Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308803181> ?p ?o ?g. }
- W4308803181 abstract "The present study is aimed to investigate the antioxidative potential and ameliorative effects of Lens culinaris Medikus sprouts hydroalcoholic extract (LSHE) on CCl4-induced oxidative stress in rats. The research has been carried out in two successive stages. Firstly, the highest phenolic content and antioxidant activity of L. culinaris sprouts were assessed at 20 ± 1°C and 90-93% RH during sprouting. Total phenolic content (TPC), total carotenoids (TC), total flavonoids (TF), total flavonols (TFL), DPPH-RSA, and vitamin C contents of L. culinaris seeds and 6-days sprouts were determined. Subsequently, phenolics by HPLC analysis of L. culinaris seeds, 3rd and 6th-day sprouts were identified and quantified. Results indicated that 6th-day sprouts contained considerable phenolics with superior antioxidant capacity, thus selected to be examined for biological activity in a rat's module consisting of five groups. G1, normal rats orally received distilled water. G2 received 1.0 mL kg-1 of CCl4 and olive oil (1:1) intraperitoneally (i.p.) twice a week. G3 received CCl4 (i.p.) and 50 mg GAE kg-1 of LSHE daily/orally. G4 received CCl4 (i.p.) 100 mg kg-1 of LSHE orally/daily. G5 (reference group) treated by intramuscular injection (i.m.) of vit. E+Selenium (Vit. E+Se, 50 mg kg-1 twice a week). The weight gain, relative weight of organs, hypoglycemic and hypolipidemic efficiencies, liver's and kidneys' functions, and antioxidant biomarkers were examined. LSHE enhanced the weight gain recovery % and significantly reduced fasting blood glucose. The hypolipidemic effect of LSHE was dramatically reduced triglycerides (TG), total cholesterol (CHO), high- and low-density lipoproteins (HDL-c and LDL-c), and very-low-density lipoproteins (VLDL-c). Administration of 50 and 100 LSHE mg kg-1 ameliorated liver and kidney function in dose-dependent manure. Intriguingly, LSHE considerably reduced malondialdehyde (MDA) while significantly raising reduced glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT) in a dose-dependent manner. In conclusion, biochemical examinations confirmed the therapeutic efficacy of LSHE as a functional product. It encouraged us to recommend L. culinaris sprout production for attenuating hepatotoxicity and nephrotoxicity, as well as being beneficial and profitable for controlling oxidative stress complications." @default.
- W4308803181 created "2022-11-15" @default.
- W4308803181 creator A5036354495 @default.
- W4308803181 creator A5044328263 @default.
- W4308803181 creator A5048932340 @default.
- W4308803181 creator A5051363355 @default.
- W4308803181 creator A5061654385 @default.
- W4308803181 creator A5067522911 @default.
- W4308803181 creator A5068443309 @default.
- W4308803181 creator A5070281423 @default.
- W4308803181 creator A5086131963 @default.
- W4308803181 creator A5090253825 @default.
- W4308803181 creator A5090538245 @default.
- W4308803181 date "2022-11-11" @default.
- W4308803181 modified "2023-10-09" @default.
- W4308803181 title "Antioxidative potential and ameliorative effects of green lentil (Lens culinaris M.) sprouts against CCl4-induced oxidative stress in rats" @default.
- W4308803181 cites W1541266357 @default.
- W4308803181 cites W1543860345 @default.
- W4308803181 cites W1640123358 @default.
- W4308803181 cites W1827407499 @default.
- W4308803181 cites W1831301545 @default.
- W4308803181 cites W191793640 @default.
- W4308803181 cites W1920105142 @default.
- W4308803181 cites W1952547209 @default.
- W4308803181 cites W1964623470 @default.
- W4308803181 cites W1975473360 @default.
- W4308803181 cites W1977882271 @default.
- W4308803181 cites W1979529568 @default.
- W4308803181 cites W1983310681 @default.
- W4308803181 cites W1994015005 @default.
- W4308803181 cites W1997317149 @default.
- W4308803181 cites W1998824537 @default.
- W4308803181 cites W2003450091 @default.
- W4308803181 cites W2015707904 @default.
- W4308803181 cites W2017602185 @default.
- W4308803181 cites W2018223829 @default.
- W4308803181 cites W2021722567 @default.
- W4308803181 cites W2023706271 @default.
- W4308803181 cites W2028676438 @default.
- W4308803181 cites W2029494903 @default.
- W4308803181 cites W2029623721 @default.
- W4308803181 cites W2039648260 @default.
- W4308803181 cites W2041679184 @default.
- W4308803181 cites W2044638222 @default.
- W4308803181 cites W2047924394 @default.
- W4308803181 cites W2051245595 @default.
- W4308803181 cites W2051773667 @default.
- W4308803181 cites W2055568709 @default.
- W4308803181 cites W2058326486 @default.
- W4308803181 cites W2060940273 @default.
- W4308803181 cites W2061470880 @default.
- W4308803181 cites W2066210709 @default.
- W4308803181 cites W2068634811 @default.
- W4308803181 cites W2076014957 @default.
- W4308803181 cites W2089074970 @default.
- W4308803181 cites W2093538362 @default.
- W4308803181 cites W2097555085 @default.
- W4308803181 cites W2116404316 @default.
- W4308803181 cites W2159974055 @default.
- W4308803181 cites W2167543749 @default.
- W4308803181 cites W2169654939 @default.
- W4308803181 cites W2171095873 @default.
- W4308803181 cites W2184248865 @default.
- W4308803181 cites W2184503219 @default.
- W4308803181 cites W2266929960 @default.
- W4308803181 cites W2313847629 @default.
- W4308803181 cites W2340483098 @default.
- W4308803181 cites W2469059022 @default.
- W4308803181 cites W2511703138 @default.
- W4308803181 cites W2520874741 @default.
- W4308803181 cites W2526995645 @default.
- W4308803181 cites W2550897553 @default.
- W4308803181 cites W2580776341 @default.
- W4308803181 cites W2740695644 @default.
- W4308803181 cites W2765284193 @default.
- W4308803181 cites W2767464756 @default.
- W4308803181 cites W2887310302 @default.
- W4308803181 cites W2912990049 @default.
- W4308803181 cites W2933246901 @default.
- W4308803181 cites W2973558649 @default.
- W4308803181 cites W3034781447 @default.
- W4308803181 cites W3088170696 @default.
- W4308803181 cites W3109236997 @default.
- W4308803181 cites W3138958551 @default.
- W4308803181 cites W3195708785 @default.
- W4308803181 cites W4200333239 @default.
- W4308803181 cites W4221093214 @default.
- W4308803181 doi "https://doi.org/10.3389/fnut.2022.1029793" @default.
- W4308803181 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36438775" @default.
- W4308803181 hasPublicationYear "2022" @default.
- W4308803181 type Work @default.
- W4308803181 citedByCount "1" @default.
- W4308803181 crossrefType "journal-article" @default.
- W4308803181 hasAuthorship W4308803181A5036354495 @default.
- W4308803181 hasAuthorship W4308803181A5044328263 @default.
- W4308803181 hasAuthorship W4308803181A5048932340 @default.
- W4308803181 hasAuthorship W4308803181A5051363355 @default.
- W4308803181 hasAuthorship W4308803181A5061654385 @default.
- W4308803181 hasAuthorship W4308803181A5067522911 @default.
- W4308803181 hasAuthorship W4308803181A5068443309 @default.