FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308805156> ?p ?o ?g. }

• W4308805156 abstract "To date, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has reportedly infected over 630 million people, leading to the deaths of more than 6.5 million people. Despite expansive investigation of its pathogenesis and the development of vaccines and therapeutics, research in preclinical models must continue to ensure that we can combat the continuing COVID-19 and future pandemics. Two exemplary animal models – Syrian golden hamsters and K18-promoter-driven human ACE2-expressing (K18-hACE2) mice – recapitulate the human pathology, immune response and clinical manifestations of COVID-19, and are also accessible with low cost. However, there are vast differences in the severity of disease in these models, with mild clinical manifestations in the hamsters and high lethality in the mice.Jeong and colleagues intranasally infected Syrian golden hamsters and K18-hACE2 mice with the same dose of SARS-CoV-2, resulting in mild clinical signs in hamsters, such as minor decreases in body weight, and severe manifestations in mice, leading to death by 7 days post-infection (dpi). The authors thoroughly interrogated the infection in these animals to elucidate the mechanisms behind the differing clinical outcomes. They used in situ hybridization imaging to show that SARS-CoV-2 infection was mainly confined to microvillar club (∼88%) and ciliated (∼12%) cell subsets in the bronchus region of hamsters. These infected cells were rapidly eliminated, with high levels of cell death apparent at 2 dpi. By 5 dpi, in the hamsters, the infected area was highly infiltrated with B and CD8+ T cells, which are important for clearing infected cells. Surprisingly, lung pathology was more severe in hamsters than in mice at 5 and 7 dpi, with imaging revealing markers of bronchioalveolar adenoma and bronchopneumonia in hamsters. However, after 7 dpi, pulmonary lesions and adaptive immune cell accumulation were ameliorated, with only regenerative hyperplasia apparent in the bronchus at 14 dpi. Overall, the initial robust immune response was key in limiting and resolving SARS-CoV-2 infection in hamsters.By contrast, SARS-CoV-2 primarily infected the alveolar area of mouse lungs, with type 1 alveolar cells comprising roughly 97% of total infected cells, and very few infected cells were eliminated. The infection also spread to distal organs, such as the spleen at 2 dpi and the brain at 7 dpi, which resulted in inflammatory cell death and histopathological damage in several organs. B and T cells progressively accumulated in the mouse lungs up until death at 7 dpi, but the extent of infiltration was much lower than that in hamsters at early time points. The deficient clearance of infected cells in the mice was potentially due to the lower levels of CD8+ T cells, which are associated with COVID-19 mortality in humans. Taken together, these results indicate that the pathology of SARS-CoV-2 infection in K18-hACE2 mice mimics severe COVID-19 in humans.COVID-19 pathology is highly variable in humans, and the mechanism behind this variability needs to be thoroughly explored to optimise prognosis and treatment. Direct comparison of these two integral disease models not only informs future research using animal models of COVID-19, but also provides comprehensive insights into variation in COVID-19 pathology." @default.
• W4308805156 created "2022-11-15" @default.
• W4308805156 creator A5034143634 @default.
• W4308805156 date "2022-11-01" @default.
• W4308805156 modified "2023-09-26" @default.
• W4308805156 title "COVID-19's next top model" @default.
• W4308805156 cites W4304687521 @default.
• W4308805156 doi "https://doi.org/10.1242/dmm.049972" @default.
• W4308805156 hasPublicationYear "2022" @default.
• W4308805156 type Work @default.
• W4308805156 citedByCount "0" @default.
• W4308805156 crossrefType "journal-article" @default.
• W4308805156 hasAuthorship W4308805156A5034143634 @default.
• W4308805156 hasBestOaLocation W43088051561 @default.
• W4308805156 hasConcept C142724271 @default.
• W4308805156 hasConcept C153911025 @default.
• W4308805156 hasConcept C159047783 @default.
• W4308805156 hasConcept C159985019 @default.
• W4308805156 hasConcept C167672396 @default.
• W4308805156 hasConcept C192562407 @default.
• W4308805156 hasConcept C203014093 @default.
• W4308805156 hasConcept C2778362869 @default.
• W4308805156 hasConcept C2778575167 @default.
• W4308805156 hasConcept C2779134260 @default.
• W4308805156 hasConcept C2779525107 @default.
• W4308805156 hasConcept C2780502288 @default.
• W4308805156 hasConcept C2780942790 @default.
• W4308805156 hasConcept C3008058167 @default.
• W4308805156 hasConcept C30407753 @default.
• W4308805156 hasConcept C42407357 @default.
• W4308805156 hasConcept C524204448 @default.
• W4308805156 hasConcept C71924100 @default.
• W4308805156 hasConcept C86803240 @default.
• W4308805156 hasConcept C8891405 @default.
• W4308805156 hasConcept C89623803 @default.
• W4308805156 hasConceptScore W4308805156C142724271 @default.
• W4308805156 hasConceptScore W4308805156C153911025 @default.
• W4308805156 hasConceptScore W4308805156C159047783 @default.
• W4308805156 hasConceptScore W4308805156C159985019 @default.
• W4308805156 hasConceptScore W4308805156C167672396 @default.
• W4308805156 hasConceptScore W4308805156C192562407 @default.
• W4308805156 hasConceptScore W4308805156C203014093 @default.
• W4308805156 hasConceptScore W4308805156C2778362869 @default.
• W4308805156 hasConceptScore W4308805156C2778575167 @default.
• W4308805156 hasConceptScore W4308805156C2779134260 @default.
• W4308805156 hasConceptScore W4308805156C2779525107 @default.
• W4308805156 hasConceptScore W4308805156C2780502288 @default.
• W4308805156 hasConceptScore W4308805156C2780942790 @default.
• W4308805156 hasConceptScore W4308805156C3008058167 @default.
• W4308805156 hasConceptScore W4308805156C30407753 @default.
• W4308805156 hasConceptScore W4308805156C42407357 @default.
• W4308805156 hasConceptScore W4308805156C524204448 @default.
• W4308805156 hasConceptScore W4308805156C71924100 @default.
• W4308805156 hasConceptScore W4308805156C86803240 @default.
• W4308805156 hasConceptScore W4308805156C8891405 @default.
• W4308805156 hasConceptScore W4308805156C89623803 @default.
• W4308805156 hasIssue "11" @default.
• W4308805156 hasLocation W43088051561 @default.
• W4308805156 hasOpenAccess W4308805156 @default.
• W4308805156 hasPrimaryLocation W43088051561 @default.
• W4308805156 hasRelatedWork W1971459544 @default.
• W4308805156 hasRelatedWork W2003252805 @default.
• W4308805156 hasRelatedWork W2015049439 @default.
• W4308805156 hasRelatedWork W2058438678 @default.
• W4308805156 hasRelatedWork W2124546424 @default.
• W4308805156 hasRelatedWork W2185202032 @default.
• W4308805156 hasRelatedWork W2341165765 @default.
• W4308805156 hasRelatedWork W2416887118 @default.
• W4308805156 hasRelatedWork W2800437047 @default.
• W4308805156 hasRelatedWork W87483936 @default.
• W4308805156 hasVolume "15" @default.
• W4308805156 isParatext "false" @default.
• W4308805156 isRetracted "false" @default.
• W4308805156 workType "article" @default.