Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308840104> ?p ?o ?g. }
- W4308840104 abstract "Summary Helminth endemic regions report lower COVID-19 morbidity and mortality. Here, we show that lung remodeling from a prior infection with a lung migrating helminth, Nippostrongylus brasiliensis , enhances viral clearance and survival of human-ACE2 transgenic mice challenged with SARS-CoV-2 (SCV2). This protection is associated with a lymphocytic infiltrate including an increased accumulation of pulmonary SCV2-specific CD8+ T cells and anti-CD8 antibody depletion abrogated the N. brasiliensis -mediated reduction in viral loads. Pulmonary macrophages with a type-2 transcriptional signature persist in the lungs of N. brasiliensis exposed mice after clearance of the parasite and establish a primed environment for increased antigen presentation. Accordingly, depletion of macrophages ablated the augmented viral clearance and accumulation of CD8+ T cells driven by prior N. brasiliensis infection. Together, these findings support the concept that lung migrating helminths can limit disease severity during SCV2 infection through macrophage-dependent enhancement of anti-viral CD8+ T cell responses. Abstract Figure" @default.
- W4308840104 created "2022-11-17" @default.
- W4308840104 creator A5013067271 @default.
- W4308840104 creator A5016487212 @default.
- W4308840104 creator A5018592318 @default.
- W4308840104 creator A5018643974 @default.
- W4308840104 creator A5023730743 @default.
- W4308840104 creator A5044863582 @default.
- W4308840104 creator A5052332035 @default.
- W4308840104 creator A5069625663 @default.
- W4308840104 creator A5076314549 @default.
- W4308840104 creator A5077162460 @default.
- W4308840104 creator A5079932633 @default.
- W4308840104 creator A5090735591 @default.
- W4308840104 date "2022-11-10" @default.
- W4308840104 modified "2023-10-12" @default.
- W4308840104 title "Helminth exposure protects against murine SARS-CoV-2 infection through macrophage dependent T cell activation" @default.
- W4308840104 cites W1609125121 @default.
- W4308840104 cites W1653545152 @default.
- W4308840104 cites W1764616085 @default.
- W4308840104 cites W1984198270 @default.
- W4308840104 cites W1985859986 @default.
- W4308840104 cites W1997942715 @default.
- W4308840104 cites W2011671647 @default.
- W4308840104 cites W2020437257 @default.
- W4308840104 cites W2024524568 @default.
- W4308840104 cites W2037123168 @default.
- W4308840104 cites W2038689279 @default.
- W4308840104 cites W2044769078 @default.
- W4308840104 cites W2047971723 @default.
- W4308840104 cites W2062767382 @default.
- W4308840104 cites W2064756683 @default.
- W4308840104 cites W2064898767 @default.
- W4308840104 cites W2069061376 @default.
- W4308840104 cites W2071022240 @default.
- W4308840104 cites W2086331830 @default.
- W4308840104 cites W2088102919 @default.
- W4308840104 cites W2098216175 @default.
- W4308840104 cites W2098699177 @default.
- W4308840104 cites W2100866502 @default.
- W4308840104 cites W2103017472 @default.
- W4308840104 cites W2122609753 @default.
- W4308840104 cites W2124700037 @default.
- W4308840104 cites W2129741568 @default.
- W4308840104 cites W2131103018 @default.
- W4308840104 cites W2132644211 @default.
- W4308840104 cites W2139712080 @default.
- W4308840104 cites W2141185994 @default.
- W4308840104 cites W2141897776 @default.
- W4308840104 cites W2161656138 @default.
- W4308840104 cites W2162196121 @default.
- W4308840104 cites W2167820901 @default.
- W4308840104 cites W2168632939 @default.
- W4308840104 cites W2170720146 @default.
- W4308840104 cites W2301044272 @default.
- W4308840104 cites W2317445622 @default.
- W4308840104 cites W2467677013 @default.
- W4308840104 cites W2485004164 @default.
- W4308840104 cites W2587192575 @default.
- W4308840104 cites W2606914311 @default.
- W4308840104 cites W2780282321 @default.
- W4308840104 cites W2789367247 @default.
- W4308840104 cites W2794480084 @default.
- W4308840104 cites W2886518661 @default.
- W4308840104 cites W2887880586 @default.
- W4308840104 cites W2898560906 @default.
- W4308840104 cites W2907514116 @default.
- W4308840104 cites W2927199411 @default.
- W4308840104 cites W2945953423 @default.
- W4308840104 cites W2946173685 @default.
- W4308840104 cites W3001195213 @default.
- W4308840104 cites W3014928149 @default.
- W4308840104 cites W3023191165 @default.
- W4308840104 cites W3026265675 @default.
- W4308840104 cites W3028596600 @default.
- W4308840104 cites W3031410383 @default.
- W4308840104 cites W3043831218 @default.
- W4308840104 cites W3049200577 @default.
- W4308840104 cites W3080378920 @default.
- W4308840104 cites W3080981445 @default.
- W4308840104 cites W3084879098 @default.
- W4308840104 cites W3090085167 @default.
- W4308840104 cites W3099347064 @default.
- W4308840104 cites W3112600195 @default.
- W4308840104 cites W3120168938 @default.
- W4308840104 cites W3121177038 @default.
- W4308840104 cites W3133141459 @default.
- W4308840104 cites W3155964721 @default.
- W4308840104 cites W3173905692 @default.
- W4308840104 cites W3191489145 @default.
- W4308840104 cites W3194246131 @default.
- W4308840104 cites W3197127917 @default.
- W4308840104 cites W3210938634 @default.
- W4308840104 cites W3216410461 @default.
- W4308840104 cites W4205184674 @default.
- W4308840104 cites W4205659783 @default.
- W4308840104 cites W4205814082 @default.
- W4308840104 cites W4220928107 @default.
- W4308840104 cites W4220966209 @default.
- W4308840104 cites W4226479288 @default.