FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308803602> ?p ?o ?g. }

• W4308803602 abstract "The emergence of Sin Nombre orthohantavirus, an etiological agent of hantavirus cardiopulmonary syndrome, exacerbates the situation and imposes a heavy financial burden on healthcare organizations. Multidrug-resistant forms of the disease are prevalent, and there is currently no licensed commercial vaccine. Due to the numerous limitations of experimental vaccines, vaccines against various bacterial and viral diseases have developed via computational vaccine design. Several subtractive proteomics, immunoinformatics, docking, and simulation approaches were used in this study to develop a multi-epitope–based vaccine against Sin Nombre orthohantavirus. One possible antigenic protein—the glycoprotein precursor of surface glycoproteins (accession number &gt;AAC42202.1)—was selected as a candidate for B cell–derived T cell epitopes mapping the detailed analysis of the core genome. Among the predicted epitopes, four epitopes (QVDWTKKSST, GLAASPPHL, SSYSYRRKLV, and MESGWSDTA), which were probably antigenic, nonallergenic, nontoxic, and water soluble, were used in the multi-epitope vaccine’s construction. The shortlisted epitopes have the potency to cover 99.78% of the world’s population, 97.93% of the Chinese population, and 97.36% of the Indian population. The epitopes were connected through AAY linkers and joined with &gt;50S ribosomal adjuvant to enhance their efficacy. The vaccine comprises 182 amino acids with a molecular weight of 19.03770 kDa and an instability index of 26.52, indicating that the protein is stable. A molecular docking study revealed that the vaccine has a good binding affinity with TLR-4 and TLR-8, which is vital for inducing the immune system. Top-1 docked complexes of vaccine- TLR-4 and TLR-8 with the lowest binding energy of -12.52 kc/mol and -5.42 kc/mol, respectively, were considered for molecular dynamic simulation analysis. Furthermore, we predicted that the docked complexes are properly stable throughout simulation time in both normal mode and AMBER-based simulation analysis. The MMGBSA analysis calculated -122.17 and -125.4 net binding energies for the TLR-8- and TLR4-vaccine complexes, respectively, while the MMPBSA analysis estimated -115.63 and -118.19 for the TLR-8- and TLR4-vaccine complex, respectively, confirming that the binding stability with receptors is stable, which is important for inducing a strong response. However, the current work is computation-based, so experimental validation is highly recommended." @default.
• W4308803602 created "2022-11-15" @default.
• W4308803602 creator A5055129073 @default.
• W4308803602 date "2022-11-11" @default.
• W4308803602 modified "2023-10-05" @default.
• W4308803602 title "Integrativesubtractive proteomics, immunoinformatics, docking, and simulation approaches reveal candidate vaccine against Sin Nombre orthohantavirus" @default.
• W4308803602 cites W1968984443 @default.
• W4308803602 cites W1971661668 @default.
• W4308803602 cites W1981140589 @default.
• W4308803602 cites W2015176909 @default.
• W4308803602 cites W2050717189 @default.
• W4308803602 cites W2053707749 @default.
• W4308803602 cites W2078459181 @default.
• W4308803602 cites W2093381148 @default.
• W4308803602 cites W2095719702 @default.
• W4308803602 cites W2096495474 @default.
• W4308803602 cites W2097606916 @default.
• W4308803602 cites W2100561975 @default.
• W4308803602 cites W2102367710 @default.
• W4308803602 cites W2131900949 @default.
• W4308803602 cites W2132252052 @default.
• W4308803602 cites W2151460035 @default.
• W4308803602 cites W2163667267 @default.
• W4308803602 cites W2183933146 @default.
• W4308803602 cites W2789267025 @default.
• W4308803602 cites W2993711598 @default.
• W4308803602 cites W3024020200 @default.
• W4308803602 cites W3035260101 @default.
• W4308803602 cites W3089763176 @default.
• W4308803602 cites W3090677763 @default.
• W4308803602 cites W3126130796 @default.
• W4308803602 cites W3131093316 @default.
