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• W4308930536 endingPage "110910" @default.
• W4308930536 startingPage "110910" @default.
• W4308930536 abstract "Alkaline phosphatase (ALP), as a vital hydrolase, abnormal level can cause tissue damage and induce several diseases. Therefore, it is regarded as an important biomarker in clinical diagnostic medicine. Herein, we developed a highly selective and sensitive near-infrared (NIR) ratiometric fluorescent probe (YJ) for real-time monitoring of ALP activity in vitro and vivo . Notably, as reported so far, YJ has the shortest response time (within 5 min) among the NIR ratiometric ALP fluorescent probes. In addition, YJ shows exceptional fluorescence properties such as a large Stokes shift (160 nm), low detection limit (2.36 U L −1 ), the ratiometric determination of ALP at 570 nm and 667 nm, low cytotoxicity and strong anti-interference ability. Moreover, we not only successfully detected the level of endogenous ALP in living cells with YJ, but also tracked and monitored the spatial localization of endogenous ALP activities in zebrafish caused by APAP-induced organ damage. • Developed a NIR fluorescent probe with a self-immolative spacer for ratiometric detection of ALP. • The probe has the fastest response speed among the ratiometric ALP fluorescence probes, as reported so far. • The probe shows large stokes shift, high selectivity and low detection limit. • The probe can image endogenous ALP in living cells and zabrafish. • The probe has potential for evaluating drug-induced liver injury." @default.
• W4308930536 created "2022-11-19" @default.
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• W4308930536 date "2023-02-01" @default.
• W4308930536 modified "2023-10-18" @default.
• W4308930536 title "Near-infrared fluorescent probe with a self-immolative spacer for ratiometric imaging alkaline phosphatase in cell and zebrafish" @default.
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• W4308930536 doi "https://doi.org/10.1016/j.dyepig.2022.110910" @default.
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