FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308923218> ?p ?o ?g. }

• W4308923218 endingPage "102945" @default.
• W4308923218 startingPage "102945" @default.
• W4308923218 abstract "Monocytes in peripheral blood and sciatic nerves play vital roles in immune-mediated neuropathies such as Guillain-Barré syndrome (GBS). Different subpopulations of monocytes, including classical and non-classical, exhibit distinct functions as well as phenotypic conversion potentials. However, the mechanisms underlying their development during immune-mediated neuropathy remain unclear. Notch signaling participates in monocyte differentiation and function. In this study, we used a myeloid-specific Notch signaling activation transgenic mouse (NICcA) and investigated the role of Notch signaling in monocytes during experimental autoimmune neuritis (EAN) in a mouse model of GBS. Clinical score assessment and histopathological examination revealed that sciatic nerve injury was attenuated in NICcA EAN mice compared to that in control mice. Flow cytometry and immunofluorescence staining suggested that increasing Ly6Clo monocytes in the peripheral blood and nerve tissue might contribute to the alleviation of neuritis in NICcA mice. Meanwhile, an in vitro study suggested that bone marrow-derived monocytes from NICcA mice are more inclined toward Ly6Clo cells than Ly6Chi cells. Differential expression of monocyte development-associated genes was detected in NICcA and wild-type mice using RNA sequencing. The expression of Nr4a1 is upregulated remarkably when Notch signaling is activated. Treatment with Nr4a1 antagonist on NICcA mice-derived monocytes compromise their Ly6Clo tendency. Consistently, a relationship between monocyte conversion and disease severity was observed in blood samples from patients with GBS. In conclusion, our current study showed that monocyte conversion modulated by Notch signaling plays an essential role in the EAN mouse model." @default.
• W4308923218 created "2022-11-19" @default.
• W4308923218 creator A5005099994 @default.
• W4308923218 creator A5017612987 @default.
• W4308923218 creator A5027459053 @default.
• W4308923218 creator A5030825527 @default.
• W4308923218 creator A5033616351 @default.
• W4308923218 creator A5040845802 @default.
• W4308923218 creator A5041468811 @default.
• W4308923218 creator A5048009692 @default.
• W4308923218 creator A5051419857 @default.
• W4308923218 creator A5063978160 @default.
• W4308923218 creator A5081270594 @default.
• W4308923218 creator A5082048769 @default.
• W4308923218 date "2022-12-01" @default.
• W4308923218 modified "2023-10-10" @default.
• W4308923218 title "Notch signaling dependent monocyte conversion alleviates immune-mediated neuropathies by regulating RBP-J/NR4A1 axis" @default.
• W4308923218 cites W1898917894 @default.
• W4308923218 cites W1931644846 @default.
• W4308923218 cites W1998779709 @default.
• W4308923218 cites W2022430696 @default.
• W4308923218 cites W2070515443 @default.
• W4308923218 cites W2071138356 @default.
• W4308923218 cites W2124392720 @default.
• W4308923218 cites W2148724499 @default.
• W4308923218 cites W2153406260 @default.
• W4308923218 cites W2154578159 @default.
• W4308923218 cites W2154861644 @default.
• W4308923218 cites W2159662576 @default.
• W4308923218 cites W2160331242 @default.
• W4308923218 cites W2269645281 @default.
• W4308923218 cites W2512649632 @default.
• W4308923218 cites W2536640519 @default.
• W4308923218 cites W2614302084 @default.
• W4308923218 cites W2626120438 @default.
• W4308923218 cites W2782635009 @default.
• W4308923218 cites W2801591283 @default.
• W4308923218 cites W2883857532 @default.
• W4308923218 cites W2897749707 @default.
• W4308923218 cites W2897945399 @default.
• W4308923218 cites W2945781043 @default.
• W4308923218 cites W2946468288 @default.
• W4308923218 cites W2997642361 @default.
• W4308923218 cites W3014266030 @default.
• W4308923218 cites W3016216803 @default.
• W4308923218 cites W3018907963 @default.
• W4308923218 cites W3036265910 @default.
• W4308923218 cites W3120407075 @default.
• W4308923218 cites W3137498288 @default.
• W4308923218 cites W3158527041 @default.
• W4308923218 cites W3195907693 @default.
• W4308923218 cites W4213034925 @default.
• W4308923218 cites W4221003866 @default.
• W4308923218 cites W82909710 @default.
• W4308923218 doi "https://doi.org/10.1016/j.jaut.2022.102945" @default.
• W4308923218 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36356552" @default.
• W4308923218 hasPublicationYear "2022" @default.
• W4308923218 type Work @default.
• W4308923218 citedByCount "2" @default.
• W4308923218 countsByYear W43089232182023 @default.
• W4308923218 crossrefType "journal-article" @default.
• W4308923218 hasAuthorship W4308923218A5005099994 @default.
• W4308923218 hasAuthorship W4308923218A5017612987 @default.
• W4308923218 hasAuthorship W4308923218A5027459053 @default.
• W4308923218 hasAuthorship W4308923218A5030825527 @default.
• W4308923218 hasAuthorship W4308923218A5033616351 @default.
• W4308923218 hasAuthorship W4308923218A5040845802 @default.
• W4308923218 hasAuthorship W4308923218A5041468811 @default.
• W4308923218 hasAuthorship W4308923218A5048009692 @default.
• W4308923218 hasAuthorship W4308923218A5051419857 @default.
• W4308923218 hasAuthorship W4308923218A5063978160 @default.
• W4308923218 hasAuthorship W4308923218A5081270594 @default.
• W4308923218 hasAuthorship W4308923218A5082048769 @default.
• W4308923218 hasConcept C161879069 @default.
• W4308923218 hasConcept C203014093 @default.
• W4308923218 hasConcept C2781184567 @default.
• W4308923218 hasConcept C553184892 @default.
• W4308923218 hasConcept C62478195 @default.
• W4308923218 hasConcept C71924100 @default.
• W4308923218 hasConcept C86803240 @default.
• W4308923218 hasConcept C8891405 @default.
• W4308923218 hasConcept C95444343 @default.
• W4308923218 hasConceptScore W4308923218C161879069 @default.
• W4308923218 hasConceptScore W4308923218C203014093 @default.
• W4308923218 hasConceptScore W4308923218C2781184567 @default.
• W4308923218 hasConceptScore W4308923218C553184892 @default.
• W4308923218 hasConceptScore W4308923218C62478195 @default.
• W4308923218 hasConceptScore W4308923218C71924100 @default.
• W4308923218 hasConceptScore W4308923218C86803240 @default.
• W4308923218 hasConceptScore W4308923218C8891405 @default.
• W4308923218 hasConceptScore W4308923218C95444343 @default.
• W4308923218 hasFunder F4320321001 @default.
• W4308923218 hasFunder F4320336350 @default.
• W4308923218 hasLocation W43089232181 @default.
• W4308923218 hasLocation W43089232182 @default.
• W4308923218 hasOpenAccess W4308923218 @default.
• W4308923218 hasPrimaryLocation W43089232181 @default.
• W4308923218 hasRelatedWork W1978215356 @default.

• next