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- W4308885475 abstract "Phytochemicals capacity to reduce metal into nanoparticles has sparked a new eco-friendly method to build green nanotechnology. Synthesis of nanoparticles using a biological approach with valuable medicinal applications is an essential feature of modern nanotechnology. The present study attempts to synthesize silver (PE-AgNPs) and zinc oxide (PE-ZnONPs) nanoparticles using Phyllanthus emblica fruit ethanolic extract and evaluates their therapeutic potential. In our present study, the secondary metabolites of the extract were determined by Gas Chromatography-Mass Spectra (GC-MS.) Nanoparticles were characterized using analytical tools. The PE-AgNPs and PE-ZnONPs nanoparticles have shown potential inhibition activity against α-amylase (IC50 170.60 ± 0.94 and 160.82 ± 0.88 µg/mL), α-glucosidase (IC50 80.24 ± 1.38 and 70.02 ± 0.59 µg/mL) and increased glucose uptake (180.42 ± 0.78 and 110.52 ± 0.84 µg/mL). In-vitro MTT assay of PE-AgNPs and PE-ZnONPs nanoparticles revealed the effective anticancer potential against the A549 cancer cell line with an IC50 value of 27.52 ± 1.12 and 70.64 ± 1.4 µg/mL. The synthesized bioactive compounds can be the alternative eco-friendly potential for an antidiabetic and anticancer substitute which can be further recommended for pharmacological applications." @default.
- W4308885475 created "2022-11-18" @default.
- W4308885475 creator A5004324589 @default.
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- W4308885475 date "2022-11-09" @default.
- W4308885475 modified "2023-10-16" @default.
- W4308885475 title "Phytofabrication of silver and zinc oxide nanoparticles using the fruit extract of <i>Phyllanthus emblica</i> and its potential anti-diabetic and anti-cancer activity" @default.
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- W4308885475 doi "https://doi.org/10.1080/02726351.2022.2141668" @default.
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