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Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308804784> ?p ?o ?g. }

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• W4308804784 abstract "Herpes simplex virus 1 (HSV-1) has been widely used to treat various cancers, but its efficacy is limited. Studies indicated that combining HSV-1 and chemotherapy drugs can effectively improve the lethality of HSV-1 in tumor cells, which has a synergistic effect. Here, we explored the oncolytic effect and mechanism of bortezomib and HSV-1 on colorectal cancer cells, HCT116 and Caco-2. First, we selected four drugs to detect cell viability and found that the strongest HSV-1-promoting effect was achieved using bortezomib + HSV-1 treatment. Bortezomib combined with HSV-1 treatment significantly upregulated the expression of heat shock proteins, endoplasmic reticulum stress-related proteins and apoptosis-related proteins, while Bcl-2 was downregulated. JC-1 staining revealed that combining bortezomib and HSV-1 promotes cell apoptosis. In addition, bortezomib + oHSV-1 treatment effectively inhibit tumor growth. These results indicate that bortezomib combined with HSV-1 induce intense endoplasmic reticulum stress and activate the caspase-12 apoptosis pathway, killing tumor cells." @default.
• W4308804784 created "2022-11-15" @default.
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• W4308804784 date "2023-01-01" @default.
• W4308804784 modified "2023-10-16" @default.
• W4308804784 title "Targeting proteasome enhances anticancer activity of oncolytic HSV-1 in colorectal cancer" @default.
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• W4308804784 doi "https://doi.org/10.1016/j.virol.2022.11.002" @default.
• W4308804784 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36434905" @default.
• W4308804784 hasPublicationYear "2023" @default.
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