FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308902479> ?p ?o ?g. }

• W4308902479 endingPage "6213" @default.
• W4308902479 startingPage "6206" @default.
• W4308902479 abstract "Gulf War Illness (GWI) is a chronic illness that affects upward of 32% of deployed Veterans to the 1991 Gulf War (GW). The symptoms are medically unexplained, ranging across cognitive deficits, fatigue, gastrointestinal problems, and musculoskeletal pain. Research indicates that chemical warfare agents play a key role in the onset and progression of GWI. The Khamisiyah ammunition storage that housed chemical warfare agents such as sarin, an acetylcholinesterase (AChE) inhibitor, was demolished during the GW, releasing toxicants into the atmosphere affecting deployed troops. Exposure to other chemical agest such as pyridostigmine bromide , N,N-diethyl-m-toluamide, permethrin and chlorpyrifos, were also prevalent during the war. These additional chemical agents have also been shown to inhibit AChE. AChE inhibition induces an acetylcholine build-up, disrupting signals between nerves and muscles, which in high doses leads to asphyxiation. Little is known about low dose exposure. As bioactive compounds tend to interact with multiple proteins with various physiological effect, we aimed to identify other potential shared targets to understand the extent in which these chemicals could lead to GWI. We followed a reverse screening approach where each chemical is computationally docked to a library of protein targets. The programs PharmMapper and TargetNet were sued for this purpose, and further analyses were conducted to mark significant changes in participants with GWI. Previously published work on DNA methylation status in GWI was reanalyzed focusing specifically on the predicted shared targets indicating significant changes in DNA methylation of the associated genes. Our findings thus suggest that exposure to GWI-related agents, may converge on similar targets with roles in inflammation, neurotransmitters and lipid metabolism, and detoxification which may have impacts on neurodegenerative-like disease and oxidative stress in Veterans with GWI." @default.
• W4308902479 created "2022-11-19" @default.
• W4308902479 creator A5003877429 @default.
• W4308902479 creator A5011861328 @default.
• W4308902479 creator A5025035847 @default.
• W4308902479 creator A5039742029 @default.
• W4308902479 creator A5041794756 @default.
• W4308902479 creator A5073639496 @default.
• W4308902479 creator A5089175484 @default.
• W4308902479 date "2022-01-01" @default.
• W4308902479 modified "2023-10-14" @default.
• W4308902479 title "A pilot reverse virtual screening study suggests toxic exposures caused long-term epigenetic changes in Gulf War Illness" @default.
• W4308902479 cites W1502508988 @default.
• W4308902479 cites W1541662874 @default.
• W4308902479 cites W1825970932 @default.
• W4308902479 cites W1968682237 @default.
• W4308902479 cites W1971443047 @default.
• W4308902479 cites W1972814339 @default.
• W4308902479 cites W1985517047 @default.
• W4308902479 cites W1989277387 @default.
• W4308902479 cites W1990043489 @default.
• W4308902479 cites W1998767819 @default.
• W4308902479 cites W2005639991 @default.
• W4308902479 cites W2009638691 @default.
• W4308902479 cites W2010431921 @default.
• W4308902479 cites W2016704355 @default.
• W4308902479 cites W2017138237 @default.
• W4308902479 cites W2021429428 @default.
• W4308902479 cites W2022853768 @default.
• W4308902479 cites W2028876181 @default.
• W4308902479 cites W2039802164 @default.
• W4308902479 cites W2040135138 @default.
• W4308902479 cites W2044659434 @default.
• W4308902479 cites W2052126689 @default.
• W4308902479 cites W2055885996 @default.
• W4308902479 cites W2059377985 @default.
• W4308902479 cites W2081518434 @default.
• W4308902479 cites W2085398335 @default.
• W4308902479 cites W2093020725 @default.
• W4308902479 cites W2104916446 @default.
• W4308902479 cites W2105381419 @default.
• W4308902479 cites W2108558950 @default.
• W4308902479 cites W2111377178 @default.
• W4308902479 cites W2112872187 @default.
• W4308902479 cites W2114884647 @default.
• W4308902479 cites W2117711928 @default.
• W4308902479 cites W2138393164 @default.
• W4308902479 cites W2140291328 @default.
• W4308902479 cites W2150420891 @default.
• W4308902479 cites W2151014102 @default.
• W4308902479 cites W2152656267 @default.
• W4308902479 cites W2158609797 @default.
• W4308902479 cites W2169678694 @default.
• W4308902479 cites W2170469583 @default.
• W4308902479 cites W2177317049 @default.
• W4308902479 cites W2206368938 @default.
• W4308902479 cites W2208500123 @default.
• W4308902479 cites W2281209287 @default.
• W4308902479 cites W2341428327 @default.
• W4308902479 cites W2362265365 @default.
• W4308902479 cites W2407564830 @default.
• W4308902479 cites W2513364739 @default.
• W4308902479 cites W2530939851 @default.
• W4308902479 cites W2569489860 @default.
• W4308902479 cites W2576115999 @default.
• W4308902479 cites W2611425558 @default.
• W4308902479 cites W2613979314 @default.
• W4308902479 cites W2733170430 @default.
• W4308902479 cites W2750064078 @default.
• W4308902479 cites W2802492120 @default.
• W4308902479 cites W2885095741 @default.
• W4308902479 cites W2888522738 @default.
• W4308902479 cites W2895464606 @default.
• W4308902479 cites W2896369958 @default.
• W4308902479 cites W2899070097 @default.
• W4308902479 cites W2901710743 @default.
• W4308902479 cites W2935081667 @default.
• W4308902479 cites W2948177654 @default.
• W4308902479 cites W2952085241 @default.
• W4308902479 cites W2966261526 @default.
• W4308902479 cites W2996488598 @default.
• W4308902479 cites W3025237372 @default.
• W4308902479 cites W3137164735 @default.
• W4308902479 cites W3190265111 @default.
• W4308902479 cites W3217632966 @default.
• W4308902479 cites W4231254854 @default.
• W4308902479 cites W4238662802 @default.
• W4308902479 cites W4238683730 @default.
• W4308902479 cites W4244311005 @default.
• W4308902479 cites W4252273568 @default.
• W4308902479 doi "https://doi.org/10.1016/j.csbj.2022.11.006" @default.
• W4308902479 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36420170" @default.
• W4308902479 hasPublicationYear "2022" @default.
• W4308902479 type Work @default.
• W4308902479 citedByCount "0" @default.
• W4308902479 crossrefType "journal-article" @default.
• W4308902479 hasAuthorship W4308902479A5003877429 @default.
• W4308902479 hasAuthorship W4308902479A5011861328 @default.

• next