Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308889193> ?p ?o ?g. }
- W4308889193 endingPage "109271" @default.
- W4308889193 startingPage "109271" @default.
- W4308889193 abstract "G-protein coupled receptor (GPCR) kinases (GRKs) and hypoxia-inducible factor-1α (HIF-1α) play key roles in rheumatoid arthritis (RA). Several studies have demonstrated that HIF-1α expression is positively regulated by GRK2, suggesting its posttranscriptional effects on HIF-1α. In this study, we review the role of HIF-1α and GRK2 in RA pathophysiology, focusing on their proinflammatory roles in immune cells and fibroblast-like synoviocytes (FLS). We then introduce several drugs that inhibit GRK2 and HIF-1α, and briefly outline their molecular mechanisms. We conclude by presenting gaps in knowledge and our prospects for the pharmacological potential of targeting these proteins and the relevant downstream signaling pathways. Future research is warranted and paramount for untangling these novel and promising roles for GRK2 and HIF-1α in RA." @default.
- W4308889193 created "2022-11-18" @default.
- W4308889193 creator A5041880317 @default.
- W4308889193 creator A5053849567 @default.
- W4308889193 creator A5057400188 @default.
- W4308889193 date "2022-12-01" @default.
- W4308889193 modified "2023-09-28" @default.
- W4308889193 title "Targeted inhibition of the GRK2/HIF-1α pathway is an effective strategy to alleviate synovial hypoxia and inflammation" @default.
- W4308889193 cites W1507326555 @default.
- W4308889193 cites W1549470277 @default.
- W4308889193 cites W1553817346 @default.
- W4308889193 cites W1829690624 @default.
- W4308889193 cites W1873126901 @default.
- W4308889193 cites W1914139652 @default.
- W4308889193 cites W1916913063 @default.
- W4308889193 cites W1949695329 @default.
- W4308889193 cites W1987973079 @default.
- W4308889193 cites W1992645971 @default.
- W4308889193 cites W1995687189 @default.
- W4308889193 cites W2007138098 @default.
- W4308889193 cites W2008214565 @default.
- W4308889193 cites W2010356452 @default.
- W4308889193 cites W2021214303 @default.
- W4308889193 cites W2023147140 @default.
- W4308889193 cites W2030405146 @default.
- W4308889193 cites W2037265282 @default.
- W4308889193 cites W2038974826 @default.
- W4308889193 cites W2041356495 @default.
- W4308889193 cites W2041734676 @default.
- W4308889193 cites W2056638001 @default.
- W4308889193 cites W2059000751 @default.
- W4308889193 cites W2061520029 @default.
- W4308889193 cites W2061946742 @default.
- W4308889193 cites W2065705503 @default.
- W4308889193 cites W2070837896 @default.
- W4308889193 cites W2074050752 @default.
- W4308889193 cites W2076357723 @default.
- W4308889193 cites W2081264165 @default.
- W4308889193 cites W2090513105 @default.
- W4308889193 cites W2097358746 @default.
- W4308889193 cites W2097833824 @default.
- W4308889193 cites W2098972920 @default.
- W4308889193 cites W2100256432 @default.
- W4308889193 cites W2103083504 @default.
- W4308889193 cites W2103154710 @default.
- W4308889193 cites W2104934425 @default.
- W4308889193 cites W2111993826 @default.
- W4308889193 cites W2127424619 @default.
- W4308889193 cites W2134053452 @default.
- W4308889193 cites W2136368623 @default.
- W4308889193 cites W2137465719 @default.
- W4308889193 cites W2141612579 @default.
- W4308889193 cites W2143158290 @default.
- W4308889193 cites W2144625075 @default.
- W4308889193 cites W2145335113 @default.
- W4308889193 cites W2150288446 @default.
- W4308889193 cites W2155872278 @default.
- W4308889193 cites W2162107249 @default.
- W4308889193 cites W2162565421 @default.
- W4308889193 cites W2162595421 @default.
- W4308889193 cites W2170854823 @default.
- W4308889193 cites W2189560780 @default.
- W4308889193 cites W2190420537 @default.
- W4308889193 cites W2279191723 @default.
- W4308889193 cites W2312301681 @default.
- W4308889193 cites W2319048466 @default.
- W4308889193 cites W2335232122 @default.
- W4308889193 cites W2398478012 @default.
- W4308889193 cites W2416263718 @default.
- W4308889193 cites W2427701618 @default.
- W4308889193 cites W2470878467 @default.
- W4308889193 cites W2537440061 @default.
- W4308889193 cites W2554588950 @default.
- W4308889193 cites W2594169418 @default.
- W4308889193 cites W2599080348 @default.
- W4308889193 cites W2605741546 @default.
- W4308889193 cites W2605773822 @default.
- W4308889193 cites W2606626763 @default.
- W4308889193 cites W2621296296 @default.
- W4308889193 cites W2731571107 @default.
- W4308889193 cites W2747197979 @default.
- W4308889193 cites W2763886444 @default.
- W4308889193 cites W2764092921 @default.
- W4308889193 cites W2766504508 @default.
- W4308889193 cites W2769847562 @default.
- W4308889193 cites W2770038543 @default.
- W4308889193 cites W2784023062 @default.
- W4308889193 cites W2784405670 @default.
- W4308889193 cites W2799871629 @default.
- W4308889193 cites W2803001736 @default.
- W4308889193 cites W2806143370 @default.
- W4308889193 cites W2886434092 @default.
- W4308889193 cites W2887790836 @default.
- W4308889193 cites W2892506986 @default.
- W4308889193 cites W2898840093 @default.
- W4308889193 cites W2901245523 @default.
- W4308889193 cites W2905523914 @default.
- W4308889193 cites W2908438882 @default.