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- W4308809917 abstract "Prodromal Parkinson’s disease (PD) is a clinicopathological concept whereby symptoms relatable to PD, together with ongoing degenerative process, are present, but in absence of motor symptoms that allow the clinical diagnosis. Its recognition in the general population is difficult because of the nonspecificity of its clinical manifestations, and for the current lack of reliable biomarkers to identify, and track the condition over time up to the conversion to clinical PD. Molecular imaging using positron emission tomography (PET) and single photon emission computerized tomography (SPECT) use radiotracers that bind with high affinity to their molecules of interest and allow the quantification of their density, or function, in vivo at a molecular level. Several radiotracers have been employed in prodromal PD research to investigate early markers of degeneration of dopaminergic or nondopaminergic neurotransmitter pathways, and to assess their relationship with the clinical progression and the conversion to clinical PD. PET and SPECT imaging has also been used in nonmotor carriers of genetic mutations for autosomal dominant forms of familial Parkinsonism, in the attempt to recapitulate, in these subjects, the biological alterations preceding the phenoconversion to PD. This chapter will illustrate the recent advances from molecular imaging research in cohorts representative of prodromal PD." @default.
- W4308809917 created "2022-11-16" @default.
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- W4308809917 creator A5015136173 @default.
- W4308809917 creator A5021635450 @default.
- W4308809917 creator A5046742969 @default.
- W4308809917 date "2023-01-01" @default.
- W4308809917 modified "2023-09-23" @default.
- W4308809917 title "Molecular imaging in prodromal Parkinson’s disease" @default.
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