Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308984953> ?p ?o ?g. }
- W4308984953 endingPage "1323" @default.
- W4308984953 startingPage "1309" @default.
- W4308984953 abstract "Introduction Cancer is highly adaptable and is constantly evolving against current targeted therapies such as tyrosine kinase inhibitors. Despite advances in recent decades, the emergence of drug resistance to tyrosine kinase inhibitors constantly hampers therapeutic efficacy of cancer treatment. Continuous therapy versus intermittent clinical regimen has been a debate in drug administration of cancer patients. An ecologically-inspired shift in cancer treatment known as ‘adaptive therapy’ intends to improve the drug administration of drugs to cancer patients that can delay emergence of drug resistance.Areas covered We discuss improved understanding of the concept of drug resistance, the basis of continuous therapy, intermittent clinical regimens, and adaptive therapy will be reviewed. In addition, we discuss how adaptive therapy provides guidance for future cancer treatment.Expert opinion The current understanding of drug resistance in cancer leads to poor prognosis and limited treatment options in patients. Fighting drug resistance mutants is constantly followed by new forms of resistance. In most reported cases, continuous therapy leads to drug resistance and an intermittent clinical regimen vaguely delays it. However, adaptive therapy, conceptually, exploits multiple parameters that can suppress the growth of drug resistance and provides safe treatment for cancer patients in the future." @default.
- W4308984953 created "2022-11-20" @default.
- W4308984953 creator A5008159834 @default.
- W4308984953 creator A5045924616 @default.
- W4308984953 creator A5057071005 @default.
- W4308984953 creator A5058876513 @default.
- W4308984953 creator A5088387922 @default.
- W4308984953 date "2022-11-24" @default.
- W4308984953 modified "2023-10-16" @default.
- W4308984953 title "Adaptive therapy to circumvent drug resistance to tyrosine kinase inhibitors in cancer: is it clinically relevant?" @default.
- W4308984953 cites W1969400354 @default.
- W4308984953 cites W1985264867 @default.
- W4308984953 cites W1990265701 @default.
- W4308984953 cites W1997133017 @default.
- W4308984953 cites W1999614615 @default.
- W4308984953 cites W2002903734 @default.
- W4308984953 cites W2004802243 @default.
- W4308984953 cites W2006960455 @default.
- W4308984953 cites W2011474502 @default.
- W4308984953 cites W2045806105 @default.
- W4308984953 cites W2047549748 @default.
- W4308984953 cites W2061581498 @default.
- W4308984953 cites W2067414313 @default.
- W4308984953 cites W2076449567 @default.
- W4308984953 cites W2079517811 @default.
- W4308984953 cites W2081213990 @default.
- W4308984953 cites W2081437435 @default.
- W4308984953 cites W2081911594 @default.
- W4308984953 cites W2093613683 @default.
- W4308984953 cites W2096258216 @default.
- W4308984953 cites W2098662106 @default.
- W4308984953 cites W2101476607 @default.
- W4308984953 cites W2102086339 @default.
- W4308984953 cites W2105317859 @default.
- W4308984953 cites W2111328291 @default.
- W4308984953 cites W2112833912 @default.
- W4308984953 cites W2114383061 @default.
- W4308984953 cites W2117768564 @default.
- W4308984953 cites W2125172197 @default.
- W4308984953 cites W2136263263 @default.
- W4308984953 cites W2140932756 @default.
- W4308984953 cites W2142578477 @default.
- W4308984953 cites W2143108036 @default.
- W4308984953 cites W2145980885 @default.
- W4308984953 cites W2154130790 @default.
- W4308984953 cites W2159141783 @default.
- W4308984953 cites W2160766792 @default.
- W4308984953 cites W2161066249 @default.
- W4308984953 cites W2161117534 @default.
- W4308984953 cites W2272802268 @default.
- W4308984953 cites W2277895489 @default.
- W4308984953 cites W2343874649 @default.
- W4308984953 cites W23858618 @default.
- W4308984953 cites W2400274474 @default.
- W4308984953 cites W2507849409 @default.
- W4308984953 cites W2529087403 @default.
- W4308984953 cites W2586629973 @default.
- W4308984953 cites W2592828140 @default.
- W4308984953 cites W2606935597 @default.
- W4308984953 cites W2625961828 @default.
- W4308984953 cites W2734942005 @default.
- W4308984953 cites W2735449222 @default.
- W4308984953 cites W2736656090 @default.
- W4308984953 cites W2743898608 @default.
- W4308984953 cites W2766675835 @default.
- W4308984953 cites W2767869290 @default.
- W4308984953 cites W2770572337 @default.
- W4308984953 cites W2772677509 @default.
- W4308984953 cites W2784078378 @default.
- W4308984953 cites W2801021134 @default.
- W4308984953 cites W2802173235 @default.
- W4308984953 cites W2899139598 @default.
- W4308984953 cites W2900776236 @default.
- W4308984953 cites W2901524277 @default.
- W4308984953 cites W2903677595 @default.
- W4308984953 cites W2909704566 @default.
- W4308984953 cites W2914878189 @default.
- W4308984953 cites W2919918774 @default.
- W4308984953 cites W2928679018 @default.
- W4308984953 cites W2945371661 @default.
- W4308984953 cites W2950793087 @default.
- W4308984953 cites W2951890973 @default.
- W4308984953 cites W2953475087 @default.
- W4308984953 cites W2979771750 @default.
- W4308984953 cites W2981929106 @default.
- W4308984953 cites W2993751725 @default.
- W4308984953 cites W2994525287 @default.
- W4308984953 cites W2998744531 @default.
- W4308984953 cites W3003174901 @default.
- W4308984953 cites W3004060585 @default.
- W4308984953 cites W3004640658 @default.
- W4308984953 cites W3005675684 @default.
- W4308984953 cites W3027762032 @default.
- W4308984953 cites W3034005842 @default.
- W4308984953 cites W3034482012 @default.
- W4308984953 cites W3036304621 @default.
- W4308984953 cites W3042222489 @default.
- W4308984953 cites W3044006916 @default.