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- W4308890656 abstract "In mammals, primordial germ cells (PGCs) enter meiosis and differentiate into primary oocytes in embryonic ovaries. Previously, we demonstrated that meiotic gene induction and meiotic initiation were impaired in female germline cells of conditional knockout (CKO) mice lacking the Smarcb1 (Snf5) gene, which encodes a core subunit of the switching defective/sucrose non-fermenting (SWI/SNF) complex. In this study, we classified meiotic genes expressed at lower levels in Snf5 CKO females into two groups based on promoter accessibility. The promoters of 74% of these genes showed lower accessibility in mutant mice, whereas those of the remaining genes were opened without the SWI/SNF complex. Notably, the former genes included Meiosin, which encodes a transcriptional regulator essential for meiotic gene activation. The promoters of the former and the latter genes were mainly modified with H3K27me3/bivalent and H3K4me3 histone marks, respectively. A subset of the former genes was precociously activated in female PGCs deficient in polycomb repressive complexes (PRCs). Our results point to a mechanism through which the SWI/SNF complex coordinates meiotic gene activation via the remodeling of PRC-repressed genes, including Meiosin, in female germline cells." @default.
- W4308890656 created "2022-11-18" @default.
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- W4308890656 date "2022-11-20" @default.
- W4308890656 modified "2023-10-16" @default.
- W4308890656 title "Switching defective/sucrose non‐fermenting chromatin remodeling complex coordinates meiotic gene activation via promoter remodeling and <i>Meiosin</i> activation in female germline" @default.
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- W4308890656 doi "https://doi.org/10.1111/gtc.12990" @default.
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