Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308843646> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W4308843646 abstract "Abstract Objective To explore the genetic characteristics of systemic juvenile rheumatoid arthritis (sJIA) and type 1 diabetes mellitus (T1D). Methods The microarray data of sJIA and T1D from Gene Expression Omnibus (GEO) were analyzed. The shared differentially expressed genes (SDEGs) were identified by the GEO2R tool, and genes of extracellular proteins were identified. Then, weighted gene co-expression network analysis (WGCNA) was used to identify the shared immune-related genes (IRGs) that are associated with pJIA and T1D. In addition, transcription factors (TFs) and their target genes in SDEGs were obtained by comparing databases from HumanTFDB, ENCODE, JASPAR, and TRRUST. Finally, functional enrichment analyses of the previously identified gene sets were performed by g: Profiler. Results We found 285 up-regulated and 97 down-regulated SDEGs via GEO2R, and by constructing a TFs-targeted SDEGs network, 5 key TFs (KLF9, ARID3A, ZNF639, NEF2, MYB) were screened. Functional enrichment analyses of SDEGs, IRGs, and TFs-targeted SDEGs suggested the important role of the innate immune system, JAK-STAT and Ras-MAPK-ERK signaling pathways in the pathogenesis of sJIA and T1D, involving biological processes such as neutrophils and mononuclear cells, phosphorylation, transcellular signaling, and transferase activity, etc. Conclusion Innate immune abnormalities play important roles in sJIA and T1D, and the JAK-STAT and Ras-MAPK-ERK pathways, which are closely related to inflammation and immune regulation, may be involved. The regulatory roles of KLF9, ARID3A, ZNF639, NEF2, and MYB in this network need to be further investigated." @default.
- W4308843646 created "2022-11-17" @default.
- W4308843646 creator A5029316081 @default.
- W4308843646 creator A5075141324 @default.
- W4308843646 date "2022-11-11" @default.
- W4308843646 modified "2023-10-18" @default.
- W4308843646 title "Exploration of Common Genomic Signatures of Systemic Juvenile Rheumatoid Arthritis and Type 1 Diabetes" @default.
- W4308843646 cites W1544691147 @default.
- W4308843646 cites W1966327575 @default.
- W4308843646 cites W1984959662 @default.
- W4308843646 cites W2007009134 @default.
- W4308843646 cites W2041578282 @default.
- W4308843646 cites W2052047252 @default.
- W4308843646 cites W2079796046 @default.
- W4308843646 cites W2105278820 @default.
- W4308843646 cites W2125873412 @default.
- W4308843646 cites W2144090251 @default.
- W4308843646 cites W2155473135 @default.
- W4308843646 cites W2258464106 @default.
- W4308843646 cites W2299835434 @default.
- W4308843646 cites W2516617960 @default.
- W4308843646 cites W2585546483 @default.
- W4308843646 cites W2607305951 @default.
- W4308843646 cites W2612000982 @default.
- W4308843646 cites W2621904819 @default.
- W4308843646 cites W2771356808 @default.
- W4308843646 cites W2782454362 @default.
- W4308843646 cites W2782494600 @default.
- W4308843646 cites W2792468812 @default.
- W4308843646 cites W2793818228 @default.
- W4308843646 cites W2891678790 @default.
- W4308843646 cites W2895111641 @default.
- W4308843646 cites W2903514011 @default.
- W4308843646 cites W2942157380 @default.
- W4308843646 cites W2944545583 @default.
- W4308843646 cites W2976534241 @default.
- W4308843646 cites W2997598616 @default.
- W4308843646 cites W3033722005 @default.
- W4308843646 cites W3040651070 @default.
- W4308843646 cites W3090579245 @default.
- W4308843646 cites W3107820052 @default.
- W4308843646 cites W3170381768 @default.
- W4308843646 cites W3181403989 @default.
- W4308843646 cites W3187366210 @default.
- W4308843646 cites W3188371230 @default.
- W4308843646 cites W3197143241 @default.
- W4308843646 cites W3215596355 @default.
- W4308843646 cites W4284711288 @default.
- W4308843646 doi "https://doi.org/10.21203/rs.3.rs-2249432/v1" @default.
- W4308843646 hasPublicationYear "2022" @default.
- W4308843646 type Work @default.
- W4308843646 citedByCount "0" @default.
- W4308843646 crossrefType "posted-content" @default.
- W4308843646 hasAuthorship W4308843646A5029316081 @default.
- W4308843646 hasAuthorship W4308843646A5075141324 @default.
- W4308843646 hasBestOaLocation W43088436461 @default.
- W4308843646 hasConcept C104317684 @default.
- W4308843646 hasConcept C136449434 @default.
- W4308843646 hasConcept C203014093 @default.
- W4308843646 hasConcept C502942594 @default.
- W4308843646 hasConcept C54355233 @default.
- W4308843646 hasConcept C57074206 @default.
- W4308843646 hasConcept C62478195 @default.
- W4308843646 hasConcept C70721500 @default.
- W4308843646 hasConcept C86339819 @default.
- W4308843646 hasConcept C86803240 @default.
- W4308843646 hasConcept C8891405 @default.
- W4308843646 hasConceptScore W4308843646C104317684 @default.
- W4308843646 hasConceptScore W4308843646C136449434 @default.
- W4308843646 hasConceptScore W4308843646C203014093 @default.
- W4308843646 hasConceptScore W4308843646C502942594 @default.
- W4308843646 hasConceptScore W4308843646C54355233 @default.
- W4308843646 hasConceptScore W4308843646C57074206 @default.
- W4308843646 hasConceptScore W4308843646C62478195 @default.
- W4308843646 hasConceptScore W4308843646C70721500 @default.
- W4308843646 hasConceptScore W4308843646C86339819 @default.
- W4308843646 hasConceptScore W4308843646C86803240 @default.
- W4308843646 hasConceptScore W4308843646C8891405 @default.
- W4308843646 hasLocation W43088436461 @default.
- W4308843646 hasOpenAccess W4308843646 @default.
- W4308843646 hasPrimaryLocation W43088436461 @default.
- W4308843646 hasRelatedWork W1524155111 @default.
- W4308843646 hasRelatedWork W1556307916 @default.
- W4308843646 hasRelatedWork W1557621914 @default.
- W4308843646 hasRelatedWork W1980618878 @default.
- W4308843646 hasRelatedWork W2048363111 @default.
- W4308843646 hasRelatedWork W2103515427 @default.
- W4308843646 hasRelatedWork W2141330728 @default.
- W4308843646 hasRelatedWork W2144926920 @default.
- W4308843646 hasRelatedWork W2946615038 @default.
- W4308843646 hasRelatedWork W4315797293 @default.
- W4308843646 isParatext "false" @default.
- W4308843646 isRetracted "false" @default.
- W4308843646 workType "article" @default.