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- W4308792212 abstract "Abstract Assessment of viral kinetics of SARS-CoV-2 may inform host immune responses to and transmission potential of the virus. We analyzed longitudinal data of RT-PCR tests conducted for symptomatic COVID-19 patients at confirmation and during hospital isolation in Hong Kong during three major epidemic waves, and modeled the temporal trajectories of viral burden in these patients. Our analysis demonstrated that a longer duration of viral shedding appeared in more severe and older cases. Vaccinated individuals with a breakthrough infection of Omicron BA.2 exhibited a lower viral burden than non-vaccinated Omicron cases in early days following onset and a shorter duration of viral shedding particularly in more recently vaccinated patients. The viral kinetics characterized in our study provided insight into further studies on host immune responses to SARS-CoV-2 infection, prognosis of COVID-19 patients as well as possible protective mechanisms of vaccination against infection and severe outcomes." @default.
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- W4308792212 date "2022-11-11" @default.
- W4308792212 modified "2023-10-03" @default.
- W4308792212 title "Viral shedding among symptomatic COVID-19 cases infected with the ancestral strain and Omicron BA.2" @default.
- W4308792212 doi "https://doi.org/10.21203/rs.3.rs-2258479/v1" @default.
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