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- W4308895022 abstract "Abstract Zoonotic poxvirus infections pose significant threat to human health as we have witnessed recent spread of monkeypox. Therefore, insights into molecular mechanism behind poxvirus replication cycle are needed for the development of efficient antiviral strategies. Virion assembly is one of the key steps that determine the fate of replicating poxviruses. However, in-depth understanding of poxvirus assembly is challenging due to the complex nature of multi-step morphogenesis and heterogeneous virion structures. Despite these challenges, decades of research have revealed virion morphologies at various maturation stages, critical protein components and interactions with host cell compartments. Transmission electron microscopy has been employed as an indispensable tool for the examination of virion morphology, and more recently for the structure determination of protein complexes. In this review, we describe some of the major findings in poxvirus morphogenesis and the contributions of continuously advancing electron microscopy techniques." @default.
- W4308895022 created "2022-11-18" @default.
- W4308895022 creator A5011729658 @default.
- W4308895022 date "2022-11-14" @default.
- W4308895022 modified "2023-09-26" @default.
- W4308895022 title "Poxvirus under the eyes of electron microscope" @default.
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- W4308895022 doi "https://doi.org/10.1186/s42649-022-00080-3" @default.
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