FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308949069> ?p ?o ?g. }

• W4308949069 endingPage "1019" @default.
• W4308949069 startingPage "1011" @default.
• W4308949069 abstract "Hydrogel microneedles represent a promising approach to deliver drug molecules across skin into systemic circulation in a sustained release manner and without any polymer residue within skin. Acyclovir is an antiviral drug used for the treatment of several viral infections. However, the oral administration of acyclovir may cause gastrointestinal tract (GIT) disturbances with low bioavailability and poor patient compliance due to its requirement of five daily administrations to produce the desired effect. Therefore, it is thought that the preparation of hydrogel microneedle arrays containing acyclovir would improve the bioavailability and patient compliance by reducing the frequency of administration to once daily as well as overcome the GIT side effects associated with oral administration. A mixture of PEG 10,000 Da and PMVE/MA co-polymer 1,980,000 Da at a ratio of 1:3 (7.5%:22.5% w/w) with Na2CO3 3% w/w was found to produce the optimum hydrogel microneedle array formulation (F8) which showed suitable needle formation with an appropriate mechanical strength and excellent insertion ability, high drug content, sufficient swelling property and a sustained drug release over a period of 24 hours. The Ex vivo permeation study across human skin has demonstrated that the permeation of acyclovir from F8 hydrogel microneedle array was significantly (P ≤ 0.05) increased by 39 times in comparison with microneedle-free film (control). The microneedle array has delivered 75.56% ± 4.2 of its loading dose over 24 hours, while the control film was only able to deliver 1.94% ± 0.14 of the total loading dose during the same period. Accordingly, these findings propose the potential application of hydrogel microneedle arrays for the transdermal delivery of acyclovir in a sustained release manner over 24 hours." @default.
• W4308949069 created "2022-11-20" @default.
• W4308949069 creator A5011530969 @default.
• W4308949069 creator A5016607821 @default.
• W4308949069 creator A5023556737 @default.
• W4308949069 date "2023-04-01" @default.
• W4308949069 modified "2023-10-02" @default.
• W4308949069 title "Enhanced Transdermal Delivery of Acyclovir via Hydrogel Microneedle Arrays" @default.
• W4308949069 cites W1983717650 @default.
• W4308949069 cites W2001293346 @default.
• W4308949069 cites W2007539416 @default.
• W4308949069 cites W2033852627 @default.
• W4308949069 cites W2037721260 @default.
• W4308949069 cites W2046771069 @default.
• W4308949069 cites W2054294261 @default.
• W4308949069 cites W2055070607 @default.
• W4308949069 cites W2061496572 @default.
• W4308949069 cites W2065845122 @default.
• W4308949069 cites W2075001207 @default.
• W4308949069 cites W2077136599 @default.
• W4308949069 cites W2080430067 @default.
• W4308949069 cites W2111750633 @default.
• W4308949069 cites W2132349584 @default.
• W4308949069 cites W2153198431 @default.
• W4308949069 cites W2159458195 @default.
• W4308949069 cites W2160760798 @default.
• W4308949069 cites W2162853758 @default.
• W4308949069 cites W2168292600 @default.
• W4308949069 cites W2619444438 @default.
• W4308949069 cites W2736022621 @default.
• W4308949069 cites W2741124443 @default.
• W4308949069 cites W2775039942 @default.
• W4308949069 cites W2804689657 @default.
• W4308949069 cites W2855666604 @default.
• W4308949069 cites W2899970640 @default.
• W4308949069 cites W3007222749 @default.
• W4308949069 cites W3007629870 @default.
• W4308949069 cites W3035844765 @default.
• W4308949069 cites W3107004221 @default.
• W4308949069 cites W4206582282 @default.
• W4308949069 cites W4361798444 @default.
• W4308949069 doi "https://doi.org/10.1016/j.xphs.2022.11.012" @default.
• W4308949069 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36384194" @default.
• W4308949069 hasPublicationYear "2023" @default.
• W4308949069 type Work @default.
• W4308949069 citedByCount "1" @default.
• W4308949069 countsByYear W43089490692023 @default.
• W4308949069 crossrefType "journal-article" @default.
• W4308949069 hasAuthorship W4308949069A5011530969 @default.
• W4308949069 hasAuthorship W4308949069A5016607821 @default.
• W4308949069 hasAuthorship W4308949069A5023556737 @default.
• W4308949069 hasConcept C136229726 @default.
• W4308949069 hasConcept C150903083 @default.
• W4308949069 hasConcept C171250308 @default.
• W4308949069 hasConcept C181389837 @default.
• W4308949069 hasConcept C185592680 @default.
• W4308949069 hasConcept C192562407 @default.
• W4308949069 hasConcept C202751555 @default.
• W4308949069 hasConcept C205679159 @default.
• W4308949069 hasConcept C207001950 @default.
• W4308949069 hasConcept C26291073 @default.
• W4308949069 hasConcept C2779820397 @default.
• W4308949069 hasConcept C2780035454 @default.
• W4308949069 hasConcept C41625074 @default.
• W4308949069 hasConcept C50670333 @default.
• W4308949069 hasConcept C55493867 @default.
• W4308949069 hasConcept C71924100 @default.
• W4308949069 hasConcept C77281830 @default.
• W4308949069 hasConcept C86803240 @default.
• W4308949069 hasConcept C98274493 @default.
• W4308949069 hasConceptScore W4308949069C136229726 @default.
• W4308949069 hasConceptScore W4308949069C150903083 @default.
• W4308949069 hasConceptScore W4308949069C171250308 @default.
• W4308949069 hasConceptScore W4308949069C181389837 @default.
• W4308949069 hasConceptScore W4308949069C185592680 @default.
• W4308949069 hasConceptScore W4308949069C192562407 @default.
• W4308949069 hasConceptScore W4308949069C202751555 @default.
• W4308949069 hasConceptScore W4308949069C205679159 @default.
• W4308949069 hasConceptScore W4308949069C207001950 @default.
• W4308949069 hasConceptScore W4308949069C26291073 @default.
• W4308949069 hasConceptScore W4308949069C2779820397 @default.
• W4308949069 hasConceptScore W4308949069C2780035454 @default.
• W4308949069 hasConceptScore W4308949069C41625074 @default.
• W4308949069 hasConceptScore W4308949069C50670333 @default.
• W4308949069 hasConceptScore W4308949069C55493867 @default.
• W4308949069 hasConceptScore W4308949069C71924100 @default.
• W4308949069 hasConceptScore W4308949069C77281830 @default.
• W4308949069 hasConceptScore W4308949069C86803240 @default.
• W4308949069 hasConceptScore W4308949069C98274493 @default.
• W4308949069 hasFunder F4320328902 @default.
• W4308949069 hasIssue "4" @default.
• W4308949069 hasLocation W43089490691 @default.
• W4308949069 hasLocation W43089490692 @default.
• W4308949069 hasOpenAccess W4308949069 @default.
• W4308949069 hasPrimaryLocation W43089490691 @default.
• W4308949069 hasRelatedWork W1496163790 @default.
• W4308949069 hasRelatedWork W2005338850 @default.
• W4308949069 hasRelatedWork W2148155639 @default.

• next