Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308959560> ?p ?o ?g. }
- W4308959560 abstract "Pathogens utilize a panoply of effectors to manipulate plant defense. However, despite their importance, relatively little is actually known about regulation of these virulence factors. Here, we show that the effector Fol-Secreted Virulence-related Protein1 (FolSvp1), secreted from fungal pathogen Fusarium oxysporum f. sp. lycopersici (Fol), directly binds and translocates the tomato pathogenesis-related protein1, SlPR1, from the apoplast outside the plasma membrane to the host nucleus via its nuclear localization signal. Relocation of SlPR1 abolishes generation of the defense signaling peptide, CAPE1, from its C-terminus, and as a consequence, facilitates pathogen invasion of plants. The action of FolSvp1 requires covalent modification by acetylation for full virulence in host tomato tissues. The modification is catalyzed by the Fol FolArd1 lysine acetyltransferase prior to secretion. Addition of an acetyl group to one residue, K167, prevents ubiquitination-dependent degradation of FolSvp1 in both Fol and plant cells with different mechanisms, allowing it to function normally in fungal invasion. Either inactivation of FolSvp1 or removal of the acetyl group on K167 leads to impaired pathogenicity of Fol. These findings indicate that acetylation can regulate the stability of effectors of fungal plant pathogens with impact on virulence." @default.
- W4308959560 created "2022-11-20" @default.
- W4308959560 creator A5015059243 @default.
- W4308959560 creator A5017489937 @default.
- W4308959560 creator A5029535089 @default.
- W4308959560 creator A5030054664 @default.
- W4308959560 creator A5050944289 @default.
- W4308959560 creator A5065682380 @default.
- W4308959560 creator A5066252438 @default.
- W4308959560 creator A5073430885 @default.
- W4308959560 creator A5073682823 @default.
- W4308959560 creator A5076374841 @default.
- W4308959560 creator A5087078289 @default.
- W4308959560 date "2022-11-14" @default.
- W4308959560 modified "2023-10-04" @default.
- W4308959560 title "Acetylation of a fungal effector that translocates host PR1 facilitates virulence" @default.
- W4308959560 cites W1932563084 @default.
- W4308959560 cites W1976479962 @default.
- W4308959560 cites W1976572901 @default.
- W4308959560 cites W1979751618 @default.
- W4308959560 cites W1980400357 @default.
- W4308959560 cites W1999704088 @default.
- W4308959560 cites W2003847336 @default.
- W4308959560 cites W2043968267 @default.
- W4308959560 cites W2050352895 @default.
- W4308959560 cites W2057027106 @default.
- W4308959560 cites W2060021093 @default.
- W4308959560 cites W2060687391 @default.
- W4308959560 cites W2067327084 @default.
- W4308959560 cites W2077629516 @default.
- W4308959560 cites W2083786731 @default.
- W4308959560 cites W2089924560 @default.
- W4308959560 cites W2099709293 @default.
- W4308959560 cites W2102967742 @default.
- W4308959560 cites W2109787886 @default.
- W4308959560 cites W2111666158 @default.
- W4308959560 cites W2113030015 @default.
- W4308959560 cites W2120352541 @default.
- W4308959560 cites W2121711582 @default.
- W4308959560 cites W2123762144 @default.
- W4308959560 cites W2125796073 @default.
- W4308959560 cites W2136150719 @default.
- W4308959560 cites W2136277259 @default.
- W4308959560 cites W2151138136 @default.
- W4308959560 cites W2151456886 @default.
- W4308959560 cites W2156135421 @default.
- W4308959560 cites W2157009395 @default.
- W4308959560 cites W2158574346 @default.
- W4308959560 cites W2162593910 @default.
- W4308959560 cites W2171468101 @default.
- W4308959560 cites W2271589648 @default.
- W4308959560 cites W2418751601 @default.
- W4308959560 cites W2462442932 @default.
- W4308959560 cites W2463509995 @default.
- W4308959560 cites W2531786333 @default.
- W4308959560 cites W2566099566 @default.
- W4308959560 cites W2566590848 @default.
- W4308959560 cites W2608973317 @default.
- W4308959560 cites W2737271408 @default.
- W4308959560 cites W2767852758 @default.
- W4308959560 cites W2772769731 @default.
- W4308959560 cites W2788119140 @default.
- W4308959560 cites W2800657447 @default.
- W4308959560 cites W2895994045 @default.
- W4308959560 cites W2901164269 @default.
- W4308959560 cites W2904681346 @default.
- W4308959560 cites W2913664350 @default.
- W4308959560 cites W2947179950 @default.
- W4308959560 cites W2947365602 @default.
- W4308959560 cites W2985043365 @default.
- W4308959560 cites W3033601502 @default.
- W4308959560 cites W3081060139 @default.
- W4308959560 cites W3083467890 @default.
- W4308959560 cites W3083776579 @default.
- W4308959560 cites W3084084697 @default.
- W4308959560 cites W3110038919 @default.
- W4308959560 cites W3126941951 @default.
- W4308959560 cites W3159852584 @default.
- W4308959560 cites W4226056799 @default.
- W4308959560 cites W4251635246 @default.
- W4308959560 doi "https://doi.org/10.7554/elife.82628" @default.
- W4308959560 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36374166" @default.
- W4308959560 hasPublicationYear "2022" @default.
- W4308959560 type Work @default.
- W4308959560 citedByCount "7" @default.
- W4308959560 countsByYear W43089595602023 @default.
- W4308959560 crossrefType "journal-article" @default.
- W4308959560 hasAuthorship W4308959560A5015059243 @default.
- W4308959560 hasAuthorship W4308959560A5017489937 @default.
- W4308959560 hasAuthorship W4308959560A5029535089 @default.
- W4308959560 hasAuthorship W4308959560A5030054664 @default.
- W4308959560 hasAuthorship W4308959560A5050944289 @default.
- W4308959560 hasAuthorship W4308959560A5065682380 @default.
- W4308959560 hasAuthorship W4308959560A5066252438 @default.
- W4308959560 hasAuthorship W4308959560A5073430885 @default.
- W4308959560 hasAuthorship W4308959560A5073682823 @default.
- W4308959560 hasAuthorship W4308959560A5076374841 @default.
- W4308959560 hasAuthorship W4308959560A5087078289 @default.
- W4308959560 hasBestOaLocation W43089595601 @default.
- W4308959560 hasConcept C104317684 @default.