• W4308803602 cites W3154494853 @default.
• W4308803602 cites W3155092015 @default.
• W4308803602 cites W3164601414 @default.
• W4308803602 cites W3190009919 @default.
• W4308803602 cites W3204941160 @default.
• W4308803602 cites W4210293359 @default.
• W4308803602 cites W4214525167 @default.
• W4308803602 cites W4220896491 @default.
• W4308803602 cites W4224310063 @default.
• W4308803602 cites W4225403313 @default.
• W4308803602 cites W4226199157 @default.
• W4308803602 cites W4244736178 @default.
• W4308803602 cites W4283370212 @default.
• W4308803602 cites W4285007111 @default.
• W4308803602 doi "https://doi.org/10.3389/fimmu.2022.1022159" @default.
• W4308803602 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36439095" @default.
• W4308803602 hasPublicationYear "2022" @default.
• W4308803602 type Work @default.
• W4308803602 citedByCount "0" @default.
• W4308803602 crossrefType "journal-article" @default.
• W4308803602 hasAuthorship W4308803602A5055129073 @default.
• W4308803602 hasBestOaLocation W43088036021 @default.
• W4308803602 hasConcept C108625454 @default.
• W4308803602 hasConcept C147483822 @default.
• W4308803602 hasConcept C159047783 @default.
• W4308803602 hasConcept C159110408 @default.
• W4308803602 hasConcept C195616568 @default.
• W4308803602 hasConcept C203014093 @default.
• W4308803602 hasConcept C22070199 @default.
• W4308803602 hasConcept C2777863537 @default.
• W4308803602 hasConcept C2780441014 @default.
• W4308803602 hasConcept C2908647359 @default.
• W4308803602 hasConcept C41685203 @default.
• W4308803602 hasConcept C54355233 @default.
• W4308803602 hasConcept C70721500 @default.
• W4308803602 hasConcept C71924100 @default.
• W4308803602 hasConcept C86803240 @default.
• W4308803602 hasConcept C99454951 @default.
• W4308803602 hasConceptScore W4308803602C108625454 @default.
• W4308803602 hasConceptScore W4308803602C147483822 @default.
• W4308803602 hasConceptScore W4308803602C159047783 @default.
• W4308803602 hasConceptScore W4308803602C159110408 @default.
• W4308803602 hasConceptScore W4308803602C195616568 @default.
• W4308803602 hasConceptScore W4308803602C203014093 @default.
• W4308803602 hasConceptScore W4308803602C22070199 @default.
• W4308803602 hasConceptScore W4308803602C2777863537 @default.
• W4308803602 hasConceptScore W4308803602C2780441014 @default.
• W4308803602 hasConceptScore W4308803602C2908647359 @default.
• W4308803602 hasConceptScore W4308803602C41685203 @default.
• W4308803602 hasConceptScore W4308803602C54355233 @default.
• W4308803602 hasConceptScore W4308803602C70721500 @default.
• W4308803602 hasConceptScore W4308803602C71924100 @default.
• W4308803602 hasConceptScore W4308803602C86803240 @default.
• W4308803602 hasConceptScore W4308803602C99454951 @default.
• W4308803602 hasLocation W43088036021 @default.
• W4308803602 hasLocation W43088036022 @default.
• W4308803602 hasLocation W43088036023 @default.
• W4308803602 hasOpenAccess W4308803602 @default.
• W4308803602 hasPrimaryLocation W43088036021 @default.
• W4308803602 hasRelatedWork W1652583994 @default.
• W4308803602 hasRelatedWork W1755417734 @default.
• W4308803602 hasRelatedWork W2008201381 @default.
• W4308803602 hasRelatedWork W2044405416 @default.
• W4308803602 hasRelatedWork W2050101049 @default.
• W4308803602 hasRelatedWork W2053370301 @default.
• W4308803602 hasRelatedWork W2289160872 @default.
• W4308803602 hasRelatedWork W2655519188 @default.
• W4308803602 hasRelatedWork W3200667319 @default.

• next