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- W4308981507 abstract "A recent Nature study delineates a stepwise genomic evolution during pancreatic cancer development, employing an engineered mutant Kras and heterozygous Trp53 mouse model that identifies cells undergoing Trp53 loss of heterozygosity (LOH). Genetic progression post-Trp53 LOH involves clonal deletions, then genome doubling and subsequent accumulation of subclonal gains and amplifications." @default.
- W4308981507 created "2022-11-20" @default.
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- W4308981507 date "2022-11-01" @default.
- W4308981507 modified "2023-10-09" @default.
- W4308981507 title "Loss of p53 and genetic evolution in pancreatic cancer: Ordered chaos after the guardian is gone" @default.
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- W4308981507 doi "https://doi.org/10.1016/j.ccell.2022.10.020" @default.
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