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- W4308809984 abstract "Lewy body dementias are the second most common form of dementia after Alzheimer's disease and are clinically characterized by cognitive decline, visual hallucinations, bradykinesia, and fluctuations of the motor and cognitive functions. The temporal onset and the degree of cognitive impairment are key for the clinical differentiation among Parkinson's disease with mild cognitive impairment (PD-MCI), Parkinson's disease dementia (PDD), and dementia with Lewy Bodies (DLB), yet neuropathologically, they are all characterized by the accumulation of aggregated α-synuclein in the presence of Lewy bodies and Lewy neurites in postmortem brain sections. Despite their high prevalence, the pathophysiology of Lewy body dementias is still largely unknown. Noninvasive neuroimaging techniques such as magnetic resonance imaging (MRI) have a unique potential to provide compelling window into structural, microstructural, and functional alterations of the brain in vivo, with an outstanding spatial and ample temporal resolution. PD-MCI, PDD, and DLB have been the object of intense research using MRI with the purpose of improving the diagnosis, detecting anatomical and functional alterations and their relationship with disease severity and duration. This chapter reviews the main findings obtained from MRI neuroimaging research studies in people living with Lewy body dementias." @default.
- W4308809984 created "2022-11-16" @default.
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- W4308809984 date "2023-01-01" @default.
- W4308809984 modified "2023-09-23" @default.
- W4308809984 title "Magnetic resonance imaging in Parkinson's disease with mild cognitive impairment, Parkinson's disease dementia, and dementia with Lewy bodies" @default.
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- W4308809984 doi "https://doi.org/10.1016/b978-0-12-821651-4.00021-x" @default.
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