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- W4308870591 abstract "Stroke is primarily a neurodegenerative disease but can also severely impact the functions of other vital organs and deteriorate disease outcomes. A malfunction of the gastrointestinal tract (GIT), commonly observed in stroke patients, is often characterized by severe bowel obstruction, intestinal microbiota changes and inflammation. Over-activated immune cells after stroke are the major contributors to endorse intestinal inflammation and may induce damage to single-layer epithelial cell barriers. The post-stroke leakage of intestinal barriers may allow the translocation and dissemination of resident microflora to systemic organs and cause sepsis. This overshooting systemic immune reaction fuels ongoing inflammation in the degenerating brain and slows recovery. Currently, the therapeutic options to treat these GIT-associated anomalies are very limited and further research is required to develop novel treatments. In this mini-review, we first discuss the current knowledge from clinical studies and experimental stroke models that provide strong evidence of the existence of post-stroke GIT complications. Then, we review the literature regarding novel therapeutic approaches that might help to maintain GIT homeostasis and improve neurological outcomes in stroke patients." @default.
- W4308870591 created "2022-11-18" @default.
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- W4308870591 date "2022-11-10" @default.
- W4308870591 modified "2023-09-30" @default.
- W4308870591 title "Ischemic stroke and concomitant gastrointestinal complications- a fatal combination for patient recovery" @default.
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- W4308870591 cites W1974546936 @default.
- W4308870591 cites W1986205763 @default.
- W4308870591 cites W2002235841 @default.
- W4308870591 cites W2053216945 @default.
- W4308870591 cites W2060185417 @default.
- W4308870591 cites W2074901682 @default.
- W4308870591 cites W2112671019 @default.
- W4308870591 cites W2125826054 @default.
- W4308870591 cites W2135824704 @default.
- W4308870591 cites W2138168133 @default.
- W4308870591 cites W2149284219 @default.
- W4308870591 cites W2149474055 @default.
- W4308870591 cites W2150968312 @default.
- W4308870591 cites W2159103481 @default.
- W4308870591 cites W2186396569 @default.
- W4308870591 cites W2262898288 @default.
- W4308870591 cites W2332044667 @default.
- W4308870591 cites W2460079419 @default.
- W4308870591 cites W2480559039 @default.
- W4308870591 cites W2527885929 @default.
- W4308870591 cites W2555703786 @default.
- W4308870591 cites W2572551054 @default.
- W4308870591 cites W2587564932 @default.
- W4308870591 cites W2589529156 @default.
- W4308870591 cites W2615460620 @default.
- W4308870591 cites W2657252452 @default.
- W4308870591 cites W2710474729 @default.
- W4308870591 cites W2745506627 @default.
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- W4308870591 cites W2886952520 @default.
- W4308870591 cites W2887857133 @default.
- W4308870591 cites W2888655293 @default.
- W4308870591 cites W2905664198 @default.
- W4308870591 cites W2914245662 @default.
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- W4308870591 cites W2981831423 @default.
- W4308870591 cites W2998369522 @default.
- W4308870591 cites W2998380179 @default.
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- W4308870591 cites W3015574114 @default.
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- W4308870591 cites W3091808368 @default.
- W4308870591 cites W3092353927 @default.
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- W4308870591 cites W3129468155 @default.
- W4308870591 cites W3135791721 @default.
- W4308870591 cites W3137148958 @default.
- W4308870591 cites W3157215120 @default.
- W4308870591 cites W3158173344 @default.
- W4308870591 cites W3158649574 @default.
- W4308870591 cites W3184602749 @default.
- W4308870591 cites W3197233575 @default.
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- W4308870591 doi "https://doi.org/10.3389/fimmu.2022.1037330" @default.
- W4308870591 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36439129" @default.
- W4308870591 hasPublicationYear "2022" @default.
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