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• W4308985503 endingPage "160164" @default.
• W4308985503 startingPage "160164" @default.
• W4308985503 abstract "Cadmium (Cd) is a typical pollutant in marine environment. Increasing studies have focused on the toxicological effects of Cd in marine bivalves. However, there were many conflicting findings of toxicological effects of Cd in marine bivalves. An integrated analysis performed on the published data of Cd toxicity in marine bivalves is still absent. In this study, a meta-analysis was performed on the toxic endpoints in bivalves exposed to aqueous-phase Cd from 87 studies screened from 1519 papers. Subgroup analyses were conducted according to the categories of species, tissue, exposure dose and duration. The results showed significant species-, duration- and dose-dependent responses in bivalves to aqueous-phase Cd exposure. In details, clams were more sensitive to Cd than oysters, mussels and scallops, indicated by the largest effect size in clams. Gill, hepatopancreas and hemolymph were top three tissues used to indicate Cd-induced toxicity and did not present a significant tissue-specific manner among them. With regard to toxicological effect subgroups, oxidative stress and detoxification were top two subgroups indicating Cd toxicities. Detoxification and genotoxicity subgroups presented higher response magnitudes. What is more, toxicological effect subgroups presented multiple dose- and duration-dependent curves. Oxidative stress and genotoxicity related endpoints presented significant increase trends with Cd exposure dose and were preferable biomarkers to marine Cd pollution. Detoxification and energy metabolism related endpoints showed inverted U-shaped and U-shaped dose-response curves, both of which could be explained by hormesis. The linear decrease in oxidative stress and energy metabolism related endpoints over time suggested their involvement into the adaptive mechanism in bivalves. Overall, this study provided not only a better understanding the responsive mechanisms of marine bivalves to Cd stress, but also a selection reference for biomarkers to aqueous-phase Cd pollution in marine environment." @default.
• W4308985503 created "2022-11-20" @default.
• W4308985503 creator A5017479066 @default.
• W4308985503 creator A5023776933 @default.
• W4308985503 creator A5025178044 @default.
• W4308985503 creator A5040576935 @default.
• W4308985503 creator A5058265257 @default.
• W4308985503 date "2023-02-01" @default.
• W4308985503 modified "2023-10-14" @default.
• W4308985503 title "Meta-analysis reveals the species-, dose- and duration-dependent effects of cadmium toxicities in marine bivalves" @default.
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