Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308806571> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W4308806571 endingPage "60" @default.
- W4308806571 startingPage "59" @default.
- W4308806571 abstract "The skin and especially the stratum corneum (SC) act as a barrier and protect epidermal cells and thus the whole body against xenobiotica of the external environment. Topical skin treatment requires an efficient drug delivery system (DDS). Polymer-based nanocarriers represent novel transport vehicles for dermal application of drugs. In this study dendritic core-multishell (CMS) nanoparticles were investigated as promising candidates. CMS nanoparticles were loaded with a drug (analogue) and were applied to penetration studies of skin. We determined by dual-frequency electron paramagnetic resonance (EPR) how dexamethasone (Dx) labelled with 3-carboxy-2,2,5,5-tetramethyl-1-pyrrolidinyloxy (PCA) is associated with the CMS. The micro-environment of the drug loaded to CMS nanoparticles was investigated by pulsed high-field EPR at cryogenic temperature, making use of the fact that magnetic parameters (g-, A-matrices, and spin-lattice relaxation time) represent specific probes for the micro-environment. Additionally, the rotational correlation time of spin-labelled Dx was probed by continuous wave EPR at ambient temperature, which provides independent information on the drug environment. Furthermore, the penetration depth of Dx into the stratum corneum of porcine skin after different topical applications was investigated. The location of Dx in the CMS nanoparticles is revealed and the function of CMS as penetration enhancers for topical application is shown." @default.
- W4308806571 created "2022-11-15" @default.
- W4308806571 creator A5006197608 @default.
- W4308806571 creator A5007756581 @default.
- W4308806571 creator A5030732348 @default.
- W4308806571 creator A5030751359 @default.
- W4308806571 creator A5045218797 @default.
- W4308806571 creator A5066357476 @default.
- W4308806571 creator A5067410358 @default.
- W4308806571 creator A5074068009 @default.
- W4308806571 creator A5086468930 @default.
- W4308806571 creator A5091147372 @default.
- W4308806571 date "2022-11-01" @default.
- W4308806571 modified "2023-10-15" @default.
- W4308806571 title "Use of Electron Paramagnetic Resonance (EPR) in vivo to evaluate redox status in a preclinical model of acute lung injury" @default.
- W4308806571 doi "https://doi.org/10.1016/j.freeradbiomed.2022.10.097" @default.
- W4308806571 hasPublicationYear "2022" @default.
- W4308806571 type Work @default.
- W4308806571 citedByCount "0" @default.
- W4308806571 crossrefType "journal-article" @default.
- W4308806571 hasAuthorship W4308806571A5006197608 @default.
- W4308806571 hasAuthorship W4308806571A5007756581 @default.
- W4308806571 hasAuthorship W4308806571A5030732348 @default.
- W4308806571 hasAuthorship W4308806571A5030751359 @default.
- W4308806571 hasAuthorship W4308806571A5045218797 @default.
- W4308806571 hasAuthorship W4308806571A5066357476 @default.
- W4308806571 hasAuthorship W4308806571A5067410358 @default.
- W4308806571 hasAuthorship W4308806571A5074068009 @default.
- W4308806571 hasAuthorship W4308806571A5086468930 @default.
- W4308806571 hasAuthorship W4308806571A5091147372 @default.
- W4308806571 hasConcept C121332964 @default.
- W4308806571 hasConcept C12554922 @default.
- W4308806571 hasConcept C127413603 @default.
- W4308806571 hasConcept C136229726 @default.
- W4308806571 hasConcept C142724271 @default.
- W4308806571 hasConcept C150903083 @default.
- W4308806571 hasConcept C155672457 @default.
- W4308806571 hasConcept C171250308 @default.
- W4308806571 hasConcept C177462420 @default.
- W4308806571 hasConcept C18150654 @default.
- W4308806571 hasConcept C185592680 @default.
- W4308806571 hasConcept C187961010 @default.
- W4308806571 hasConcept C192562407 @default.
- W4308806571 hasConcept C207001950 @default.
- W4308806571 hasConcept C2778370115 @default.
- W4308806571 hasConcept C2778639546 @default.
- W4308806571 hasConcept C2779820397 @default.
- W4308806571 hasConcept C42475967 @default.
- W4308806571 hasConcept C46141821 @default.
- W4308806571 hasConcept C71924100 @default.
- W4308806571 hasConcept C80107235 @default.
- W4308806571 hasConcept C86803240 @default.
- W4308806571 hasConceptScore W4308806571C121332964 @default.
- W4308806571 hasConceptScore W4308806571C12554922 @default.
- W4308806571 hasConceptScore W4308806571C127413603 @default.
- W4308806571 hasConceptScore W4308806571C136229726 @default.
- W4308806571 hasConceptScore W4308806571C142724271 @default.
- W4308806571 hasConceptScore W4308806571C150903083 @default.
- W4308806571 hasConceptScore W4308806571C155672457 @default.
- W4308806571 hasConceptScore W4308806571C171250308 @default.
- W4308806571 hasConceptScore W4308806571C177462420 @default.
- W4308806571 hasConceptScore W4308806571C18150654 @default.
- W4308806571 hasConceptScore W4308806571C185592680 @default.
- W4308806571 hasConceptScore W4308806571C187961010 @default.
- W4308806571 hasConceptScore W4308806571C192562407 @default.
- W4308806571 hasConceptScore W4308806571C207001950 @default.
- W4308806571 hasConceptScore W4308806571C2778370115 @default.
- W4308806571 hasConceptScore W4308806571C2778639546 @default.
- W4308806571 hasConceptScore W4308806571C2779820397 @default.
- W4308806571 hasConceptScore W4308806571C42475967 @default.
- W4308806571 hasConceptScore W4308806571C46141821 @default.
- W4308806571 hasConceptScore W4308806571C71924100 @default.
- W4308806571 hasConceptScore W4308806571C80107235 @default.
- W4308806571 hasConceptScore W4308806571C86803240 @default.
- W4308806571 hasLocation W43088065711 @default.
- W4308806571 hasOpenAccess W4308806571 @default.
- W4308806571 hasPrimaryLocation W43088065711 @default.
- W4308806571 hasRelatedWork W1595862141 @default.
- W4308806571 hasRelatedWork W1968179860 @default.
- W4308806571 hasRelatedWork W2019102553 @default.
- W4308806571 hasRelatedWork W2023624408 @default.
- W4308806571 hasRelatedWork W2079489167 @default.
- W4308806571 hasRelatedWork W2538746730 @default.
- W4308806571 hasRelatedWork W2571220287 @default.
- W4308806571 hasRelatedWork W2980574643 @default.
- W4308806571 hasRelatedWork W3006014150 @default.
- W4308806571 hasRelatedWork W3197500709 @default.
- W4308806571 hasVolume "192" @default.
- W4308806571 isParatext "false" @default.
- W4308806571 isRetracted "false" @default.
- W4308806571 workType "article" @default.