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- W4308792939 abstract "ABSTRACT Structural metastability of viral capsids is pivotal for viruses to survive in harsh environments and to undergo timely conformational changes required for cell entry. Mammalian orthoreovirus (reovirus) is a model to study capsid metastability. Following initial disassembly of the reovirus particle mediated by proteases, a metastable intermediate called the infectious subvirion particle (ISVP) is generated. Using a σ1 monoreassortant virus, we recently showed that σ1 properties affect its encapsidation on particles and the metastability of ISVPs. How metastability is impacted by σ1 and whether the lower encapsidation level of σ1 is connected to this property is unknown. To define a correlation between encapsidation of σ1 and ISVP stability, we generated mutant viruses with single amino acid polymorphisms in σ1 or those that contain chimeric σ1 molecules composed of σ1 portions from Type 1 and Type 3 reovirus strains. We found that under most conditions where σ1 encapsidation on the particle was lower, ISVPs displayed lower stability. By separating wild-type particles based on the level of encapsidated σ1, we also found that lower σ1 encapsidation leads to lower ISVP stability. Characterization of mutant viruses selected for enhanced stability via a forward genetic approach also revealed that in some cases, σ1 properties influence stability without influencing σ1 encapsidation. These data indicate that σ1 can also influence ISVP stability independent of its level of incorporation. Together, our work reveals an underappreciated effect of the σ1 attachment protein on the properties of the reovirus capsid." @default.
- W4308792939 created "2022-11-15" @default.
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- W4308792939 date "2022-11-11" @default.
- W4308792939 modified "2023-09-27" @default.
- W4308792939 title "The reovirus σ1 attachment protein influences the stability of its entry intermediate" @default.
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- W4308792939 doi "https://doi.org/10.1101/2022.11.10.515810" @default.
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