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- W4308808839 abstract "Replication stress is a prominent hallmark of tumor cells, which is crucial for maintaining genomic integrity. However, it remains poorly understood whether replication stress can serve as a surrogate biomarker to indicate prognosis and treatment response of pancreatic cancer.Transcriptomic and clinical data were obtained from The Cancer Genome Atlas and literature. An integrated signature of 18 replication-stress associated genes (termed as REST18) was established using the cox proportional hazards regression analysis. Tumors were sorted into REST18-low and REST18-high groups. Survival analysis, gene set enrichment analysis and composition of immune cells were compared between these tumors.Patients with REST18-high tumors showed worse prognoses than those with REST18-low tumors in the TCGA database and the finding is validated in an independent cohort of pancreatic cancer. Comparison of REST18 model and other molecular classifications showed that REST18-high tumors are positively correlated to basal-like or squamous phenotypes, which have higher metastasis potential. DNA repair pathway is enriched in the REST18-high tumors. Analysis of tumor immune microenvironment found that REST18-high tumors are characterized with “immune-cold” features. Univariate and multivariate analysis show that REST18 is an independent risk factor for overall survival and predicts outcomes of chemotherapy in pancreatic cancer.REST18 is a novel biomarker to indicate prognosis and treatment response of chemotherapy in pancreatic cancer." @default.
- W4308808839 created "2022-11-15" @default.
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- W4308808839 date "2023-01-01" @default.
- W4308808839 modified "2023-09-26" @default.
- W4308808839 title "Insulin based treatment or blood purification for hypertriglyceridaemia-associated acute pancreatitis: Our reply" @default.
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- W4308808839 doi "https://doi.org/10.1016/j.pan.2022.11.002" @default.
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