FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308952010> ?p ?o ?g. }

• W4308952010 abstract "Abstract Background: Several studies had shown that the ubiquitin D (UBD) could be a potential prognostic factor in various cancers. However, the prognostic value of UBD in glioma remained unknown. Materials and Methods: The differences of UBD expression in glioma were analyzed based on the datasets of the Cancer Genome Atlas database (TCGA) and Chinese Glioma Genome Atlas (CGGA) and identified by qRT-PCR and western blot. Gene Ontology (GO) enrichment, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, and Gene set enrichment analysis (GSEA) were used to determine the functions of UBD. Moreover, the protein network of UBD was constructed using Cytoscape software. A spearman’s correlation analysis was performed to determine the association between UBD expression and immune cell infiltration. Additionally, a logistic regression analysis was performed to analyze the association between UBD expression and the clinicopathological characteristics of the glioma patients. The diagnostic and prognostic predictive values of UBD were evaluated using the Kaplan–Meier survival curves, Cox regression analysis, diagnostic receiver operating characteristic (ROC) curves, and nomogram model. Finally, the biological function of UBD was determined by wound healing assays, transwell assays, EdU and colony formation assays. Results: UBD expression in glioma samples was considerably increased, which was associated with the P53 pathway, angiogenesis, inflammatory response, TNFα -NF-κB signaling, IL-6-JAK-STAT3 signaling, PI3K-AKT-mTOR signaling, TGF-β signaling, KRAS signaling, as well as hypoxia, and epithelial-mesenchymal transition (EMT). UBD expression correlated with the infiltration level of immune cells through the ssGSEA method. High UBD expression was an independent prognostic factor of glioma in TCGA. ROC curve analysis showed good diagnostic efficacy of UBD in glioma. Furthermore, UBD could increase the migration, invasion and proliferation ability of glioma cells. Conclusion: UBD may be a potential prognostic marker and therapeutic target in glioma." @default.
• W4308952010 created "2022-11-20" @default.
• W4308952010 creator A5014268033 @default.
• W4308952010 creator A5024818901 @default.
• W4308952010 creator A5043100976 @default.
• W4308952010 creator A5056202501 @default.
• W4308952010 creator A5069672266 @default.
• W4308952010 creator A5071458554 @default.
• W4308952010 creator A5075987263 @default.
• W4308952010 creator A5082140942 @default.
• W4308952010 date "2022-11-14" @default.
• W4308952010 modified "2023-09-28" @default.
• W4308952010 title "UBD is a potential diagnostic and prognostic biomarker in glioma" @default.
• W4308952010 cites W1946922646 @default.
• W4308952010 cites W1966107523 @default.
• W4308952010 cites W2005353940 @default.
• W4308952010 cites W2008982726 @default.
• W4308952010 cites W2013816626 @default.
• W4308952010 cites W2024630506 @default.
• W4308952010 cites W2035618305 @default.
• W4308952010 cites W2079879285 @default.
• W4308952010 cites W2115862526 @default.
• W4308952010 cites W2126817554 @default.
• W4308952010 cites W2130410032 @default.
• W4308952010 cites W2146470803 @default.
• W4308952010 cites W2159707944 @default.
• W4308952010 cites W2208641941 @default.
• W4308952010 cites W2296457333 @default.
• W4308952010 cites W2366536035 @default.
• W4308952010 cites W2566753678 @default.
• W4308952010 cites W2768591361 @default.
• W4308952010 cites W2804991195 @default.
• W4308952010 cites W2844479918 @default.
• W4308952010 cites W2928665623 @default.
• W4308952010 cites W2987124337 @default.
• W4308952010 cites W2997362479 @default.
• W4308952010 cites W3005468192 @default.
• W4308952010 cites W3008218521 @default.
• W4308952010 cites W3045208135 @default.
• W4308952010 cites W3180993552 @default.
• W4308952010 cites W3183019684 @default.
• W4308952010 cites W4210757594 @default.
• W4308952010 cites W4211105004 @default.
• W4308952010 cites W4296292810 @default.
• W4308952010 doi "https://doi.org/10.21203/rs.3.rs-2208671/v1" @default.
• W4308952010 hasPublicationYear "2022" @default.
• W4308952010 type Work @default.
• W4308952010 citedByCount "0" @default.
• W4308952010 crossrefType "posted-content" @default.
• W4308952010 hasAuthorship W4308952010A5014268033 @default.
• W4308952010 hasAuthorship W4308952010A5024818901 @default.
• W4308952010 hasAuthorship W4308952010A5043100976 @default.
• W4308952010 hasAuthorship W4308952010A5056202501 @default.
• W4308952010 hasAuthorship W4308952010A5069672266 @default.
• W4308952010 hasAuthorship W4308952010A5071458554 @default.
• W4308952010 hasAuthorship W4308952010A5075987263 @default.
• W4308952010 hasAuthorship W4308952010A5082140942 @default.
• W4308952010 hasBestOaLocation W43089520101 @default.
• W4308952010 hasConcept C104317684 @default.
• W4308952010 hasConcept C150194340 @default.
• W4308952010 hasConcept C152724338 @default.
• W4308952010 hasConcept C162317418 @default.
• W4308952010 hasConcept C2778227246 @default.
• W4308952010 hasConcept C502942594 @default.
• W4308952010 hasConcept C54355233 @default.
• W4308952010 hasConcept C62478195 @default.
• W4308952010 hasConcept C86554907 @default.
• W4308952010 hasConcept C86803240 @default.
• W4308952010 hasConceptScore W4308952010C104317684 @default.
• W4308952010 hasConceptScore W4308952010C150194340 @default.
• W4308952010 hasConceptScore W4308952010C152724338 @default.
• W4308952010 hasConceptScore W4308952010C162317418 @default.
• W4308952010 hasConceptScore W4308952010C2778227246 @default.
• W4308952010 hasConceptScore W4308952010C502942594 @default.
• W4308952010 hasConceptScore W4308952010C54355233 @default.
• W4308952010 hasConceptScore W4308952010C62478195 @default.
• W4308952010 hasConceptScore W4308952010C86554907 @default.
• W4308952010 hasConceptScore W4308952010C86803240 @default.
• W4308952010 hasLocation W43089520101 @default.
• W4308952010 hasOpenAccess W4308952010 @default.
• W4308952010 hasPrimaryLocation W43089520101 @default.
• W4308952010 hasRelatedWork W2363685873 @default.
• W4308952010 hasRelatedWork W2898495355 @default.
• W4308952010 hasRelatedWork W2947842923 @default.
• W4308952010 hasRelatedWork W3022564264 @default.
• W4308952010 hasRelatedWork W3146309432 @default.
• W4308952010 hasRelatedWork W3164029683 @default.
• W4308952010 hasRelatedWork W3197753362 @default.
• W4308952010 hasRelatedWork W3212504825 @default.
• W4308952010 hasRelatedWork W3216750786 @default.
• W4308952010 hasRelatedWork W4313427036 @default.
• W4308952010 isParatext "false" @default.
• W4308952010 isRetracted "false" @default.
• W4308952010 workType "article" @default.