Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308796572> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W4308796572 abstract "Aptamers are target-recognition molecules that bind with high affinity and specificity. These characteristics can be leveraged to control other molecules with signal-generation capability. For the system described herein, target recognition through an aptameric domain, Stem II of a modified hammerhead ribozyme, activates the self-cleaving ribozyme by stabilizing the initially unstructured construct. The cis-cleaving RNA acts at the junction of Stem III and Stem I, creating two cleavage products. The longer cleavage product primes an isothermal exponential amplification reaction (EXPAR) of the two similar catalytically active G-quadruplexes. Those resulting amplification products catalyze peroxidase reduction, which is coupled to the reduction of a colorimetric substrate with an output that the naked eye can detect. The 3-part system described in the present study improves detection modalities such as enzyme-linked immunosorbent assays (ELISAs) by producing a visually detectable signal for indicating the presence of as low as 0.5 µM theophylline in as little as 15 min." @default.
- W4308796572 created "2022-11-15" @default.
- W4308796572 date "2022-11-11" @default.
- W4308796572 modified "2023-09-26" @default.
- W4308796572 title "JoVE Video Dataset" @default.
- W4308796572 doi "https://doi.org/10.3791/64342-v" @default.
- W4308796572 hasPublicationYear "2022" @default.
- W4308796572 type Work @default.
- W4308796572 citedByCount "0" @default.
- W4308796572 crossrefType "journal-article" @default.
- W4308796572 hasConcept C104317684 @default.
- W4308796572 hasConcept C119128265 @default.
- W4308796572 hasConcept C119203544 @default.
- W4308796572 hasConcept C12554922 @default.
- W4308796572 hasConcept C128972844 @default.
- W4308796572 hasConcept C129312508 @default.
- W4308796572 hasConcept C151730666 @default.
- W4308796572 hasConcept C153911025 @default.
- W4308796572 hasConcept C158531540 @default.
- W4308796572 hasConcept C169663058 @default.
- W4308796572 hasConcept C175156509 @default.
- W4308796572 hasConcept C185592680 @default.
- W4308796572 hasConcept C21951064 @default.
- W4308796572 hasConcept C2779792011 @default.
- W4308796572 hasConcept C43369102 @default.
- W4308796572 hasConcept C43617362 @default.
- W4308796572 hasConcept C552990157 @default.
- W4308796572 hasConcept C55493867 @default.
- W4308796572 hasConcept C67705224 @default.
- W4308796572 hasConcept C70721500 @default.
- W4308796572 hasConcept C71240020 @default.
- W4308796572 hasConcept C76346623 @default.
- W4308796572 hasConcept C86803240 @default.
- W4308796572 hasConceptScore W4308796572C104317684 @default.
- W4308796572 hasConceptScore W4308796572C119128265 @default.
- W4308796572 hasConceptScore W4308796572C119203544 @default.
- W4308796572 hasConceptScore W4308796572C12554922 @default.
- W4308796572 hasConceptScore W4308796572C128972844 @default.
- W4308796572 hasConceptScore W4308796572C129312508 @default.
- W4308796572 hasConceptScore W4308796572C151730666 @default.
- W4308796572 hasConceptScore W4308796572C153911025 @default.
- W4308796572 hasConceptScore W4308796572C158531540 @default.
- W4308796572 hasConceptScore W4308796572C169663058 @default.
- W4308796572 hasConceptScore W4308796572C175156509 @default.
- W4308796572 hasConceptScore W4308796572C185592680 @default.
- W4308796572 hasConceptScore W4308796572C21951064 @default.
- W4308796572 hasConceptScore W4308796572C2779792011 @default.
- W4308796572 hasConceptScore W4308796572C43369102 @default.
- W4308796572 hasConceptScore W4308796572C43617362 @default.
- W4308796572 hasConceptScore W4308796572C552990157 @default.
- W4308796572 hasConceptScore W4308796572C55493867 @default.
- W4308796572 hasConceptScore W4308796572C67705224 @default.
- W4308796572 hasConceptScore W4308796572C70721500 @default.
- W4308796572 hasConceptScore W4308796572C71240020 @default.
- W4308796572 hasConceptScore W4308796572C76346623 @default.
- W4308796572 hasConceptScore W4308796572C86803240 @default.
- W4308796572 hasLocation W43087965721 @default.
- W4308796572 hasOpenAccess W4308796572 @default.
- W4308796572 hasPrimaryLocation W43087965721 @default.
- W4308796572 hasRelatedWork W1980738196 @default.
- W4308796572 hasRelatedWork W2001396871 @default.
- W4308796572 hasRelatedWork W2003381057 @default.
- W4308796572 hasRelatedWork W2007248361 @default.
- W4308796572 hasRelatedWork W2059946849 @default.
- W4308796572 hasRelatedWork W2082237923 @default.
- W4308796572 hasRelatedWork W2109473087 @default.
- W4308796572 hasRelatedWork W2351321056 @default.
- W4308796572 hasRelatedWork W3142544929 @default.
- W4308796572 hasRelatedWork W938861265 @default.
- W4308796572 isParatext "false" @default.
- W4308796572 isRetracted "false" @default.
- W4308796572 workType "article" @default.