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- W4308835214 abstract "Abstract In vertebrates, the embryonic olfactory epithelium contains progenitors that will give rise to distinct classes of neurons, including olfactory sensory neurons (OSN, involved in odor detection), vomeronasal sensory neurons (VSN, responsible for pheromone sensing) and GnRH neurons that control the hypothalamic-pituitary-gonadal axis. Currently, these three neuronal lineages are usually believed to emerge from uniform pools of progenitors. Here we found that the homeodomain transcription factor Dbx1 is expressed by neurogenic progenitors in the developing and adult mouse olfactory epithelium. We demonstrate that Dbx1 itself is dispensable for neuronal fate specification and global organization of the olfactory sensory system. Using lineage tracing we characterize the contribution of Dbx1 lineages to OSN, VSN and GnRH neuron populations and reveal an unexpected degree of diversity. Furthermore, we demonstrate that Dbx1 -expressing progenitors remain neurogenic in the absence of the proneural gene Ascl1 . Our work therefore points to the existence of distinct neurogenic programs in Dbx1-derived and other olfactory lineages." @default.
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- W4308835214 date "2022-11-12" @default.
- W4308835214 modified "2023-10-18" @default.
- W4308835214 title "Diversity within olfactory sensory derivatives revealed by the contribution of Dbx1 lineages" @default.
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- W4308835214 doi "https://doi.org/10.1101/2022.11.12.514524" @default.
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