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• W4308810010 endingPage "504" @default.
• W4308810010 startingPage "485" @default.
• W4308810010 abstract "Cell fitness, i.e., the ability of a cell to persevere under specific conditions, represents an important factor driving cell competition, which, in its turn, is at the roots of numerous biological processes, including aging. These biological phenomena encompass a multitude of extremely complex and highly intertwined processes and pathways and are undoubtedly crucial for the maintenance of life. This chapter represents several illustrative examples showing the importance of liquid–liquid phase separation and resulting membrane-less organelles (MLOs) and biomolecular condensates in regulation of cell fitness, cell competition, and aging/senescence. It also introduces a concept of MLOstasis (MLO homeostasis), which represents a multitude of cellular pathways and processes defining and controlling the fate of and interplay between the multiple MLOs and also includes pathways and processes via which MLOs affect and regulate cellular fitness." @default.
• W4308810010 created "2022-11-16" @default.
• W4308810010 creator A5083199032 @default.
• W4308810010 date "2023-01-01" @default.
• W4308810010 modified "2023-09-26" @default.
• W4308810010 title "MLOstasis: liquid–liquid phase separation and biomolecular condensates in cell competition, fitness, and aging" @default.
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