Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308954904> ?p ?o ?g. }
- W4308954904 endingPage "300" @default.
- W4308954904 startingPage "294" @default.
- W4308954904 abstract "The integrity and function of catecholamine neurotransmitter systems can be assessed using neuromelanin-sensitive MRI (NM-MRI). The relevance of this method to neurodegenerative and psychiatric disorders is becoming increasingly evident, and it has potential as a clinical biomarker.To support future application of NM-MRI as a clinical biomarker by defining the normative range of NM-MRI signal and volume metrics in cognitively normal older adults.Prospective.A total of 152 cognitively normal older adults aged 53-86 years old, including 41 participants who had follow-up NM-MRI data collected 9-16 months later.A 3.0 T; NM-MRI turbo spin echo and T1-weighted magnetization-prepared rapid acquisition with gradient echo sequences.NM-MRI images were processed to yield summary measures of volume and signal (contrast-to-noise ratio, CNR) for the substantia nigra (SN) and locus coeruleus (LC) using a recently developed software employing a fully automated algorithm. Change in these metrics over time was also assessed.Mean and standard deviation of NM-MRI metrics were calculated; change over time was tested for significance using 1-sample t-tests. P values < 0.05 were considered statistically significant.At baseline SN signal (CNR) was 10.02% (left) and 10.28% (right) and LC signal was 24.71% (left) and 20.42% (right). Baseline SN volume was 576 mm3 (left) and 540 mm3 (right) and LC volume was 6.31 mm3 (left) and 6.30 mm3 (right). The only NM-MRI metric showing significant change was a decrease in left SN volume (t40 = -2.57, P = 0.014).We report normative values for NM-MRI signal and volume in the SN and LC of cognitively normal older adults and explore their change over time. These values may help future efforts to use NM-MRI as a clinical biomarker by facilitating identification of patients with extreme NM-MRI values.1." @default.
- W4308954904 created "2022-11-20" @default.
- W4308954904 creator A5008077492 @default.
- W4308954904 creator A5015553503 @default.
- W4308954904 creator A5038765642 @default.
- W4308954904 creator A5055811550 @default.
- W4308954904 creator A5070132400 @default.
- W4308954904 creator A5081706478 @default.
- W4308954904 creator A5091097481 @default.
- W4308954904 date "2022-11-14" @default.
- W4308954904 modified "2023-10-16" @default.
- W4308954904 title "Normative Values of Neuromelanin‐Sensitive <scp>MRI</scp> Signal in Older Adults Obtained Using a Turbo Spin Echo Sequence" @default.
- W4308954904 cites W1964380204 @default.
- W4308954904 cites W1974146533 @default.
- W4308954904 cites W2032587951 @default.
- W4308954904 cites W2058514758 @default.
- W4308954904 cites W2073760242 @default.
- W4308954904 cites W2086361121 @default.
- W4308954904 cites W2134237347 @default.
- W4308954904 cites W2537916692 @default.
- W4308954904 cites W2567419629 @default.
- W4308954904 cites W2767880113 @default.
- W4308954904 cites W2797850641 @default.
- W4308954904 cites W2809129539 @default.
- W4308954904 cites W2897780572 @default.
- W4308954904 cites W2900464582 @default.
- W4308954904 cites W2915476106 @default.
- W4308954904 cites W2919982464 @default.
- W4308954904 cites W2956068311 @default.
- W4308954904 cites W2972368830 @default.
- W4308954904 cites W2995135001 @default.
- W4308954904 cites W3008786370 @default.
- W4308954904 cites W3022343867 @default.
- W4308954904 cites W3024975136 @default.
- W4308954904 cites W3085930259 @default.
- W4308954904 cites W3091907834 @default.
- W4308954904 cites W3094510370 @default.
- W4308954904 cites W3108328514 @default.
- W4308954904 cites W3111433669 @default.
- W4308954904 cites W3127817949 @default.
- W4308954904 cites W3159770446 @default.
- W4308954904 cites W3161529151 @default.
- W4308954904 cites W3172899218 @default.
- W4308954904 cites W3209443718 @default.
- W4308954904 cites W4212983870 @default.
- W4308954904 doi "https://doi.org/10.1002/jmri.28530" @default.
- W4308954904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36373996" @default.
- W4308954904 hasPublicationYear "2022" @default.
- W4308954904 type Work @default.
- W4308954904 citedByCount "0" @default.
- W4308954904 crossrefType "journal-article" @default.
- W4308954904 hasAuthorship W4308954904A5008077492 @default.
- W4308954904 hasAuthorship W4308954904A5015553503 @default.
- W4308954904 hasAuthorship W4308954904A5038765642 @default.
- W4308954904 hasAuthorship W4308954904A5055811550 @default.
- W4308954904 hasAuthorship W4308954904A5070132400 @default.
- W4308954904 hasAuthorship W4308954904A5081706478 @default.
- W4308954904 hasAuthorship W4308954904A5091097481 @default.
- W4308954904 hasConcept C121332964 @default.
- W4308954904 hasConcept C126322002 @default.
- W4308954904 hasConcept C126838900 @default.
- W4308954904 hasConcept C137183658 @default.
- W4308954904 hasConcept C143409427 @default.
- W4308954904 hasConcept C185592680 @default.
- W4308954904 hasConcept C2780938664 @default.
- W4308954904 hasConcept C2781197716 @default.
- W4308954904 hasConcept C2989005 @default.
- W4308954904 hasConcept C43310041 @default.
- W4308954904 hasConcept C46141821 @default.
- W4308954904 hasConcept C513476851 @default.
- W4308954904 hasConcept C55493867 @default.
- W4308954904 hasConcept C71924100 @default.
- W4308954904 hasConceptScore W4308954904C121332964 @default.
- W4308954904 hasConceptScore W4308954904C126322002 @default.
- W4308954904 hasConceptScore W4308954904C126838900 @default.
- W4308954904 hasConceptScore W4308954904C137183658 @default.
- W4308954904 hasConceptScore W4308954904C143409427 @default.
- W4308954904 hasConceptScore W4308954904C185592680 @default.
- W4308954904 hasConceptScore W4308954904C2780938664 @default.
- W4308954904 hasConceptScore W4308954904C2781197716 @default.
- W4308954904 hasConceptScore W4308954904C2989005 @default.
- W4308954904 hasConceptScore W4308954904C43310041 @default.
- W4308954904 hasConceptScore W4308954904C46141821 @default.
- W4308954904 hasConceptScore W4308954904C513476851 @default.
- W4308954904 hasConceptScore W4308954904C55493867 @default.
- W4308954904 hasConceptScore W4308954904C71924100 @default.
- W4308954904 hasFunder F4320306219 @default.
- W4308954904 hasFunder F4320313565 @default.
- W4308954904 hasFunder F4320315912 @default.
- W4308954904 hasFunder F4320319952 @default.
- W4308954904 hasFunder F4320334593 @default.
- W4308954904 hasIssue "1" @default.
- W4308954904 hasLocation W43089549041 @default.
- W4308954904 hasLocation W43089549042 @default.
- W4308954904 hasOpenAccess W4308954904 @default.
- W4308954904 hasPrimaryLocation W43089549041 @default.
- W4308954904 hasRelatedWork W1558984540 @default.
- W4308954904 hasRelatedWork W1601438958 @default.