FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308985061> ?p ?o ?g. }

• W4308985061 abstract "Abstract Background Vitamin D has been found to be protective against biological processes associated with Alzheimer’s disease and cognition, including amyloid-β deposition, but the evidence in relation to cognitive decline is scarce. Objective This study aims to investigate the relationship between 25(OH)D serum levels and changes in cognitive performance over time in middle-aged and older English adults. Research Design and Methods An observational study design. We analyzed data collected biannually over a 6-year follow-up from a prospective cohort, the English Longitudinal Study of Ageing (ELSA). Mixed Linear Models analyses were conducted. The analytical sample consisted of 5,365 participants aged 50 and older without a diagnosis of dementia at baseline. Cognitive performance was ascertained with memory and orientation. Both tests were administered at every ELSA wave from Wave 6 (2012-2013) to Wave 9 (2018-2019). The values of blood levels of 25(OH)D and all covariates were considered at Wave 6 since this was the first time 25(OH)D was assessed. Blood levels of 25(OH)D were dichotomized in high versus low using the common threshold of 31nmol/l. Results A significant positive association was found between low serum levels of 25(OH)D and baseline memory scores (β= -0.28, SE=0.05, p≤0.001), but not with changes in memory over time. Furthermore, baseline blood levels of 25(OH)D were not associated with baseline orientation or changes in orientation over time. Discussion In this representative sample of the English population, we found that lower 25(OH)D serum levels were associated with a lower baseline memory but did not influence the change in cognitive functioning over time. Implications This study provides further clarification in understanding the deficient role of 25(OH)D on cognitive performance and the change in cognitive functioning over time." @default.
• W4308985061 created "2022-11-20" @default.
• W4308985061 creator A5020480537 @default.
• W4308985061 creator A5066408493 @default.
• W4308985061 creator A5077985793 @default.
• W4308985061 date "2022-11-14" @default.
• W4308985061 modified "2023-10-16" @default.
• W4308985061 title "Vitamin D and changes in cognitive performance in mid and later life: findings from the English Longitudinal Study of Ageing (ELSA)" @default.
• W4308985061 cites W1967546229 @default.
• W4308985061 cites W1977007818 @default.
• W4308985061 cites W1982863387 @default.
• W4308985061 cites W2013570006 @default.
• W4308985061 cites W2029724839 @default.
• W4308985061 cites W2098288813 @default.
• W4308985061 cites W2106647095 @default.
• W4308985061 cites W2111645738 @default.
• W4308985061 cites W2112778345 @default.
• W4308985061 cites W2121732549 @default.
• W4308985061 cites W2135816456 @default.
• W4308985061 cites W2140693230 @default.
• W4308985061 cites W2144217189 @default.
• W4308985061 cites W2159841137 @default.
• W4308985061 cites W2242899253 @default.
• W4308985061 cites W2320982663 @default.
• W4308985061 cites W2346637990 @default.
• W4308985061 cites W2578699935 @default.
• W4308985061 cites W2619115331 @default.
• W4308985061 cites W2740780484 @default.
• W4308985061 cites W2999622127 @default.
• W4308985061 cites W3022745318 @default.
• W4308985061 doi "https://doi.org/10.1101/2022.11.14.22282290" @default.
• W4308985061 hasPublicationYear "2022" @default.
• W4308985061 type Work @default.
• W4308985061 citedByCount "0" @default.
• W4308985061 crossrefType "posted-content" @default.
• W4308985061 hasAuthorship W4308985061A5020480537 @default.
• W4308985061 hasAuthorship W4308985061A5066408493 @default.
• W4308985061 hasAuthorship W4308985061A5077985793 @default.
• W4308985061 hasBestOaLocation W43089850611 @default.
• W4308985061 hasConcept C118552586 @default.
• W4308985061 hasConcept C124490489 @default.
• W4308985061 hasConcept C126322002 @default.
• W4308985061 hasConcept C142724271 @default.
• W4308985061 hasConcept C15744967 @default.
• W4308985061 hasConcept C169900460 @default.
• W4308985061 hasConcept C185711340 @default.
• W4308985061 hasConcept C201903717 @default.
• W4308985061 hasConcept C2777895361 @default.
• W4308985061 hasConcept C2779134260 @default.
• W4308985061 hasConcept C2779483572 @default.
• W4308985061 hasConcept C2908647359 @default.
• W4308985061 hasConcept C2984863031 @default.
• W4308985061 hasConcept C500499127 @default.
• W4308985061 hasConcept C71924100 @default.
• W4308985061 hasConcept C72563966 @default.
• W4308985061 hasConcept C74909509 @default.
• W4308985061 hasConcept C99454951 @default.
• W4308985061 hasConceptScore W4308985061C118552586 @default.
• W4308985061 hasConceptScore W4308985061C124490489 @default.
• W4308985061 hasConceptScore W4308985061C126322002 @default.
• W4308985061 hasConceptScore W4308985061C142724271 @default.
• W4308985061 hasConceptScore W4308985061C15744967 @default.
• W4308985061 hasConceptScore W4308985061C169900460 @default.
• W4308985061 hasConceptScore W4308985061C185711340 @default.
• W4308985061 hasConceptScore W4308985061C201903717 @default.
• W4308985061 hasConceptScore W4308985061C2777895361 @default.
• W4308985061 hasConceptScore W4308985061C2779134260 @default.
• W4308985061 hasConceptScore W4308985061C2779483572 @default.
• W4308985061 hasConceptScore W4308985061C2908647359 @default.
• W4308985061 hasConceptScore W4308985061C2984863031 @default.
• W4308985061 hasConceptScore W4308985061C500499127 @default.
• W4308985061 hasConceptScore W4308985061C71924100 @default.
• W4308985061 hasConceptScore W4308985061C72563966 @default.
• W4308985061 hasConceptScore W4308985061C74909509 @default.
• W4308985061 hasConceptScore W4308985061C99454951 @default.
• W4308985061 hasLocation W43089850611 @default.
• W4308985061 hasOpenAccess W4308985061 @default.
• W4308985061 hasPrimaryLocation W43089850611 @default.
• W4308985061 hasRelatedWork W182016951 @default.
• W4308985061 hasRelatedWork W1972556217 @default.
• W4308985061 hasRelatedWork W2070165017 @default.
• W4308985061 hasRelatedWork W2097375910 @default.
• W4308985061 hasRelatedWork W245878504 @default.
• W4308985061 hasRelatedWork W2596715456 @default.
• W4308985061 hasRelatedWork W2766474056 @default.
• W4308985061 hasRelatedWork W2951679589 @default.
• W4308985061 hasRelatedWork W4286275029 @default.
• W4308985061 hasRelatedWork W4293102864 @default.
• W4308985061 isParatext "false" @default.
• W4308985061 isRetracted "false" @default.
• W4308985061 workType "article" @default.