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• W4308804123 startingPage "105286" @default.
• W4308804123 abstract "Bisphenol F (BPF, 4,4′-methylenediphenol) has recently been selected as an alternative to bisphenol A (BPA), which is used in the manufacturing of polycarbonates and epoxy resins. This study aimed to investigate the general, and reproductive/developmental effects of BPF. Therefore, BPF at dose levels of 0, 1, 5, 20, and 100 mg/kg/day was administered daily by oral gavage to Sprague-Dawley rats during the pre-mating, mating, gestation, and early lactation periods, and reproductive and developmental toxicities including general systemic toxicities were investigated. A decrease in body weight and food consumption was observed in the female rats treated with BPF at 20 and 100 mg/kg/day during the pre-mating and gestation periods. Additionally, gamma glutamyl transpeptidase levels were increased in the female rats administered 100 mg/kg/day. At 100 mg/kg/day, ovarian weight decreased and vaginal mucification increased according to a necropsy and histopathological examination, respectively. Moreover, the number of implantation sites and litter size decreased at 100 mg/kg/day. However, no significant BPF-related changes were observed in the male rats. Based on the results of this study, the no-observed-adverse-effect levels (NOAELs) of BPF for general systemic and reproductive effects were 5 and 20 mg/kg/day, respectively." @default.
• W4308804123 created "2022-11-15" @default.
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• W4308804123 date "2022-12-01" @default.
• W4308804123 modified "2023-09-27" @default.
• W4308804123 title "Reproductive and developmental toxicity screening of bisphenol F by oral gavage in rats" @default.
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• W4308804123 doi "https://doi.org/10.1016/j.yrtph.2022.105286" @default.
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