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• W4308952243 abstract "Abstract α-Synuclein (α-Syn) is a natively unstructured protein, which self-assembles into higher-order aggregates possessing serious pathophysiological implications. α-Syn aberrantly self-assembles into protein aggregates, which have been widely implicated in Parkinson’s disease (PD) pathogenesis and other synucleinopathies. The self-assembly of α-Syn involves the structural conversion of soluble monomeric protein into oligomeric intermediates and eventually fibrillar aggregates of amyloids with cross-β-sheet rich conformation. These aggregated α-Syn species majorly constitute the intraneuronal inclusions, which is a hallmark of PD neuropathology. Self-assembly/aggregation of α-Syn is not a single-state conversion process as unfolded protein can access multiple conformational states through the formation of metastable, transient pre-fibrillar intermediate species. Recent studies have indicated that soluble oligomers are the potential neurotoxic species responsible for cell death in PD pathogenesis. The heterogeneous and transient nature of oligomers formed during the early stage of aggregation pathway limit their detailed study in understanding the structure–toxicity relationship. Moreover, the precise molecular events occurring in the early stage of α-Syn aggregation process majorly remain unsolved. Recently, liquid–liquid phase separation (LLPS) of α-Syn has been designated as an alternate nucleation mechanism, which occurs in the early lag phase of the aggregation pathway leading to the formation of dynamic supramolecular assemblies. The stronger self-association among the protein molecules triggers the irreversible liquid-to-solid transition of these supramolecular assemblies into the amyloid-like hydrogel, which may serve as a reservoir entrapping toxic oligomeric intermediates and fibrils. This review strives to provide insights into different modes of α-Syn self-assemblies including LLPS-mediated self-assembly and its recent advancements." @default.
• W4308952243 created "2022-11-20" @default.
• W4308952243 creator A5000183173 @default.
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• W4308952243 creator A5064780383 @default.
• W4308952243 creator A5066487445 @default.
• W4308952243 creator A5081041480 @default.
• W4308952243 date "2022-12-01" @default.
• W4308952243 modified "2023-10-14" @default.
• W4308952243 title "Phase separation and other forms of α-Synuclein self-assemblies" @default.
• W4308952243 cites W1508926134 @default.
• W4308952243 cites W1521854746 @default.
• W4308952243 cites W1527671059 @default.
• W4308952243 cites W1542222030 @default.
• W4308952243 cites W1680110353 @default.
• W4308952243 cites W1912455695 @default.
• W4308952243 cites W1952608303 @default.
• W4308952243 cites W1965888147 @default.
• W4308952243 cites W1979591162 @default.
• W4308952243 cites W1979786105 @default.
• W4308952243 cites W1985811626 @default.
• W4308952243 cites W1986625112 @default.
• W4308952243 cites W1990473626 @default.
• W4308952243 cites W1991241547 @default.
• W4308952243 cites W1995191747 @default.
• W4308952243 cites W1999221820 @default.
• W4308952243 cites W2001407922 @default.
• W4308952243 cites W2005622137 @default.
• W4308952243 cites W2009556855 @default.
• W4308952243 cites W2009573330 @default.
• W4308952243 cites W2013112316 @default.
• W4308952243 cites W2016875890 @default.
• W4308952243 cites W2018481846 @default.
• W4308952243 cites W2021977313 @default.
• W4308952243 cites W2026226960 @default.
• W4308952243 cites W2030325989 @default.
• W4308952243 cites W2031982078 @default.
• W4308952243 cites W2032487213 @default.
• W4308952243 cites W2036386995 @default.
• W4308952243 cites W2044407202 @default.
• W4308952243 cites W2046014998 @default.
• W4308952243 cites W2050786534 @default.
• W4308952243 cites W2052660967 @default.
• W4308952243 cites W2054352933 @default.
• W4308952243 cites W2054868321 @default.
• W4308952243 cites W2060085692 @default.
• W4308952243 cites W2068955183 @default.
• W4308952243 cites W2074649216 @default.
• W4308952243 cites W2075793841 @default.
• W4308952243 cites W2085978470 @default.
• W4308952243 cites W2087482196 @default.
• W4308952243 cites W2091214947 @default.
• W4308952243 cites W2101659873 @default.
• W4308952243 cites W2105488386 @default.
• W4308952243 cites W2107252117 @default.
• W4308952243 cites W2107434243 @default.
• W4308952243 cites W2111216320 @default.
• W4308952243 cites W2121852043 @default.
• W4308952243 cites W2128048423 @default.
• W4308952243 cites W2129583700 @default.
• W4308952243 cites W2136429865 @default.
• W4308952243 cites W2138070282 @default.
• W4308952243 cites W2139066576 @default.
• W4308952243 cites W2141852179 @default.
• W4308952243 cites W2145835162 @default.
• W4308952243 cites W2150860983 @default.
• W4308952243 cites W2152962886 @default.
• W4308952243 cites W2153429571 @default.
• W4308952243 cites W2158089391 @default.
• W4308952243 cites W2165186407 @default.
• W4308952243 cites W2166789153 @default.
• W4308952243 cites W2279088384 @default.
• W4308952243 cites W2307399619 @default.
• W4308952243 cites W2317462515 @default.
• W4308952243 cites W2501424458 @default.
• W4308952243 cites W2510545519 @default.
• W4308952243 cites W2514004327 @default.
• W4308952243 cites W2531051110 @default.
• W4308952243 cites W2548909731 @default.
• W4308952243 cites W2590568317 @default.
• W4308952243 cites W2593862218 @default.
• W4308952243 cites W2745164635 @default.
• W4308952243 cites W2751519328 @default.
• W4308952243 cites W2756821926 @default.
• W4308952243 cites W2765486298 @default.
• W4308952243 cites W2775514330 @default.
• W4308952243 cites W2782130029 @default.
• W4308952243 cites W2788827529 @default.
• W4308952243 cites W2791232057 @default.
• W4308952243 cites W2808551426 @default.
• W4308952243 cites W2817784260 @default.
• W4308952243 cites W2884160828 @default.
• W4308952243 cites W2889082939 @default.
• W4308952243 cites W2910314419 @default.
• W4308952243 cites W2914208030 @default.
• W4308952243 cites W2916646997 @default.
• W4308952243 cites W2921561422 @default.
• W4308952243 cites W2954385672 @default.

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