Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308961920> ?p ?o ?g. }
- W4308961920 abstract "Abstract As medical research has progressed, the derivation and development of biological materials such as hydrogels have steadily gained more interest. The biocompatibility and non-toxicity of chitosan make chitosan hydrogels potential carriers for drug delivery. This work aims to develop two multi-reactive, safe and highly swellable bio-hydrogels consisting of chitosan-graft-glycerol (CS-g-gly) and carboxymethyl chitosan-graft-glycerol (CMCS-g-gly), for sustained and controlled drug release, improved bioavailability along with entrapment in nanocarriers, which reduces side effects of vincristine sulphate. CS-g-gly and CMCS-g-gly were successfully prepared and fully characterized using FT-IR, 1HNMR, FE-SEM, AFM, TGA, DLS, and zeta potential techniques. Under various conditions, the prepared hydrogels exhibited a high swelling ratio. Vincristine loaded CS-g-gly (VCR/CS-g-gly) and CMCS-g-gly (VCR/CMCS-g-gly) showed high encapsulation efficiency between 72.28–89.97%, and 56.97–71.91%, respectively. VCR/CS-g-gly showed a sustained release behavior, and the maximum release of VCR from hydrogels reached 82% after 120 h of incubation. MCF-7 and MCF-10 cells were evaluated for cell viability and apoptosis induction. The in-vitro anti-tumor efficacy was investigated using flow cytometry. MTT analysis of hydrogels showed no evidence of significant cytotoxicity in MCF-7 and MCF-10 cells. According to these findings, these hydrogels could effectively deliver drugs to MCF-7 and other breast cancer cells." @default.
- W4308961920 created "2022-11-20" @default.
- W4308961920 creator A5031312992 @default.
- W4308961920 creator A5056351005 @default.
- W4308961920 creator A5077579295 @default.
- W4308961920 creator A5077817757 @default.
- W4308961920 date "2022-11-15" @default.
- W4308961920 modified "2023-09-26" @default.
- W4308961920 title "Multi-Responsive Chitosan-Based Hydrogels for Controlled Release of Vincristine: Design, Characterization, and Safety Evaluation" @default.
- W4308961920 cites W1539083544 @default.
- W4308961920 cites W1752299999 @default.
- W4308961920 cites W1901198588 @default.
- W4308961920 cites W1963878289 @default.
- W4308961920 cites W1965381824 @default.
- W4308961920 cites W1967037744 @default.
- W4308961920 cites W1977072597 @default.
- W4308961920 cites W1990243608 @default.
- W4308961920 cites W1997401706 @default.
- W4308961920 cites W2004457388 @default.
- W4308961920 cites W2007684516 @default.
- W4308961920 cites W2010179884 @default.
- W4308961920 cites W2024539092 @default.
- W4308961920 cites W2034094119 @default.
- W4308961920 cites W2040448941 @default.
- W4308961920 cites W2048641553 @default.
- W4308961920 cites W2051350672 @default.
- W4308961920 cites W2055402663 @default.
- W4308961920 cites W2059803951 @default.
- W4308961920 cites W2062238282 @default.
- W4308961920 cites W2075216419 @default.
- W4308961920 cites W2077939789 @default.
- W4308961920 cites W2079757899 @default.
- W4308961920 cites W2085133554 @default.
- W4308961920 cites W2086130473 @default.
- W4308961920 cites W2087960143 @default.
- W4308961920 cites W2115183689 @default.
- W4308961920 cites W2116697593 @default.
- W4308961920 cites W2119942076 @default.
- W4308961920 cites W2132261625 @default.
- W4308961920 cites W2166938624 @default.
- W4308961920 cites W2270008543 @default.
- W4308961920 cites W2282646071 @default.
- W4308961920 cites W2332252655 @default.
- W4308961920 cites W2487355051 @default.
- W4308961920 cites W2519000420 @default.
- W4308961920 cites W2538084122 @default.
- W4308961920 cites W2552047904 @default.
- W4308961920 cites W2566415674 @default.
- W4308961920 cites W2577243541 @default.
- W4308961920 cites W2595989345 @default.
- W4308961920 cites W2752826782 @default.
- W4308961920 cites W2763173089 @default.
- W4308961920 cites W2766744214 @default.
- W4308961920 cites W2770837948 @default.
- W4308961920 cites W2794612623 @default.
- W4308961920 cites W2795360731 @default.
- W4308961920 cites W2799314544 @default.
- W4308961920 cites W2804846127 @default.
- W4308961920 cites W2807424937 @default.
- W4308961920 cites W2811465773 @default.
- W4308961920 cites W2884165971 @default.
- W4308961920 cites W2908113810 @default.
- W4308961920 cites W2961954155 @default.
- W4308961920 cites W2984274639 @default.
- W4308961920 cites W2995752595 @default.
- W4308961920 cites W3023921650 @default.
- W4308961920 cites W3031197103 @default.
- W4308961920 cites W3086933766 @default.
- W4308961920 cites W3093223611 @default.
- W4308961920 cites W3112694861 @default.
- W4308961920 cites W3131913208 @default.
- W4308961920 cites W3157267564 @default.
- W4308961920 cites W3166201125 @default.
- W4308961920 cites W3205895795 @default.
- W4308961920 cites W4200170237 @default.
- W4308961920 cites W4200415982 @default.
- W4308961920 cites W4200625707 @default.
- W4308961920 cites W4211070775 @default.
- W4308961920 cites W4223571323 @default.
- W4308961920 cites W4232873228 @default.
- W4308961920 cites W4283645909 @default.
- W4308961920 cites W950508456 @default.
- W4308961920 doi "https://doi.org/10.21203/rs.3.rs-2214157/v1" @default.
- W4308961920 hasPublicationYear "2022" @default.
- W4308961920 type Work @default.
- W4308961920 citedByCount "0" @default.
- W4308961920 crossrefType "posted-content" @default.
- W4308961920 hasAuthorship W4308961920A5031312992 @default.
- W4308961920 hasAuthorship W4308961920A5056351005 @default.
- W4308961920 hasAuthorship W4308961920A5077579295 @default.
- W4308961920 hasAuthorship W4308961920A5077817757 @default.
- W4308961920 hasBestOaLocation W43089619201 @default.
- W4308961920 hasConcept C108586683 @default.
- W4308961920 hasConcept C109316439 @default.
- W4308961920 hasConcept C13965031 @default.
- W4308961920 hasConcept C155672457 @default.
- W4308961920 hasConcept C159985019 @default.
- W4308961920 hasConcept C171250308 @default.
- W4308961920 hasConcept C178790620 @default.
- W4308961920 hasConcept C181389837 @default.