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- W4308875709 abstract "Treatment of bleeding and thrombotic disorders is highly standardized and based on evidence-based medicine guidelines. These evidence-based treatment schemes are well accepted but may lead to either insufficient treatment or over-dosing, because the individuals’ hemostatic properties are not taken into account. This can potentially introduce bleeding or thrombotic complications in individual patients. With the incorporation of pharmacokinetic (PK) and pharmacodynamic (PK-PD) parameters, based on global assays such as thrombin generation assays (TGAs), a more personalized approach can be applied to treat either bleeding or thrombotic disorders. In this review, we will discuss the recent literature about the technical aspects of TGAs and the relation to diagnosis and management of bleeding and thrombotic disorders. In patients with bleeding disorders, such as hemophilia A or factor VII deficiency, TGAs can be used to identify patients with a more severe bleeding phenotype and also in the management with non-replacement therapy and/or bypassing therapy. These assays have also a role in patients with venous thrombo-embolism, but the usage of TGAs in patients with arterial thrombosis is less clear. However, there is a potential role for TGAs in the monitoring of (long-term) antithrombotic therapy, for example with the use of direct oral anticoagulants. Finally this review will discuss controversies, limitations and knowledge gaps in relation to the introduction of TGAs to personalize medicine in daily medical practice." @default.
- W4308875709 created "2022-11-18" @default.
- W4308875709 creator A5022514883 @default.
- W4308875709 creator A5025607065 @default.
- W4308875709 creator A5037222042 @default.
- W4308875709 creator A5054098878 @default.
- W4308875709 creator A5085526211 @default.
- W4308875709 date "2022-11-10" @default.
- W4308875709 modified "2023-10-14" @default.
- W4308875709 title "Thrombin generation assays to personalize treatment in bleeding and thrombotic diseases" @default.
- W4308875709 cites W1499447375 @default.
- W4308875709 cites W1511902542 @default.
- W4308875709 cites W1516179239 @default.
- W4308875709 cites W1544456416 @default.
- W4308875709 cites W1575456191 @default.
- W4308875709 cites W1584325646 @default.
- W4308875709 cites W1628075576 @default.
- W4308875709 cites W1907847202 @default.
- W4308875709 cites W1950713902 @default.
- W4308875709 cites W1963731836 @default.
- W4308875709 cites W1969869573 @default.
- W4308875709 cites W1970393874 @default.
- W4308875709 cites W1971011626 @default.
- W4308875709 cites W1971014130 @default.
- W4308875709 cites W1971375546 @default.
- W4308875709 cites W1972343156 @default.
- W4308875709 cites W1973687787 @default.
- W4308875709 cites W1982221334 @default.
- W4308875709 cites W1984993382 @default.
- W4308875709 cites W1986291810 @default.
- W4308875709 cites W1992944529 @default.
- W4308875709 cites W1993331725 @default.
- W4308875709 cites W1994694158 @default.
- W4308875709 cites W1998317810 @default.
- W4308875709 cites W1999385881 @default.
- W4308875709 cites W2003820644 @default.
- W4308875709 cites W2005288249 @default.
- W4308875709 cites W2005877086 @default.
- W4308875709 cites W2006889910 @default.
- W4308875709 cites W2007160679 @default.
- W4308875709 cites W2011090717 @default.
- W4308875709 cites W2011852955 @default.
- W4308875709 cites W2014860066 @default.
- W4308875709 cites W2017345016 @default.
- W4308875709 cites W2023380848 @default.
- W4308875709 cites W2025070897 @default.
- W4308875709 cites W2026502021 @default.
- W4308875709 cites W2026954003 @default.
- W4308875709 cites W2027607061 @default.
- W4308875709 cites W2032524450 @default.
- W4308875709 cites W2033408014 @default.
- W4308875709 cites W2034257577 @default.
- W4308875709 cites W2035756723 @default.
- W4308875709 cites W2036317585 @default.
- W4308875709 cites W2038706245 @default.
- W4308875709 cites W2039675732 @default.
- W4308875709 cites W2040254529 @default.
- W4308875709 cites W2040917947 @default.
- W4308875709 cites W2041441905 @default.
- W4308875709 cites W2045539423 @default.
- W4308875709 cites W2047986798 @default.
- W4308875709 cites W2049370502 @default.
- W4308875709 cites W2050653642 @default.
- W4308875709 cites W2050760619 @default.
- W4308875709 cites W2051150132 @default.
- W4308875709 cites W2051674194 @default.
- W4308875709 cites W2053207101 @default.
- W4308875709 cites W2054330426 @default.
- W4308875709 cites W2057813521 @default.
- W4308875709 cites W2060779571 @default.
- W4308875709 cites W2065553417 @default.
- W4308875709 cites W2066015997 @default.
- W4308875709 cites W2066569278 @default.
- W4308875709 cites W2067747440 @default.
- W4308875709 cites W2070885572 @default.
- W4308875709 cites W2071039800 @default.
- W4308875709 cites W2071560225 @default.
- W4308875709 cites W2072493867 @default.
- W4308875709 cites W2076964609 @default.
- W4308875709 cites W2077094496 @default.
- W4308875709 cites W2077800201 @default.
- W4308875709 cites W2078476182 @default.
- W4308875709 cites W2085433233 @default.
- W4308875709 cites W2087783598 @default.
- W4308875709 cites W2087879607 @default.
- W4308875709 cites W2090739558 @default.
- W4308875709 cites W2104882374 @default.
- W4308875709 cites W2106813936 @default.
- W4308875709 cites W2122004095 @default.
- W4308875709 cites W2123242870 @default.
- W4308875709 cites W2124693396 @default.
- W4308875709 cites W2125074713 @default.
- W4308875709 cites W2128510061 @default.
- W4308875709 cites W2134359334 @default.
- W4308875709 cites W2135486988 @default.
- W4308875709 cites W2138914609 @default.
- W4308875709 cites W2139739213 @default.
- W4308875709 cites W2140508671 @default.
- W4308875709 cites W2145213708 @default.
- W4308875709 cites W2150835828 @default.