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- W4308954139 abstract "Abstract our study aims to explore the mechanism of astaxanthin (ASTA) supplementation on liver oxidative damage in rats induced by acute high-intensity exercise. 32 male SD rats were randomly separated into 4 groups: the control, exercise, administration, and exercise + administration. Group M and EM were treated with oil-soluble astaxanthin (25 mg/kg, every day) while group C and E were given an equal amount of soybean oil instead. The final acute high-intensity treadmill exercise was performed in group E and EM. All rats were sacrificed immediately after exercise, levels of plasma liver function indexes such as ALT and AST were assessed, and contents of MDA, SOD, and GSH were measured to reflect oxidative stress of the mice. Additionally, the relative expressions of mRNA and protein of the AMPK/Nrf2/HO-1 pathway in rats’ livers were also determined. According to the results of indicators assessment in our study, we found acute high-intensity exercise could induce liver damage, however, ASTA intervention will decrease ALT levels, reduce MDA concentration, as well as increase SOD activities and p-GSK-3β expression significantly to alleviate exercise-induced injuries in rats. Furthermore, ASTA also upregulates the expression of the AMPK/Nrf2 signal pathway by increasing AMPKα1 phosphorylation and activating the transcription factor Nrf2 to enhance the transcriptional translation of downstream HO-1 protein which could improve antioxidant capacity and repair exercise-induced oxidative damage. This research illustrated an unexplored effect of ASTA that it was useful in the therapy of exercise-induced liver injury through the regulation of the AMPK/Nrf2/HO-1-mediated antioxidant pathway but inhibited HO-1 expression in quiet rats." @default.
- W4308954139 created "2022-11-20" @default.
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- W4308954139 date "2022-11-14" @default.
- W4308954139 modified "2023-09-25" @default.
- W4308954139 title "Effects of astaxanthin and acute high-intensity exercise on liver oxidative stress in rats" @default.
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- W4308954139 doi "https://doi.org/10.21203/rs.3.rs-2217533/v1" @default.
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