Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308977417> ?p ?o ?g. }
- W4308977417 endingPage "152136" @default.
- W4308977417 startingPage "152136" @default.
- W4308977417 abstract "A hallmark of disease pathogenesis of systemic sclerosis (SSc) is the presence of autoreactive B cell responses targeting nuclear proteins. Almost all SSc-patients harbour circulating antinuclear autoantibodies of which anti-topoisomerase 1, anti-centromere protein, anti-RNA polymerase III and anti-fibrillarin autoantibodies (ATA, ACA, ARA and AFA, respectively) are the most common and specific for SSc. In clinical practice, autoantibodies serve as diagnostic biomarkers and can aid in the identification of clinical phenotypes of the disease. However, factors driving disease progression in SSc are still poorly understood, and it is difficult to predict disease trajectories in individual patients. Moreover, treatment decisions remain rather empirical, with variable response rates in clinical trials due to patient heterogeneity. Current evidence has indicated that certain patients may benefit from B cell targeting therapies. Hence, it is important to understand the contribution of the antinuclear autoantibodies and their underlying B cell response to the disease pathogenesis of SSc." @default.
- W4308977417 created "2022-11-20" @default.
- W4308977417 creator A5006079113 @default.
- W4308977417 creator A5034627403 @default.
- W4308977417 creator A5042471556 @default.
- W4308977417 creator A5052842332 @default.
- W4308977417 creator A5058862111 @default.
- W4308977417 creator A5076410429 @default.
- W4308977417 creator A5085046817 @default.
- W4308977417 creator A5091791363 @default.
- W4308977417 date "2023-02-01" @default.
- W4308977417 modified "2023-10-14" @default.
- W4308977417 title "Autoreactive B cell responses targeting nuclear antigens in systemic sclerosis: Implications for disease pathogenesis" @default.
- W4308977417 cites W1520041405 @default.
- W4308977417 cites W1538849949 @default.
- W4308977417 cites W1548465609 @default.
- W4308977417 cites W1570354759 @default.
- W4308977417 cites W1593209859 @default.
- W4308977417 cites W1922560734 @default.
- W4308977417 cites W1952126894 @default.
- W4308977417 cites W1966506431 @default.
- W4308977417 cites W1971951944 @default.
- W4308977417 cites W1973662600 @default.
- W4308977417 cites W1975931941 @default.
- W4308977417 cites W1976007286 @default.
- W4308977417 cites W1978234008 @default.
- W4308977417 cites W1978280209 @default.
- W4308977417 cites W1979433399 @default.
- W4308977417 cites W1980174384 @default.
- W4308977417 cites W1980442679 @default.
- W4308977417 cites W1982754000 @default.
- W4308977417 cites W1987695869 @default.
- W4308977417 cites W1988241269 @default.
- W4308977417 cites W1989109175 @default.
- W4308977417 cites W1989678120 @default.
- W4308977417 cites W1996882626 @default.
- W4308977417 cites W2000969329 @default.
- W4308977417 cites W2007995761 @default.
- W4308977417 cites W2007995865 @default.
- W4308977417 cites W2008227366 @default.
- W4308977417 cites W2009065292 @default.
- W4308977417 cites W2011937484 @default.
- W4308977417 cites W2012653022 @default.
- W4308977417 cites W2020283889 @default.
- W4308977417 cites W2028085108 @default.
- W4308977417 cites W2028801154 @default.
- W4308977417 cites W2030372916 @default.
- W4308977417 cites W2034124263 @default.
- W4308977417 cites W2034255242 @default.
- W4308977417 cites W2035705144 @default.
- W4308977417 cites W2036226275 @default.
- W4308977417 cites W2037707055 @default.
- W4308977417 cites W2039764245 @default.
- W4308977417 cites W2042385706 @default.
- W4308977417 cites W2044767387 @default.
- W4308977417 cites W2045193092 @default.
- W4308977417 cites W2046958946 @default.
- W4308977417 cites W2048581410 @default.
- W4308977417 cites W2050702365 @default.
- W4308977417 cites W2054254671 @default.
- W4308977417 cites W2054740150 @default.
- W4308977417 cites W2055295263 @default.
- W4308977417 cites W2056293311 @default.
- W4308977417 cites W2058586537 @default.
- W4308977417 cites W2062462022 @default.
- W4308977417 cites W2071353934 @default.
- W4308977417 cites W2073898388 @default.
- W4308977417 cites W2076376776 @default.
- W4308977417 cites W2078578609 @default.
- W4308977417 cites W2078610240 @default.
- W4308977417 cites W2078984463 @default.
- W4308977417 cites W2084888025 @default.
- W4308977417 cites W2085898566 @default.
- W4308977417 cites W2087868660 @default.
- W4308977417 cites W2089255535 @default.
- W4308977417 cites W2090584556 @default.
- W4308977417 cites W2099892156 @default.
- W4308977417 cites W2103732215 @default.
- W4308977417 cites W2105316222 @default.
- W4308977417 cites W2105823977 @default.
- W4308977417 cites W2119933186 @default.
- W4308977417 cites W2120465956 @default.
- W4308977417 cites W2121599003 @default.
- W4308977417 cites W2122167649 @default.
- W4308977417 cites W2124445299 @default.
- W4308977417 cites W2129498411 @default.
- W4308977417 cites W2130052733 @default.
- W4308977417 cites W2131174779 @default.
- W4308977417 cites W2135165452 @default.
- W4308977417 cites W2138830547 @default.
- W4308977417 cites W2143000096 @default.
- W4308977417 cites W2143086765 @default.
- W4308977417 cites W2146597908 @default.
- W4308977417 cites W2150915632 @default.
- W4308977417 cites W2152917175 @default.
- W4308977417 cites W2153709755 @default.
- W4308977417 cites W2155113006 @default.
- W4308977417 cites W2155449287 @default.