creator A5091898557 @default.
• W4308792181 date "2022-11-11" @default.
• W4308792181 modified "2023-10-16" @default.
• W4308792181 title "Single-cell transcriptomic Atlas of mouse cochlear aging" @default.
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