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- W4308809995 abstract "Subcellular organization for the separation of biochemical processes is critically important for facilitating and maintaining cell functions. Membrane-less organelles (MLOs), subcellular structures that are formed by biomolecular interactions that drive liquid–liquid phase separation, are dense phases highly concentrated in proteins and nucleic acids that include or exclude a specific subset of biomolecules and metabolites. The structural properties inherent to the macromolecule(s) that participate in MLO formation determine the organization and structure of the dense phase by modulating the liquid to solid transition of the condensate. Furthermore, the interactions between the constituent members of the condensate define the organization of the structure and determine the properties and liquidness of the outer and inner layers influencing the overall function and stability of the MLO. Therefore, it is important to understand the interplay of the properties of proteins and nucleic acids that contribute to the diversity of MLOs organization." @default.
- W4308809995 created "2022-11-16" @default.
- W4308809995 creator A5001432346 @default.
- W4308809995 creator A5045110014 @default.
- W4308809995 date "2023-01-01" @default.
- W4308809995 modified "2023-09-23" @default.
- W4308809995 title "Major structural features of membrane-less organelles" @default.
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- W4308809995 doi "https://doi.org/10.1016/b978-0-12-823967-4.00008-7" @default.
- W4308809995 hasPublicationYear "2023" @default.
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