FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308964091> ?p ?o ?g. }

• W4308964091 endingPage "e0274598" @default.
• W4308964091 startingPage "e0274598" @default.
• W4308964091 abstract "Introduction Primary focal segmental glomerulosclerosis (FSGS), a major cause of end-stage kidney disease (ESKD) in adolescents and young adults, is attributable to recognized genetic mutations in a minority of cases. For the majority with idiopathic primary FSGS, the cause of the disease is unknown. We hypothesize that extracellular vesicle (EVs), that carry information between podocytes and mesangial cells, may play a key role in disease progression. Material & methods A total of 30 participants (20 primary nephrotic syndrome/ 10 healthy controls) were enrolled in this study. Primary nephrotic syndrome subjects were grouped based on pathologic diagnosis. The FSGS group was compared to healthy control subjects based on demographic and clinical findings. EVs were isolated from the urine of each group before being characterized by Western blotting, transmission electron microscopy, and nanoparticle tracking analysis. The effects of the EVs from each group on normal human mesangial cells and activation of certain pathways were then investigated. Results Based on demographic and clinical findings, mean serum creatinine was significantly higher in the FSGS group than the normal healthy control group. The mean size of the EVs in the FSGS group was significantly higher than the healthy control group. The mesangial cells that were challenged with EVs isolated from FSGS patients showed significant upregulation of STAT-3, PCNA, Ki67, and cell proliferation. Discussion Our data demonstrate that EVs from FSGS patients stimulate mesangial cell proliferation in association with upregulation of the phospho-STAT-3 pathway. Additional studies are planned to identify the molecular cargo within the EVs from FSGS patients that contribute to the pathogenesis of FSGS." @default.
• W4308964091 created "2022-11-20" @default.
• W4308964091 creator A5007242435 @default.
• W4308964091 creator A5026771942 @default.
• W4308964091 creator A5043858832 @default.
• W4308964091 creator A5063041001 @default.
• W4308964091 creator A5063914529 @default.
• W4308964091 date "2022-11-14" @default.
• W4308964091 modified "2023-10-05" @default.
• W4308964091 title "Extracellular vesicles from focal segmental glomerulosclerosis pediatric patients induce STAT3 activation and mesangial cell proliferation" @default.
• W4308964091 cites W14066135 @default.
• W4308964091 cites W151785074 @default.
• W4308964091 cites W1966669762 @default.
• W4308964091 cites W1971356923 @default.
• W4308964091 cites W1973071106 @default.
• W4308964091 cites W1978564046 @default.
• W4308964091 cites W1983166456 @default.
• W4308964091 cites W1987294439 @default.
• W4308964091 cites W1991147271 @default.
• W4308964091 cites W1998532633 @default.
• W4308964091 cites W1998996047 @default.
• W4308964091 cites W2003343932 @default.
• W4308964091 cites W2005822625 @default.
• W4308964091 cites W2008348389 @default.
• W4308964091 cites W2029493112 @default.
• W4308964091 cites W2034238925 @default.
• W4308964091 cites W2047876945 @default.
• W4308964091 cites W2064621895 @default.
• W4308964091 cites W2070190142 @default.
• W4308964091 cites W2078776487 @default.
• W4308964091 cites W2094884742 @default.
• W4308964091 cites W2108375854 @default.
• W4308964091 cites W2121908444 @default.
• W4308964091 cites W2134052958 @default.
• W4308964091 cites W2136347227 @default.
• W4308964091 cites W2151098851 @default.
• W4308964091 cites W2152728073 @default.
• W4308964091 cites W2155876350 @default.
• W4308964091 cites W2242885831 @default.
• W4308964091 cites W2319345553 @default.
• W4308964091 cites W2330004628 @default.
• W4308964091 cites W2336590701 @default.
• W4308964091 cites W2406151998 @default.
• W4308964091 cites W2523917817 @default.
• W4308964091 cites W2582505124 @default.
• W4308964091 cites W2587360776 @default.
• W4308964091 cites W2591658560 @default.
• W4308964091 cites W2593771998 @default.
• W4308964091 cites W2749238253 @default.
• W4308964091 cites W2753839810 @default.
• W4308964091 cites W2765280408 @default.
• W4308964091 cites W2765358245 @default.
• W4308964091 cites W2886500019 @default.
• W4308964091 cites W2889262735 @default.
• W4308964091 cites W2922144466 @default.
• W4308964091 cites W2926512122 @default.
• W4308964091 cites W2962176767 @default.
• W4308964091 cites W2974882136 @default.
• W4308964091 cites W3019966725 @default.
• W4308964091 cites W3081422943 @default.
• W4308964091 cites W3128365310 @default.
• W4308964091 cites W4212860823 @default.
• W4308964091 cites W4249614921 @default.
• W4308964091 cites W4249713142 @default.
• W4308964091 doi "https://doi.org/10.1371/journal.pone.0274598" @default.
• W4308964091 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36374911" @default.
• W4308964091 hasPublicationYear "2022" @default.
• W4308964091 type Work @default.
• W4308964091 citedByCount "7" @default.
• W4308964091 countsByYear W43089640912023 @default.
• W4308964091 crossrefType "journal-article" @default.
• W4308964091 hasAuthorship W4308964091A5007242435 @default.
• W4308964091 hasAuthorship W4308964091A5026771942 @default.
• W4308964091 hasAuthorship W4308964091A5043858832 @default.
• W4308964091 hasAuthorship W4308964091A5063041001 @default.
• W4308964091 hasAuthorship W4308964091A5063914529 @default.
• W4308964091 hasBestOaLocation W43089640911 @default.
• W4308964091 hasConcept C126322002 @default.
• W4308964091 hasConcept C134018914 @default.
• W4308964091 hasConcept C203014093 @default.
• W4308964091 hasConcept C2777146197 @default.
• W4308964091 hasConcept C2777390665 @default.
• W4308964091 hasConcept C2777747828 @default.
• W4308964091 hasConcept C2778415529 @default.
• W4308964091 hasConcept C2778930706 @default.
• W4308964091 hasConcept C2779131090 @default.
• W4308964091 hasConcept C2779561371 @default.
• W4308964091 hasConcept C2780091579 @default.
• W4308964091 hasConcept C2780368995 @default.
• W4308964091 hasConcept C2780688133 @default.
• W4308964091 hasConcept C71924100 @default.
• W4308964091 hasConceptScore W4308964091C126322002 @default.
• W4308964091 hasConceptScore W4308964091C134018914 @default.
• W4308964091 hasConceptScore W4308964091C203014093 @default.
• W4308964091 hasConceptScore W4308964091C2777146197 @default.
• W4308964091 hasConceptScore W4308964091C2777390665 @default.
• W4308964091 hasConceptScore W4308964091C2777747828 @default.
• W4308964091 hasConceptScore W4308964091C2778415529 @default.

• next