Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308840292> ?p ?o ?g. }
- W4308840292 abstract "ABSTRACT There is growing interest in the beneficial effects of immune system boosting through the administration of adjuvants, not only in acute infections such as COVID but also in chronic degenerative disorders that are potentially associated with infection. The best-known immunopotentiators are Freund’s complete adjuvant (FCA) and its relative Bacille Calmete–Guérin (BCG), both based on Mycobacterium species. The key pathogen-associated molecular patterns (PAMPs) in both FCA and BCG are muramyl dipeptides (MDPs and glucosaminyl-MDP, GMDP). We previously identified the evolutionarily conserved protein Y-box factor YB-1/YBX1 as a primary target for MDP/GMDP. Unlike other host receptors for PAMPs, YB-1 is a diffusible molecule, and we therefore explored whether in vivo administration of YB-1, rather than its PAMP ligands, might enhance the immune response to a bacterial antigen and/or influence survival in the face of bacterial infection. We report that mice receiving YB-1 plus GMDP in vivo mount a significantly increased B cell response versus GMDP alone against a test antigen ( Yersinia pestis V antigen), and that YB-1 administration alone significantly promotes survival in the face of lethal bacterial ( Escherichia coli ) challenge in vivo . Independent confirmation is warranted because recombinant YB-1 and its ligands could hold great promise both as adjuvants and as therapeutics." @default.
- W4308840292 created "2022-11-17" @default.
- W4308840292 creator A5001065132 @default.
- W4308840292 creator A5002665222 @default.
- W4308840292 creator A5009103621 @default.
- W4308840292 creator A5013883312 @default.
- W4308840292 creator A5015129035 @default.
- W4308840292 creator A5023868733 @default.
- W4308840292 creator A5048060054 @default.
- W4308840292 creator A5054293283 @default.
- W4308840292 creator A5077177127 @default.
- W4308840292 creator A5078481470 @default.
- W4308840292 date "2022-11-10" @default.
- W4308840292 modified "2023-10-16" @default.
- W4308840292 title "Adjuvant effects of multifunctional transcription factor and BCG target YB-1: exogenous YB-1 enhances specific antibody production<i>in vivo</i>and protects mice against lethal<i>E. coli</i>challenge" @default.
- W4308840292 cites W1780174959 @default.
- W4308840292 cites W1895463703 @default.
- W4308840292 cites W1966117251 @default.
- W4308840292 cites W1969081810 @default.
- W4308840292 cites W1980009004 @default.
- W4308840292 cites W1987920460 @default.
- W4308840292 cites W1999971302 @default.
- W4308840292 cites W2000992025 @default.
- W4308840292 cites W2001166572 @default.
- W4308840292 cites W2001888236 @default.
- W4308840292 cites W2010318115 @default.
- W4308840292 cites W2011722730 @default.
- W4308840292 cites W2030000698 @default.
- W4308840292 cites W2037896557 @default.
- W4308840292 cites W2043865646 @default.
- W4308840292 cites W2065982624 @default.
- W4308840292 cites W2070475814 @default.
- W4308840292 cites W2074065268 @default.
- W4308840292 cites W2081149451 @default.
- W4308840292 cites W2083556305 @default.
- W4308840292 cites W2086506975 @default.
- W4308840292 cites W2090520729 @default.
- W4308840292 cites W2141701614 @default.
- W4308840292 cites W2144448602 @default.
- W4308840292 cites W2163847018 @default.
- W4308840292 cites W2213182226 @default.
- W4308840292 cites W2294532941 @default.
- W4308840292 cites W2311396780 @default.
- W4308840292 cites W2322039271 @default.
- W4308840292 cites W2524572457 @default.
- W4308840292 cites W2783642412 @default.
- W4308840292 cites W2901746667 @default.
- W4308840292 cites W2902546561 @default.
- W4308840292 cites W2915653092 @default.
- W4308840292 cites W2916861400 @default.
- W4308840292 cites W2943762716 @default.
- W4308840292 cites W2951492607 @default.
- W4308840292 cites W2983671769 @default.
- W4308840292 cites W3032007913 @default.
- W4308840292 cites W3041881467 @default.
- W4308840292 cites W3046783592 @default.
- W4308840292 cites W3081629575 @default.
- W4308840292 cites W3132706571 @default.
- W4308840292 cites W3144140615 @default.
- W4308840292 cites W3154084155 @default.
- W4308840292 cites W3162621824 @default.
- W4308840292 cites W3172091771 @default.
- W4308840292 cites W3193791242 @default.
- W4308840292 cites W3195834805 @default.
- W4308840292 cites W3210602851 @default.
- W4308840292 cites W3210758353 @default.
- W4308840292 cites W3213927670 @default.
- W4308840292 cites W4220928107 @default.
- W4308840292 cites W4237269238 @default.
- W4308840292 cites W748993927 @default.
- W4308840292 doi "https://doi.org/10.1101/2022.11.09.515841" @default.
- W4308840292 hasPublicationYear "2022" @default.
- W4308840292 type Work @default.
- W4308840292 citedByCount "1" @default.
- W4308840292 countsByYear W43088402922023 @default.
- W4308840292 crossrefType "posted-content" @default.
- W4308840292 hasAuthorship W4308840292A5001065132 @default.
- W4308840292 hasAuthorship W4308840292A5002665222 @default.
- W4308840292 hasAuthorship W4308840292A5009103621 @default.
- W4308840292 hasAuthorship W4308840292A5013883312 @default.
- W4308840292 hasAuthorship W4308840292A5015129035 @default.
- W4308840292 hasAuthorship W4308840292A5023868733 @default.
- W4308840292 hasAuthorship W4308840292A5048060054 @default.
- W4308840292 hasAuthorship W4308840292A5054293283 @default.
- W4308840292 hasAuthorship W4308840292A5077177127 @default.
- W4308840292 hasAuthorship W4308840292A5078481470 @default.
- W4308840292 hasBestOaLocation W43088402921 @default.
- W4308840292 hasConcept C104317684 @default.
- W4308840292 hasConcept C147483822 @default.
- W4308840292 hasConcept C150903083 @default.
- W4308840292 hasConcept C159654299 @default.
- W4308840292 hasConcept C203014093 @default.
- W4308840292 hasConcept C207001950 @default.
- W4308840292 hasConcept C2776444769 @default.
- W4308840292 hasConcept C2777701055 @default.
- W4308840292 hasConcept C2777863537 @default.
- W4308840292 hasConcept C2778222588 @default.
- W4308840292 hasConcept C502942594 @default.
- W4308840292 hasConcept C547475151 @default.
- W4308840292 hasConcept C55493867 @default.