Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308799145> ?p ?o ?g. }
- W4308799145 endingPage "104398" @default.
- W4308799145 startingPage "104398" @default.
- W4308799145 abstract "This study investigated the bioactive compounds, anti-inflammatory, anti-nociceptive, and antioxidant properties of the ethanolic leaf fraction of Sida linifolia (ELFSL). The in vitro anti-inflammatory study employed membrane stabilization, phospholipase A2, platelet aggregation, albumin denaturation, and protease inhibition assays. Intraperitoneal injection of freshly prepared carrageenan solution (0.1 mL of 0.01 g/mL), undiluted egg albumin (0.1 mL), acetic acid (0.6 % (v/v) (10 mL/kg bw), and formalin solution (0.02 mL of 1 % v/v) into mice hind paw, were used to evaluate the anti-inflammatory and anti-nociceptive mechanisms, respectively. In vitro antioxidant potentials were determined using 1,1-Diphenyl-2-picryl-hydrazyl (DPPH), nitric oxide (NO), ferric reducing power (FRAP), and total antioxidant capacity (TAC) assays. Varying quantities of flavonoids, phenols, tannins, saponins, terpenoids, steroids, and alkaloids, were detected in the fraction. GC-FID phytochemical profiling of ELFSL revealed a high level of epicatechin, moderate levels of catechin, kaempferol, flavone, naringenin, rutin flavanones, tannins, sapogenins, proanthocyanidin, and steroids, and small amounts of sparteine, resveratrol, and lunamarine. The ELFSL exerted excellent dose-dependent in vitro anti-inflammatory activities comparable with standard drugs (aspirin/prednisolone). The LD50 test showed safety up to 5000 mg/kg body weight (per oral) ELFSL. Interestingly, mice pre-administered various doses (200, 400, 600 mg/kg bw, po) of ELFSL showed significant (P < 0.05) reduction in edema, writhing, and time spent licking paw in all phases compared with control and were at par with 100 mg/kg bw (po) aspirin. The result also registered good concentration-dependent antioxidant potentials for ELFSL and was comparable to standards (gallic acid, butylated hydroxytoluene, and ascorbic acid). These imply that ELFSL possesses excellent antioxidant, anti-inflammatory, and anti-nociceptive potentials mediated by peripheral and central mechanisms." @default.
- W4308799145 created "2022-11-15" @default.
- W4308799145 creator A5020551807 @default.
- W4308799145 creator A5036272020 @default.
- W4308799145 creator A5037580966 @default.
- W4308799145 creator A5041133294 @default.
- W4308799145 creator A5048445893 @default.
- W4308799145 creator A5054847803 @default.
- W4308799145 creator A5057359082 @default.
- W4308799145 creator A5058924892 @default.
- W4308799145 creator A5065026696 @default.
- W4308799145 creator A5067401179 @default.
- W4308799145 creator A5068740333 @default.
- W4308799145 creator A5072278023 @default.
- W4308799145 creator A5072493007 @default.
- W4308799145 creator A5073887019 @default.
- W4308799145 creator A5076135554 @default.
- W4308799145 creator A5080902424 @default.
- W4308799145 creator A5086908879 @default.
- W4308799145 creator A5089449417 @default.
- W4308799145 date "2023-01-01" @default.
- W4308799145 modified "2023-09-30" @default.
- W4308799145 title "Bioactive compounds, anti-inflammatory, anti-nociceptive and antioxidant potentials of ethanolic leaf fraction of Sida linifolia L. (Malvaceae)" @default.
- W4308799145 cites W1471639501 @default.
- W4308799145 cites W1793192921 @default.
- W4308799145 cites W1882908591 @default.
- W4308799145 cites W1913970538 @default.
- W4308799145 cites W1920695003 @default.
- W4308799145 cites W1943272175 @default.
- W4308799145 cites W1966700699 @default.
- W4308799145 cites W1967637768 @default.
- W4308799145 cites W1971005475 @default.
- W4308799145 cites W1971093836 @default.
- W4308799145 cites W1971322298 @default.
- W4308799145 cites W1974082153 @default.
- W4308799145 cites W1977704347 @default.
- W4308799145 cites W1979906109 @default.
- W4308799145 cites W1981819970 @default.
- W4308799145 cites W1983964395 @default.
- W4308799145 cites W1994515390 @default.
- W4308799145 cites W1999992247 @default.
- W4308799145 cites W2003310767 @default.
- W4308799145 cites W2004121149 @default.
- W4308799145 cites W2005124825 @default.
- W4308799145 cites W2008033400 @default.
- W4308799145 cites W2008574207 @default.
- W4308799145 cites W2009345240 @default.
- W4308799145 cites W2010248759 @default.
- W4308799145 cites W2010270875 @default.
- W4308799145 cites W2011336591 @default.
- W4308799145 cites W2013270458 @default.
- W4308799145 cites W2013980575 @default.
- W4308799145 cites W2021910621 @default.
- W4308799145 cites W2031070839 @default.
- W4308799145 cites W2033588393 @default.
- W4308799145 cites W2036513848 @default.
- W4308799145 cites W2039335100 @default.
- W4308799145 cites W2041547286 @default.
- W4308799145 cites W2042464457 @default.
- W4308799145 cites W2054115898 @default.
- W4308799145 cites W2054206661 @default.
- W4308799145 cites W2056516428 @default.
- W4308799145 cites W2067670322 @default.
- W4308799145 cites W2070726031 @default.
- W4308799145 cites W2072322888 @default.
- W4308799145 cites W2073404654 @default.
- W4308799145 cites W2077013120 @default.
- W4308799145 cites W2078328099 @default.
- W4308799145 cites W2080058698 @default.
- W4308799145 cites W2087530198 @default.
- W4308799145 cites W2102783779 @default.
- W4308799145 cites W2107680821 @default.
- W4308799145 cites W2116597521 @default.
- W4308799145 cites W2118494595 @default.
- W4308799145 cites W2119364523 @default.
- W4308799145 cites W2127903487 @default.
- W4308799145 cites W2129935236 @default.
- W4308799145 cites W2132589733 @default.
- W4308799145 cites W2135919238 @default.
- W4308799145 cites W2140348825 @default.
- W4308799145 cites W2144003426 @default.
- W4308799145 cites W2151528138 @default.
- W4308799145 cites W2160053026 @default.
- W4308799145 cites W2164053688 @default.
- W4308799145 cites W2190649990 @default.
- W4308799145 cites W2295677386 @default.
- W4308799145 cites W2313847629 @default.
- W4308799145 cites W2335050049 @default.
- W4308799145 cites W2342925175 @default.
- W4308799145 cites W2406836073 @default.
- W4308799145 cites W2542750231 @default.
- W4308799145 cites W2560792979 @default.
- W4308799145 cites W2565383127 @default.
- W4308799145 cites W2583373704 @default.
- W4308799145 cites W2589631034 @default.
- W4308799145 cites W2597887974 @default.
- W4308799145 cites W2620708336 @default.
- W4308799145 cites W2742556528 @default.