Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308968501> ?p ?o ?g. }
- W4308968501 abstract "CD4 T cell-dependent IFNγ production and antibody are the two best known effectors for protective immunity against Chlamydia female reproductive tract (FRT) infection. Nevertheless, mice lacking either IFNγ or B cells can clear the vast majority of Chlamydia from the FRT, while suffering from varying degrees of disseminated infection. In this study, we investigated whether IFNγ and B cells play complementary roles in host defense against Chlamydia and evaluated their relative contributions in systemic and mucosal tissues. Using mice deficient in both IFNγ and B cells (IFNγ-/- x μMT), we showed that mice lacking both effectors were highly susceptible to lethal systemic bacterial dissemination following Chlamydia muridarum intravaginal infection. Passive transfer of immune convalescent serum, but not recombinant IFNγ, reduced bacterial burden in both systemic and mucosal tissues in IFNγ-/- x μMT mice. Notably, over the course of primary infection, we observed a reduction of bacterial shedding of more than 2 orders of magnitude in IFNγ-/- x μMT mice following both C. muridarum and C. trachomatis FRT infections. In contrast, no protective immunity against C. muridarum reinfection was detected in the absence of IFNγ and B cells. Together, our results suggest that IFNγ and B cells synergize to combat systemic Chlamydia dissemination, while additional IFNγ and B cell-independent mechanisms exist for host resistance to Chlamydia in the lower FRT." @default.
- W4308968501 created "2022-11-20" @default.
- W4308968501 creator A5003508150 @default.
- W4308968501 creator A5009792917 @default.
- W4308968501 creator A5027671539 @default.
- W4308968501 creator A5048455792 @default.
- W4308968501 creator A5048923360 @default.
- W4308968501 date "2022-12-15" @default.
- W4308968501 modified "2023-10-08" @default.
- W4308968501 title "IFNγ and Antibody Synergize To Enhance Protective Immunity against Chlamydia Dissemination and Female Reproductive Tract Reinfections" @default.
- W4308968501 cites W1489855050 @default.
- W4308968501 cites W1517495514 @default.
- W4308968501 cites W1526491561 @default.
- W4308968501 cites W1840348515 @default.
- W4308968501 cites W1893633247 @default.
- W4308968501 cites W1988208510 @default.
- W4308968501 cites W2005428616 @default.
- W4308968501 cites W2025656083 @default.
- W4308968501 cites W2084035178 @default.
- W4308968501 cites W2097021177 @default.
- W4308968501 cites W2101194050 @default.
- W4308968501 cites W2101851968 @default.
- W4308968501 cites W2102801418 @default.
- W4308968501 cites W2109648403 @default.
- W4308968501 cites W2123976777 @default.
- W4308968501 cites W2126465156 @default.
- W4308968501 cites W2136906333 @default.
- W4308968501 cites W2153418705 @default.
- W4308968501 cites W2158890206 @default.
- W4308968501 cites W2161356536 @default.
- W4308968501 cites W2162624157 @default.
- W4308968501 cites W2164567662 @default.
- W4308968501 cites W2164713036 @default.
- W4308968501 cites W2168352947 @default.
- W4308968501 cites W2316768044 @default.
- W4308968501 cites W2536866515 @default.
- W4308968501 cites W2737014988 @default.
- W4308968501 cites W2887857161 @default.
- W4308968501 cites W2916417447 @default.
- W4308968501 cites W2968154944 @default.
- W4308968501 cites W3005406872 @default.
- W4308968501 cites W3019749253 @default.
- W4308968501 cites W3096584975 @default.
- W4308968501 cites W3109876890 @default.
- W4308968501 cites W4212961135 @default.
- W4308968501 cites W4297216164 @default.
- W4308968501 cites W4313344708 @default.
- W4308968501 doi "https://doi.org/10.1128/iai.00328-22" @default.
- W4308968501 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36374101" @default.
- W4308968501 hasPublicationYear "2022" @default.
- W4308968501 type Work @default.
- W4308968501 citedByCount "0" @default.
- W4308968501 crossrefType "journal-article" @default.
- W4308968501 hasAuthorship W4308968501A5003508150 @default.
- W4308968501 hasAuthorship W4308968501A5009792917 @default.
- W4308968501 hasAuthorship W4308968501A5027671539 @default.
- W4308968501 hasAuthorship W4308968501A5048455792 @default.
- W4308968501 hasAuthorship W4308968501A5048923360 @default.
- W4308968501 hasBestOaLocation W43089685012 @default.
- W4308968501 hasConcept C159047783 @default.
- W4308968501 hasConcept C159654299 @default.
- W4308968501 hasConcept C203014093 @default.
- W4308968501 hasConcept C2777038808 @default.
- W4308968501 hasConcept C2777391075 @default.
- W4308968501 hasConcept C2778651837 @default.
- W4308968501 hasConcept C2779341262 @default.
- W4308968501 hasConcept C2780122209 @default.
- W4308968501 hasConcept C3017875465 @default.
- W4308968501 hasConcept C51785407 @default.
- W4308968501 hasConcept C86803240 @default.
- W4308968501 hasConcept C8891405 @default.
- W4308968501 hasConcept C89423630 @default.
- W4308968501 hasConceptScore W4308968501C159047783 @default.
- W4308968501 hasConceptScore W4308968501C159654299 @default.
- W4308968501 hasConceptScore W4308968501C203014093 @default.
- W4308968501 hasConceptScore W4308968501C2777038808 @default.
- W4308968501 hasConceptScore W4308968501C2777391075 @default.
- W4308968501 hasConceptScore W4308968501C2778651837 @default.
- W4308968501 hasConceptScore W4308968501C2779341262 @default.
- W4308968501 hasConceptScore W4308968501C2780122209 @default.
- W4308968501 hasConceptScore W4308968501C3017875465 @default.
- W4308968501 hasConceptScore W4308968501C51785407 @default.
- W4308968501 hasConceptScore W4308968501C86803240 @default.
- W4308968501 hasConceptScore W4308968501C8891405 @default.
- W4308968501 hasConceptScore W4308968501C89423630 @default.
- W4308968501 hasFunder F4320337354 @default.
- W4308968501 hasFunder F4320337355 @default.
- W4308968501 hasIssue "12" @default.
- W4308968501 hasLocation W43089685011 @default.
- W4308968501 hasLocation W43089685012 @default.
- W4308968501 hasLocation W43089685013 @default.
- W4308968501 hasLocation W43089685014 @default.
- W4308968501 hasOpenAccess W4308968501 @default.
- W4308968501 hasPrimaryLocation W43089685011 @default.
- W4308968501 hasRelatedWork W1605489596 @default.
- W4308968501 hasRelatedWork W1607889907 @default.
- W4308968501 hasRelatedWork W1677760721 @default.
- W4308968501 hasRelatedWork W1759851753 @default.
- W4308968501 hasRelatedWork W1816625861 @default.
- W4308968501 hasRelatedWork W1929514407 @default.