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- W4308957055 abstract "Necroptosis is a type of precisely regulated necrotic cell death activated in caspase-deficient conditions. Multiple factors initiate the necroptotic signaling pathway, including toll-like receptor 3/4, tumor necrosis factor (TNF), dsRNA viruses, and T cell receptors. Presently, TNF-induced necroptosis via the phosphorylation of three key proteins, receptor-interacting protein kinase 1, receptor-interacting protein kinase 3, and mixed lineage kinase domain-like protein, is the best-characterized process. Necroptosis induced by Z-DNA-binding protein 1 (ZBP-1) and toll/interleukin-1 receptor (TIR)-domain-containing adapter-inducing interferon (TRIF) plays a significant role in infectious diseases, such as influenza A virus, Zika virus, and herpesvirus infection. An increasing number of studies have demonstrated the close association of necroptosis with multiple diseases, and disrupting necroptosis has been confirmed to be effective for treating (or managing) these diseases. The central nervous system (CNS) exhibits unique physiological structures and immune characteristics. Necroptosis may occur without the sequential activation of signal proteins, and the necroptosis of supporting cells has more important implications in disease development. Additionally, necroptotic signals can be activated in the absence of necroptosis. Here, we summarize the role of necroptosis and its signal proteins in CNS diseases and characterize typical necroptosis regulators to provide a basis for the further development of therapeutic strategies for treating such diseases. In the present review, relevant information has been consolidated from recent studies (from 2010 until the present), excluding the patents in this field." @default.
- W4308957055 created "2022-11-20" @default.
- W4308957055 creator A5001631388 @default.
- W4308957055 creator A5021152939 @default.
- W4308957055 creator A5051368106 @default.
- W4308957055 creator A5081109406 @default.
- W4308957055 creator A5089893818 @default.
- W4308957055 date "2022-11-14" @default.
- W4308957055 modified "2023-10-18" @default.
- W4308957055 title "Role of Necroptosis in Central Nervous System Diseases" @default.
- W4308957055 cites W1572639874 @default.
- W4308957055 cites W1832463541 @default.
- W4308957055 cites W1840705951 @default.
- W4308957055 cites W1910257954 @default.
- W4308957055 cites W1966977448 @default.
- W4308957055 cites W1968051713 @default.
- W4308957055 cites W1971182364 @default.
- W4308957055 cites W1972784467 @default.
- W4308957055 cites W1974508320 @default.
- W4308957055 cites W1983151602 @default.
- W4308957055 cites W1985831101 @default.
- W4308957055 cites W1986283558 @default.
- W4308957055 cites W2001153857 @default.
- W4308957055 cites W2007303185 @default.
- W4308957055 cites W2009958847 @default.
- W4308957055 cites W2011440382 @default.
- W4308957055 cites W2017367722 @default.
- W4308957055 cites W2023122823 @default.
- W4308957055 cites W2025954620 @default.
- W4308957055 cites W2030194678 @default.
- W4308957055 cites W2034678563 @default.
- W4308957055 cites W2039254613 @default.
- W4308957055 cites W2040709788 @default.
- W4308957055 cites W2046864536 @default.
- W4308957055 cites W2058824573 @default.
- W4308957055 cites W2060439319 @default.
- W4308957055 cites W2065472817 @default.
- W4308957055 cites W2071769633 @default.
- W4308957055 cites W2076628448 @default.
- W4308957055 cites W2076658768 @default.
- W4308957055 cites W2084414744 @default.
- W4308957055 cites W2084839197 @default.
- W4308957055 cites W2091263717 @default.
- W4308957055 cites W2091363184 @default.
- W4308957055 cites W2091603938 @default.
- W4308957055 cites W2106313322 @default.
- W4308957055 cites W2110796758 @default.
- W4308957055 cites W2112161237 @default.
- W4308957055 cites W2114445825 @default.
- W4308957055 cites W2117692326 @default.
- W4308957055 cites W2123301364 @default.
- W4308957055 cites W2123504406 @default.
- W4308957055 cites W2127089219 @default.
- W4308957055 cites W2132161879 @default.
- W4308957055 cites W2138671479 @default.
- W4308957055 cites W2156606243 @default.
- W4308957055 cites W2158695265 @default.
- W4308957055 cites W2164482565 @default.
- W4308957055 cites W2169820248 @default.
- W4308957055 cites W2290683813 @default.
- W4308957055 cites W2317875558 @default.
- W4308957055 cites W2328275151 @default.
- W4308957055 cites W2429745182 @default.
- W4308957055 cites W2467178923 @default.
- W4308957055 cites W2512250682 @default.
- W4308957055 cites W2530130883 @default.
- W4308957055 cites W2551139545 @default.
- W4308957055 cites W2583964565 @default.
- W4308957055 cites W2592638716 @default.
- W4308957055 cites W2593130667 @default.
- W4308957055 cites W2594120765 @default.
- W4308957055 cites W2594466126 @default.
- W4308957055 cites W2600098707 @default.
- W4308957055 cites W2622433887 @default.
- W4308957055 cites W2732044567 @default.
- W4308957055 cites W2736148366 @default.
- W4308957055 cites W2745482791 @default.
- W4308957055 cites W2768828610 @default.
- W4308957055 cites W2773003990 @default.
- W4308957055 cites W2782643375 @default.
- W4308957055 cites W2786608785 @default.
- W4308957055 cites W2788200071 @default.
- W4308957055 cites W2789098190 @default.
- W4308957055 cites W2793520298 @default.
- W4308957055 cites W2794531648 @default.
- W4308957055 cites W2883399815 @default.
- W4308957055 cites W2885021343 @default.
- W4308957055 cites W2885612978 @default.
- W4308957055 cites W2885643008 @default.
- W4308957055 cites W2886848193 @default.
- W4308957055 cites W2891150481 @default.
- W4308957055 cites W2892884172 @default.
- W4308957055 cites W2899745584 @default.
- W4308957055 cites W2900592617 @default.
- W4308957055 cites W2901090149 @default.
- W4308957055 cites W2901410206 @default.
- W4308957055 cites W2901591673 @default.
- W4308957055 cites W2903134099 @default.