FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308927954> ?p ?o ?g. }

• W4308927954 endingPage "122388" @default.
• W4308927954 startingPage "122388" @default.
• W4308927954 abstract "Limited oral bioavailability due to high hydrophilicity restricts the beneficial use of Rosmaranic acid (RM) that is characterized by many biological and pharmacological effects. The present work was addressed to extract RM from Rosmarinus officinalis L. leaves and then increase its lipophilicity and permeability through the application of hydrophobic ion pair (HIP) approach using ethyl lauroyl arginate (ELA) as a novel counter-ion. Different RM:ELA ratios were screened to optimize HIP formation process. The encapsulation of the optimized HIP into lipid nanocapsules (LNCs) was then achieved to facilitate oral administration. The results of % transmittance, % complexation efficiency (87.32 ± 0.19%) and partition coefficient revealed the successful formation of the HIP complex occurred at RM:ELA molar ratio of 1:2. The formed HIP was successfully loaded into spherical small sized (39.32 ± 0.18 nm) LNCs. The ex vivo permeability studies across porcine intestine showed that the cumulative RM amount permeated/area after 6 h from HIP and LNCs were 3.79 ± 0.57 and 5.71 ± 0.32 µg/cm2, respectively. Pharmacokinetic study results showed that the maximum RM concentrations in plasma (Cmax) can be arranged in a descending manner as follows; 61.33 ± 8.89 < 42.13 ± 11.22 < 20.96 ± 3.12 ng/ml attained after 4.80, 8.00 and 10.40 h in case of LNC, HIP and solution, respectively. Moreover, the HIP and LNC formulae showed higher total drug amounts in plasma reaching 1.46 and 1.88-fold relative to RM solution, respectively. In conclusion, the HIP complex and HIP loaded LNCs prosper in enhancing the permeability and absorption of the low permeable drugs." @default.
• W4308927954 created "2022-11-19" @default.
• W4308927954 creator A5020645598 @default.
• W4308927954 creator A5025797697 @default.
• W4308927954 creator A5074588284 @default.
• W4308927954 creator A5077416547 @default.
• W4308927954 date "2023-01-01" @default.
• W4308927954 modified "2023-10-05" @default.
• W4308927954 title "Ethyl lauroyl arginate-based hydrophobic ion pair complex in lipid nanocapsules: A novel oral delivery approach of rosmarinic acid for enhanced permeability and bioavailability" @default.
• W4308927954 cites W1205374584 @default.
• W4308927954 cites W1968418753 @default.
• W4308927954 cites W1972544735 @default.
• W4308927954 cites W1974814769 @default.
• W4308927954 cites W1976476854 @default.
• W4308927954 cites W1977489898 @default.
• W4308927954 cites W1989619366 @default.
• W4308927954 cites W2018502502 @default.
• W4308927954 cites W2062690180 @default.
• W4308927954 cites W2102182534 @default.
• W4308927954 cites W2143336736 @default.
• W4308927954 cites W2150855779 @default.
• W4308927954 cites W2338591330 @default.
• W4308927954 cites W2341264908 @default.
• W4308927954 cites W2496907023 @default.
• W4308927954 cites W2518300805 @default.
• W4308927954 cites W2539553165 @default.
• W4308927954 cites W2581288809 @default.
• W4308927954 cites W2581509014 @default.
• W4308927954 cites W2741540803 @default.
• W4308927954 cites W2743736876 @default.
• W4308927954 cites W2806096336 @default.
• W4308927954 cites W2807209520 @default.
• W4308927954 cites W2883557476 @default.
• W4308927954 cites W2883828549 @default.
• W4308927954 cites W2895181790 @default.
• W4308927954 cites W2913896208 @default.
• W4308927954 cites W2945740370 @default.
• W4308927954 cites W2964368704 @default.
• W4308927954 cites W2977996654 @default.
• W4308927954 cites W2978421255 @default.
• W4308927954 cites W2987932370 @default.
• W4308927954 cites W3006266588 @default.
• W4308927954 cites W3007231703 @default.
• W4308927954 cites W3138066476 @default.
• W4308927954 cites W3156339738 @default.
• W4308927954 cites W3162978196 @default.
• W4308927954 cites W3163033986 @default.
• W4308927954 cites W3168255854 @default.
• W4308927954 cites W3203432456 @default.
• W4308927954 cites W4205195377 @default.
• W4308927954 cites W4223509063 @default.
• W4308927954 cites W4288758339 @default.
• W4308927954 doi "https://doi.org/10.1016/j.ijpharm.2022.122388" @default.
• W4308927954 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36375682" @default.
• W4308927954 hasPublicationYear "2023" @default.
• W4308927954 type Work @default.
• W4308927954 citedByCount "2" @default.
• W4308927954 countsByYear W43089279542023 @default.
• W4308927954 crossrefType "journal-article" @default.
• W4308927954 hasAuthorship W4308927954A5020645598 @default.
• W4308927954 hasAuthorship W4308927954A5025797697 @default.
• W4308927954 hasAuthorship W4308927954A5074588284 @default.
• W4308927954 hasAuthorship W4308927954A5077416547 @default.
• W4308927954 hasConcept C112705442 @default.
• W4308927954 hasConcept C155672457 @default.
• W4308927954 hasConcept C171250308 @default.
• W4308927954 hasConcept C181389837 @default.
• W4308927954 hasConcept C185592680 @default.
• W4308927954 hasConcept C192552737 @default.
• W4308927954 hasConcept C192562407 @default.
• W4308927954 hasConcept C201399114 @default.
• W4308927954 hasConcept C204399865 @default.
• W4308927954 hasConcept C22979827 @default.
• W4308927954 hasConcept C43617362 @default.
• W4308927954 hasConcept C71240020 @default.
• W4308927954 hasConcept C71924100 @default.
• W4308927954 hasConcept C98274493 @default.
• W4308927954 hasConceptScore W4308927954C112705442 @default.
• W4308927954 hasConceptScore W4308927954C155672457 @default.
• W4308927954 hasConceptScore W4308927954C171250308 @default.
• W4308927954 hasConceptScore W4308927954C181389837 @default.
• W4308927954 hasConceptScore W4308927954C185592680 @default.
• W4308927954 hasConceptScore W4308927954C192552737 @default.
• W4308927954 hasConceptScore W4308927954C192562407 @default.
• W4308927954 hasConceptScore W4308927954C201399114 @default.
• W4308927954 hasConceptScore W4308927954C204399865 @default.
• W4308927954 hasConceptScore W4308927954C22979827 @default.
• W4308927954 hasConceptScore W4308927954C43617362 @default.
• W4308927954 hasConceptScore W4308927954C71240020 @default.
• W4308927954 hasConceptScore W4308927954C71924100 @default.
• W4308927954 hasConceptScore W4308927954C98274493 @default.
• W4308927954 hasFunder F4320321119 @default.
• W4308927954 hasLocation W43089279541 @default.
• W4308927954 hasLocation W43089279542 @default.
• W4308927954 hasOpenAccess W4308927954 @default.
• W4308927954 hasPrimaryLocation W43089279541 @default.
• W4308927954 hasRelatedWork W1534373964 @default.
• W4308927954 hasRelatedWork W1975321157 @default.

• next