Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308804847> ?p ?o ?g. }
- W4308804847 endingPage "105540" @default.
- W4308804847 startingPage "105540" @default.
- W4308804847 abstract "CD47 is an ubiquitously expressed surface molecule with significant impact on immune responses. However, its role for antiviral immunity is not fully understood. Here, we revealed that the expression of CD47 on immune cells seemed to disturb the antiviral immune response as CD47-deficient mice (CD47−/−) showed an augmented clearance of influenza A virus (IAV). Specifically, we have shown that enhanced viral clearance is mediated by alveolar macrophages (aMФ). Although aMФ displayed upregulation of CD47 expression during IAV infection in wildtype mice, depletion of aMФ in CD47−/− mice during IAV infection reversed the augmented viral clearance. We have also demonstrated that CD47 restricts hemoglobin (HB) expression in aMФ after IAV and severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection, with HB showing antiviral properties by enhancing the IFN-β response. Our study showed a negative role for CD47 during antiviral immune responses in the lung by confining HB expression in aMФ." @default.
- W4308804847 created "2022-11-15" @default.
- W4308804847 creator A5011041473 @default.
- W4308804847 creator A5016044284 @default.
- W4308804847 creator A5028735927 @default.
- W4308804847 creator A5044866194 @default.
- W4308804847 creator A5047589391 @default.
- W4308804847 creator A5054894785 @default.
- W4308804847 creator A5056781464 @default.
- W4308804847 creator A5060304095 @default.
- W4308804847 creator A5068954911 @default.
- W4308804847 creator A5082966360 @default.
- W4308804847 creator A5089752592 @default.
- W4308804847 creator A5090817370 @default.
- W4308804847 date "2022-12-01" @default.
- W4308804847 modified "2023-10-14" @default.
- W4308804847 title "CD47 restricts antiviral function of alveolar macrophages during influenza virus infection" @default.
- W4308804847 cites W1519679473 @default.
- W4308804847 cites W1575690521 @default.
- W4308804847 cites W1577297332 @default.
- W4308804847 cites W1631519520 @default.
- W4308804847 cites W1920011500 @default.
- W4308804847 cites W1963688157 @default.
- W4308804847 cites W1966157617 @default.
- W4308804847 cites W1966217032 @default.
- W4308804847 cites W1971063170 @default.
- W4308804847 cites W1973433801 @default.
- W4308804847 cites W1974138511 @default.
- W4308804847 cites W1975857445 @default.
- W4308804847 cites W1979158913 @default.
- W4308804847 cites W1997653917 @default.
- W4308804847 cites W2003406245 @default.
- W4308804847 cites W2007100673 @default.
- W4308804847 cites W2013533654 @default.
- W4308804847 cites W2019453934 @default.
- W4308804847 cites W2032714108 @default.
- W4308804847 cites W2047948762 @default.
- W4308804847 cites W2055724502 @default.
- W4308804847 cites W2059821412 @default.
- W4308804847 cites W2077016453 @default.
- W4308804847 cites W2093093158 @default.
- W4308804847 cites W2100694528 @default.
- W4308804847 cites W2104730345 @default.
- W4308804847 cites W2110882632 @default.
- W4308804847 cites W2114443908 @default.
- W4308804847 cites W2120579640 @default.
- W4308804847 cites W2124496335 @default.
- W4308804847 cites W2154434805 @default.
- W4308804847 cites W2155517069 @default.
- W4308804847 cites W2158310768 @default.
- W4308804847 cites W2166479101 @default.
- W4308804847 cites W2167279371 @default.
- W4308804847 cites W2168324886 @default.
- W4308804847 cites W2259285103 @default.
- W4308804847 cites W2346201231 @default.
- W4308804847 cites W2407153908 @default.
- W4308804847 cites W2510945666 @default.
- W4308804847 cites W2594014934 @default.
- W4308804847 cites W2603153405 @default.
- W4308804847 cites W2605076107 @default.
- W4308804847 cites W2775569101 @default.
- W4308804847 cites W2803619785 @default.
- W4308804847 cites W2906099433 @default.
- W4308804847 cites W2948523879 @default.
- W4308804847 cites W2964081236 @default.
- W4308804847 cites W3015969228 @default.
- W4308804847 cites W3036941849 @default.
- W4308804847 cites W3091907608 @default.
- W4308804847 cites W3180301457 @default.
- W4308804847 cites W3188123482 @default.
- W4308804847 cites W406736399 @default.
- W4308804847 cites W4210843726 @default.
- W4308804847 cites W4210997720 @default.
- W4308804847 cites W4234370261 @default.
- W4308804847 cites W1900024790 @default.
- W4308804847 doi "https://doi.org/10.1016/j.isci.2022.105540" @default.
- W4308804847 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36437873" @default.
- W4308804847 hasPublicationYear "2022" @default.
- W4308804847 type Work @default.
- W4308804847 citedByCount "1" @default.
- W4308804847 countsByYear W43088048472023 @default.
- W4308804847 crossrefType "journal-article" @default.
- W4308804847 hasAuthorship W4308804847A5011041473 @default.
- W4308804847 hasAuthorship W4308804847A5016044284 @default.
- W4308804847 hasAuthorship W4308804847A5028735927 @default.
- W4308804847 hasAuthorship W4308804847A5044866194 @default.
- W4308804847 hasAuthorship W4308804847A5047589391 @default.
- W4308804847 hasAuthorship W4308804847A5054894785 @default.
- W4308804847 hasAuthorship W4308804847A5056781464 @default.
- W4308804847 hasAuthorship W4308804847A5060304095 @default.
- W4308804847 hasAuthorship W4308804847A5068954911 @default.
- W4308804847 hasAuthorship W4308804847A5082966360 @default.
- W4308804847 hasAuthorship W4308804847A5089752592 @default.
- W4308804847 hasAuthorship W4308804847A5090817370 @default.
- W4308804847 hasBestOaLocation W43088048471 @default.
- W4308804847 hasConcept C104317684 @default.
- W4308804847 hasConcept C127561419 @default.
- W4308804847 hasConcept C136449434 @default.